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The cell cycle is a key regulator of endothelial cell specification into tip and stalk cell phenotypes, which are essential for angiogenesis in both normal development and pathological conditions. While the tumor suppressor p53 is known to regulate the cell cycle and influence cell fate, its role in modulating the cell fate of these phenotypes remains unclear. Using non-genotoxic small molecule an

Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported ouBackground: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported ou

Context. The chemical abundances of alpha elements in Galactic Centre (GC) supergiants provide key insights into the chemical enrichment and star formation history of the Milky Way’s nuclear star cluster. Previous studies have reported enhanced alpha-element abundances, which raises questions about the chemical evolution of this unique region. Aims. We aim to reassess the alpha-element abundances

Non-invasive methods for measuring thermal tolerance and thermoregulation in large numbers of individuals under natural environmental conditions are useful to understand the capacity of species to adapt to future climate scenarios. Infrared thermography (IRT) is one such tool in research on thermal adaptation, but concerns have been raised about its reliability, specifically the correlation betwee

This paper presents archeological data and chronometric dates documenting human presence in Serbia, central Balkans, during MIS 2. We describe findings from excavations at three cave sites and dating results from two additional localities. The evidence suggests that people were present in the area during the second half of the glacial peak between 25 and 19ka calBp. The chronological placement of

Background and aims: Gynoid fat (hip-thigh subcutaneous adiposity) is metabolically favorable, yet its genetic architecture and impact on liver diseases are unknown. We aimed to identify genetic determinants of gynoid tissue fat percentage (GTFP) and explore their clinical implications to liver disease. Methods: We conducted a genome-wide association study (GWAS) in 37,385 European individuals fro

BackgroundOsteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.AimTo investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.Methods999 community-dwelling women

Polyunsaturated fatty acids (PUFA) have been shown to reduce liver fat compared to saturated fat, but effects of a novel “anti-lipogenic” diet replacing carbohydrates with PUFA (LCPUFA) or a low-fat healthy Nordic diet (HND) rich in whole-grains are unknown. The objective of this study was to investigate the effects of these diets, as compared with usual care (UC), on liver fat (primary outcome) a

A package material blank comprises a body panel having a main panel, two second panels arranged adjacent to the main panel and at least one third panel. End closure panels arranged adjacent to the body panel, the end closure panels comprising a top and bottom closure panels arranged adjacent to the main and the at least one third panel, respectively and flap closure panels arranged adjacent to the

Digital cognitive assessments have rapidly expanded in Alzheimer's disease (AD) research, offering a sensitive, scalable, and cost-effective alternative to traditional neuropsychological tests. This systematic review examines the validation and utility of digital cognitive assessments in cognitively normal (CN) individuals and explores their potential classification within the US Food and Drug Adm

Background: The purpose of this study was to analyse if there is a relationship between the directions of windswept hip deformity and scoliosis for children with cerebral palsy (CP) and to explore potential associations with spasticity, contractures and hip displacement. Methods: A cross-sectional registry-based study was conducted using data from the combined Swedish CP Follow-up Program and Nati

Syftet med uppsatsen är att bedöma användningen av EncroChat bevisning inför svensk rätt utifrån den naturrättsliga filosofen Andrew Dworkins teori om statlig integritet. Enligt Dworkin är det viktigt att stater konsekvent till-lämpar moraliska och rättsliga principer i deras rättssystem, då detta ger sta-ten en intern integritet som stärker tilliten mellan den enskilde och det all-männa. UppsatseThe purpose of the paper is to assess the use of EncroChat evidence before Swedish law based on the natural law philosopher Andrew Dworkin’s theo-ry of state integrity. According to Dworkin, it is important that states con-sistently apply moral and legal in their legal systems, as this gives the states an internal integrity that strengthens trust between the individual and the public. The paper ex

Rates of hybridization are increasing globally, but we lack an understanding of both the history and evolutionary outcomes of hybridization for most species. This makes it difficult to understand whether, and to what extent, humans are influencing hybridization. Integrating field studies with whole genome data is a critical next step for understanding hybridization and the extent of human influenc

The so-called X17 particle has been proposed in order to explain a very significant resonant behaviour (in both the angular separation and invariant mass) of e+e− pairs produced during a nuclear transition of excited 8Be, 4He and 12C nuclei. Fits to the corresponding data point, as most probable explanation, to a spin-1 object, which is protophobic and has a mass of approximately 16.7 MeV, which t