Prostate-specific antigen (PSA) was discovered in the 1970s, with assays to detect PSA in blood approved by the US Food and Drug Administration in 1986. Almost from the very beginning, its role as a prostate cancer marker has been severely misunderstood. One of the most well-known misconceptions is that prostate cancer detectable by elevated PSA in asymptomatic men requires treatment, irrespective

It is widely interpreted that there is a significant link between climate cooling at the Eocene-Oligocene Transition(EOT; ~34 Ma) and subsequent diatom proliferation in the world’s oceans during the mid to late Cenozoic. Yet,our understanding of biogenic silica flux through the EOT interval is based on limited data from a few sites, andthere are many complications in making a meaningful comparison

This paper describes the development of a fixed dose dry powder combination of indacaterol maleate (Inda) and glycopyrronium bromide (Glyco) in Easyhaler® inhaler for a comparative pharmacokinetic (PK) study, as well as the outcome of such a study. The development aim was to produce formulations with three different in vitro dispersibility profiles for both Inda and Glyco. This so-called ‘rake’ ap

Objectives Distribution of take-home naloxone is suggested to reduce opioid-related fatalities, but few studies have examined the effects on overdose deaths in the general population of an entire community. This study aimed to assess the effects on overdose deaths of a large-scale take-home naloxone programme starting in June 2018, using an observational design with a historic control period. Desi

Background: Shared reading (SR) is a group reading concept consisting of weekly meetings led by a trained facilitator where literary fiction and poetry is read aloud and discussed. SR requires no previous knowledge or homework and has been tried out as a health intervention to different vulnerable populations.

This article situates Henrik Vigh’s concept of “chronic crisis” in social disaster research and humanitarian studies in order to explore how child survivors experience and address the prolonged consequences of disasters. The rationale for mobilising the concept of chronic crisis is that it opens up possibilities for exploring dynamics and multidimensionality of disasters and humanitarian responses

Since the early 1990s, many variants of the tPSA assay have been introduced to increase the sensitivity of screening programs (cancer detection) while maintaining specificity (elimination of unnecessary biopsies). Again, these guidelines recommend ways that individuals and their physicians can use these new techniques rationally for early detection of prostate cancer. These guidelines are not desi

Background: Several studies have shown associations between cadmium (Cd) exposure and an increased risk of fractures. However, the size of the risk is still unclear and proper adjustment for smoking is a challenge. The aim of this study was to quantify the association between dietary cadmium measured in blood and fracture risk in the general Swedish population through a large population-based case

Globally, Sweden is often perceived as a relatively equal society. Swedish citizens pay significant amount of taxes and taxation on income is progressive. In addition, it is an explicit task of Swedish social services nationwide to counteract inequality and serve as a “last resort” for the country’s most vulnerable people. Social services are publicly funded, and support from the social services aGlobally, Sweden is often perceived as a relatively equal society. Swedish citizens pay significant amount of taxes and taxation on income is progressive. In addition, it is an explicit task of Swedish social services nationwide to counteract inequality and serve as a “last resort” for the country’s most vulnerable people. Social services are publicly funded, and support from the social services a

Listening is often ignored and not understood as an organizational strategic resource. In this conceptual article, we explain why listening is downplayed by combining the two research fields Service Management and Strategic Communication. We propose that organizations embrace service logic as a perspective of managing organizations. Service logic has a stakeholder-centric approach to value creatio

Accessing embedded test and monitoring circuitry (the so-called embedded instruments) in in-field products can reduce maintenance and diagnostics costs. Performing such access can be facilitated when done over an internal system bus, due to that it might be faster and less cumbersome to reach a system processor (on an in-field product) over a network interface, compared with the effort and speed o

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is caused by the degeneration and loss of dopamine (DA) neurons in the ventral midbrain (VM). The focal and progressive degeneration of DA neurons in the VM makes PD a particularly attractive target for cell-based therapies. Human pluripotent stem cells (hPSCs) offer unprecedented opportunities to model the

Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiova

Collaboration has the potential to strengthen both professional learning and well-being for teachers. However, it can also bring problematic aspects, such as increased workload and conflicts. The purpose of this study was to explore biology teachers’ experiences of collaboration to better understand how upper secondary school organisations can support teachers to obtain valuable collaborations. By

Background: Lumbar puncture (LP) is a common invasive procedure, most frequently performed to diagnose infection. Physicians perform LP in newborn infants with the help of an assistant using a strict aseptic technique; it is important to monitor the infant during all the steps of the procedure. Without adequate analgesia, LP can cause considerable pain and discomfort. As newborns have increased se

BACKGROUND: The benefit:risk profile of bivalirudin versus heparin anticoagulation in patients with non-ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) is uncertain. Study-level meta-analyses lack granularity to provide conclusive answers. We sought to compare the outcomes of bivalirudin and heparin in patients with non-ST-segment-elevation myocardial