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Gene editing of CD34+ progenitor cells from single blood donor waste bags to create cultured early erythroid cells for study of blood group knock-outs

Background: Many blood group antigens are carried by red cell surface proteins, thefunctions of which are not yet fully characterized or in some cases completelyunknown. By investigating red cells with naturally-occurring blood group variants,much has been learnt about the underlying molecules. However, interindividualvariation affecting other molecules than the one(s) of interest may confound oro

The unresolved phylogenomic tree of butterflies and moths (Lepidoptera) : Assessing the potential causes and consequences

The field of molecular phylogenetics is being revolutionized with next-generation sequencing technologies making it possible to sequence large numbers of genomes for non-model organisms ushering us into the era of phylogenomics. The current challenge is no longer how to get enough data, but rather how to analyse the data and how to assess the support for the inferred phylogeny. Here, we focus on o

International cooperation for decarbonizing energy intensive industries: the case for a Green Materials Club

Basic materials are traded globally and responsible for roughly 22 % of global carbon emissions. It is technically possible for the energy intensive industries (EIIs) that produce these materials to reach zero emission, but at a cost. So far, the fear of carbon leakage has been a barrier for implementing ambitious domestic climate policies that targets theses globally traded commodities. The intro

Pange lingua : en klassisk hymn till det frälsande korset

Pange lingua är en hymn från femhundratalet av Venantius Fortunatus. Den sjöngs under fastetiden och framför allt på långfredagen och återfinns i Den svenska psalmboken, men inte som en regelrätt översättning utan som bearbetningar och förkortningar, i psalmerna 147 och 456. Artikeln ger en bakgrund till hymnens tillkomst och en nyöversättning av hela hymnen.

Återställning av förorenade områden efter en RN-olycka : Samhällets problem och hur bästa kombination av långsiktiga åtgärder kan väljas för att skydda människor i bebyggda miljöer mot bestrålning

Detta projekt har syftat till att ge svenska myndigheter och beslutsfattare enbeskrivning av samhällets problem efter ett kraftigt nedfall av långlivade radioaktivaämnen och hur den bästa kombinationen av åtgärder kan väljas för att skyddamänniskor mot bestrålning med hänsyn till ekonomiska, sociala och samhälleligafaktorer. Arbetet med att återställning av ett tätortsområde som berörts av enomfat

Illness Experience in Nephrotic Syndrome.

Background: Most patients with kidney disease have different degrees of proteinuria. Heavy proteinuria causes nephrotic syndrome. The incidences of nephrotic syndrome in adults are approximately three per 100 000 persons. Although if nephrotic syndrome is rare, it is a serious clinical condition. Little is known about health and wellbeing among patients with nephrotic syndrome. It is important for

Gas in Scattering Media Absorption Spectroscopy on Small and Large Scales: Towards the Extension of Lung Spectroscopic Monitoring to Adults

Numerous natural materials are porous, contain free gas, and are scattering light strongly. Scattering brings about a strong trapping of light and an associated prolonged transit time for photons through a medium. In contrast to the matrix materials, gas enclosures require very narrow‐band laser radiation for probing. We have in the present study used the gas in scattering media absorption spectro

Reconnection: Meeting the Climate Crisis Inside Out

Climate change is a physical reality, demanding political and practical solutions. But its inner dimension, overlooked entirely by mainstream approaches, is a human crisis of relationship. This report outlines the relevance of mindfulness and compassion practices in addressing the endemic disconnection from self, others and nature at the root of the climate crisis.We explore the cognitive and emot

Kulturarv till salu

Under våren 2022 ska den så kallade Everlöv-skatten säljas på offentlig auktion. Därför kommer skatten att splittras upp och föremålen därmed spridas vind för våg. Detta är mycket beklagansvärt ur vetenskaplig synvinkel, men även ur samhällets och allmänhetens perspektiv. Fornminnen och fornsaker, däribland naturligtvis vikingatida skattfynd, är vårt gemensamma kulturarv. Depåfyndet består av en s

Disparities in prevalence of heart failure according to age, multimorbidity level and socioeconomic status in southern Sweden : a cross-sectional study

OBJECTIVE: The aim of this study was to compare the prevalence of heart failure (HF) in relation to age, multimorbidity and socioeconomic status of primary healthcare centres in southern Sweden.DESIGN: A cross-sectional study.SETTING: The data were collected concerning diagnoses at each consultation in all primary healthcare centres and secondary healthcare in the southernmost county of Sweden at

Nuclear shape evolution based on microscopic level densities

By combining microscopically calculated level densities with the Metropolis walk method, we develop a consistent framework for treating the energy and angular-momentum dependence of the nuclear shape evolution in the fission process. For each nucleus under consideration, the level density is calculated microscopically for each of more than five million shapes with a recently developed combinatoria

Fast-neutron-induced fission cross section of Pu 242 measured at the neutron time-of-flight facility nELBE

The fast-neutron-induced fission cross section of Pu242 was measured at the neutron time-of-flight facility nELBE. A parallel-plate fission ionization chamber with novel, homogeneous, large-area Pu242 deposits on Si-wafer backings was used to determine this quantity relative to the IAEA neutron cross-section standard U235(n,f) in the energy range of 0.5 to 10 MeV. The number of target nuclei was d

Interaction effect of sex and onset of Alzheimer’s disease—rates of progression and prognosis.

Objectives: To investigate the interaction effect of sex and early vs. late onset of Alzheimer’s disease (AD) on long-term cognitive and functional outcomes and survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study of clinical practice involving 1,017 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibito