Agonist-induced activation of smooth muscle involves a rise in intracellular Ca(2+) concentration and sensitization of myosin light chain phosphorylation to Ca(2+). Sr(2+) can enter through Ca(2+) channels, be sequestered and released from sarcoplasmic reticulum, and replace Ca(2+) in activation of myosin light chain phosphorylation. Sr(2+) cannot replace Ca(2+) in facilitation of agonist-activate

The mechanical effects of the intermediate filament protein desmin was examined in desmin deficient mice (Des-/-) and their wild type control (Des+/+). Active force generation was determined in intact soleus muscles and in skinned single fibres from soleus and psoas. A decreased force generation of skinned muscle fibres from Des-/- mice and a tendency towards decreased active force in intact soleu

Popular Abstract in Swedish Denna rapport handlar om hur framväxten av strategiskt betydelsefull kompetens kan föstås. Studien har tre teoretiska utgångspunkter hämtade ur resursbaserad strategiteori, strategisk human resource management samt organisatorisk inlärning. Genom en empirisk fallstudie av det snabbväxande högteknologiföretaget Axis Communications utvecklas en analyrsram genom vilken fraThe purpose of this thesis is to introduce the concept of distinctive competence in a multi-theoretical setting, consisting of the resource-based view, strategic human resource management and organizational learning, in order to develop a theoretical framework for better understanding of the dynamic side of distinctive competence. The empirical part of the study consists of an in-depth case study

Objective: An inability of the nervous system to fully activate the muscle is one factor that can contribute to age-related muscle weakness. Superimposed electrical stimulation can be used to determine voluntary muscle activation (VA). The aim of this study was to assess VA of the quadriceps muscle in healthy older and younger subjects. Design: Electrical stimulation causes moderate discomfort in

Background The design of the Exeter stem may facilitate distal migration, but radiostereometric analysis (RSA) studies have been limited to 2 years of follow-up. Patients and methods We followed migration of the Exeter femoral stems in 22 primary hip arthroplasties for 5 years with RSA. Results All stems migrated distally and the median migration at 2 years was 1.34 mm, while at 5 years it was 1

In this study the field effects on electrochemic ally controlled silicon etching in KOH during three- and four-electrode pn etch-stop have been investigated. When a p-doped bulk area is surrounded by n-doped silicon and the n-doped silicon is electrochemic ally passivated, small lines of bulk silicon in between the n-doped silicon would not etch. The size of the bulk silicon that did not etch coul

Popular Abstract in Swedish De nu gällande trafikpolitiska principerna för kostnadsansvaret lades fast i 1988 års trafikpolitiska beslut (Regeringens proposition 1987/88:50 om trafikpolitiken inför 1990-talet). Utgångspunkten för kostnadsansvaret är trafikavgifter på samhällsekonomiska villkor med syfte att ge rätt beteendesignaler på transportområdet. Från denna utgångspunkt har kostnadsansvaret Transport is a key factor for economic growth. It has enabled both the economic scale of production and an increase in competition. No one can question this role of transportation. There is, however, a back-side to the coin: the environmental challenge. Present trends show that transportation is not compatible with sustainable development. The need to internalise the external effects from trans-po

Background and Objective: The potential of using various multivariate analysis methods for classification of fluorescence spectra acquired in vivo from laryngeal tissues in Patients was investigated. Study Design/Materials and Methods: Autofluorescence spectra were measured on 29 normal tissue sites and 25 laryngeal lesions using 337-nm excitation. Four different multivariate analysis schemes were

This article is devoted to investigation of connection of operator representations of commutation relations XX*=F(X*X) and AB = BF(A) to periodic points and orbits of the dynamical system generated by the function F. Conditions on the general function F for two monomials in operators A and B to commute are derived. These conditions are further studied for dynamical systems generated by affine and

We have used DNase I footprinting and fluorescence melting studies to study the interaction of the hairpin polyamide Im-Py-Py-Py-(R)(H2N)gamma-Im`-PY-PY-PY-beta-Dp with its preferred binding sites (5'-WGWWCW; W=A or T) and other sequences. DNase I footprinting confirmed that the ligand binds to the sequence AGAACA at nanomolar concentrations and that changing the terminal A to G causes a dramatic

Breast cancer is a truly heterogenous disease, reflected in the existence of a wide spectrum of phenotypic subsets of tumours with varying intrinsic aggressiveness as well as ability to respond to a given treatment. Recent advances in large-scale genomic and proteomic screening techniques have confirmed this heterogeneity also at a molecular level, but there is still a bottleneck to be overcome be

Popular Abstract in Swedish Komplementsystemet är en del av immunförsvaret. Virus har utarbetat sätt för att skydda sig från komplementsystemet. Det humana herpesviruset KSHV (Kaposi's sarcoma-associated herpesvirus) har i sitt genom en gen som kodar för ett protein som vi har döpt till KCP (KSHV complement control protein). KCP har en transmembran del och en extracellulär del med fyra proteindomäViruses have developed several strategies to evade the complement system, a part of the immune system. The fourth open reading frame of the human virus Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a type 1 transmembrane protein. This contains four complement control protein domains (CCP domains), and is thus structurally similar to human complement inhibitors. We named it KSHV complement

The uptake of nutrients from deep soil layers has been shown to be important for the long-term nutrient sustainability of forest soils. When modelling nutrient uptake in forest ecosystems, the nutrient uptake capacity of trees is usually defined by the root distribution. However, this leads to the assumption that roots at different soil depths have the same capacity to take up nutrients. To invest

The effect of UV radiation (half-band width 10 nm) in the wavelength range 248-340 nm on chlorophyll fluorescence from a thin layer of spinach thylakoid suspension was investigated. The parameter most sensitive to UV radiation was the rise time of variable fluorescence. The increase in rise time was proportional to UV photon fluence and was used for the determination of an action spectrum. The act