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OBJECTIVE: Parathyroid adenomas frequently harbour deletions of genomic DNA at chromosome regions 1p, 6q and 11q. In this study we related clinical characteristics in 56 patients with primary hyperparathyroidism (pHPT) to loss of heterozygosity (LOH) in these chromosome regions.DESIGN: LOH analysis was performed on 56 sporadic parathyroid tumours using a total of 18 microsatellite markers for chro
Sepsis is associated with exaggerated neutrophil responses although mechanisms remain elusive. The aim of this study was to investigate the role of c-Abelson (c-Abl) kinase in neutrophil extracellular trap (NET) formation and inflammation in septic lung injury. Abdominal sepsis was induced by cecal ligation and puncture (CLP). NETs were detected by electron microscopy in the lung and by confocal m
Objective: A few studies have suggested that patients with inflammatory arthritis (IA) who remain persistent with subcutaneous TNF-α inhibitors (SC-TNFi) incur lower health care costs than patients who discontinue treatment, whereas data on the impact of non-persistence on indirect costs are largely lacking. Furthermore, existing estimates are based on fixed follow-ups, in relation to treatment in
Background: Despite intense research, the prognosis for patients with advanced colorectal cancer (CRC) remains poor. The prostaglandin D2 receptors DP1 and DP2 are explored here as potential therapeutic targets for advanced CRC. Methods: A CRC cohort was analysed to determine whether DP1 and DP2 receptor expression correlates with patient survival. Four colon cancer cell lines and a zebrafish meta
Denna reflektion handlar om hur videoessän, som ett alternativ till mer traditionella examinationsformer, kan bidra till att utveckla studenters medie- och informationskunnighet. Videoessäns funktion i film- och medievetenskaplig utbildning presenteras. Därefter diskuteras det pedagogiska upplägget för kursen där videoessän ingick som examinationsmoment. En slutsats är att videoessän är en examina
Coronapandemin i kombination med ökad e-handel har varit ännu ett svårt slag mot svenska stadskärnor. Under 2020 och 2021 har flera stora butikskedjor valt att lämna stadskärnorna till förmån för externa handelsplatser och onlinehandel. Larmrapporterna och lösningar på problemet har varit många under 2021. Denna rapport är en analys och utvärdering av vad som sagts i media, tidigare forskning och
På Hovrätten över Skåne och Blekinge finns flera möbler och föremål som funnits och använts sedan 1800-talet. Vi lät docenterna Martin Sunnqvist och Linda Fagerström ta en titt på några saker som de tycker är intressanta att berätta mer om.Filmen är en del av hovrättens 200-årsjubileum som firas från maj 2021 till maj 2022. Mer information finns på hovrättens webbplats: www.domstol.se/jubileumsare
Background: The built environment needs to be designed so that all people can participate in the activities they want and need to do. Yet, accessibility is difficult to put into practice, and accessibility issues tend to be overlooked in the building and planning processes. Objectives: The aim of this scoping review was to summarize the research front in the area of accessibility to public buildin
There can be no doubt that discrimination based on sex, race, ethnicity, religion or beliefs should not be tolerated in academia. Surprisingly, however, in recent years, policies of Diversity, Inclusion and Equity (DIE), officially introduced to counteract discrimination, have increasingly led to quite the opposite result: the exclusion of individuals who do not share a radical ‘woke’ ideology on
Introduction: Fetal growth restriction is a major risk factor for adverse perinatal outcome. As most of the growth-restricted fetuses are small for gestational age (SGA), an efficient antenatal screening method for SGA fetuses would have a major impact on perinatal health. The aim of this study was to compare the SGA prediction rate achieved with third-trimester routine ultrasound estimation of fe
This paper presents a framework for integrating fire evacuation models into Building Information Modelling (BIM). The framework is intended to enhance coordination between stakeholders from diverse disciplines involved in the domain of fire evacuation design. It supports a full in/out data loop linking BIM and evacuation design tools, which enables professionals and authorities to review building
Recent years have witnessed great interest in mass-participation running events (Hindley, 2020), and organisations such as parkrun and fitness programmes like Couch to 5K, have been instrumental in enabling participation for inexperienced runners. Concomitant with this has been a number of fictional works which centre on the 5K run. I contend that exploring fictional texts can offer a fresh take o
Bertolt Brechts litterära och teoretiska texter från mellankrigstiden ter sig högst aktuella i vår egen tid. Nu som då framvisar den globala marknadsekonomin sina destruktiva sidor, samtidigt som totalitära ideologier tenderar att breda ut sig över världen. Åsiktsfrihet och grundläggande mänskliga rättigheter är under hård press även i länder där demokrati länge har betraktats som en självklarhet.
