Extracorporeal immunoadsorption (ECIA) is a new method for the selective removal of circulating radiolabeled monoclonal antibodies (MAb) from plasma to increase the uptake in tumor versus normal tissues (T/N-ratio). To ascertain whether the amount of MAb affects T/N ratios immediately and 24 h after ECIA, we used a rat model with two tumor sites--one intramuscular (im) and one below the subrenal c

Popular Abstract in Swedish I januari 1968 inträffade en flygplansolycka på havsisen ca 12 km väster om Thule flygbasen på nordvästra Grönland. Flygplanet, en amerikansk B-52, hade fyra kärnvapen ombord, som sprängdes sönder när planet störtade. Sprängningen orsakades av de konventionella sprängmedel som satt runt kärnladdningarna i de fyra vapnen. Dessa sprängningar var ej av nukleär art, d.v.s. This thesis concerns a nuclear accident that occurred in the Thule (Pituffik) area, NW Greenland in 1968, called the Thule accident. Results are based on different analytical techniques, i.e. gamma spectrometry, alpha spectrometry, ICP-MS, SEM with EDX and different sediment models, i.e. (CRS, CIC). The scope of the thesis is the study of hot particles. Studies on these have shown several interest

Popular Abstract in Swedish Den här avhandlingen handlar om hur kristaller, som innehåller en liten mängd av ämnen tillhörande gruppen sällsynta jordartsmetaller, kan användas för forskning och tillämpningar rörande kvantinformation. Genom att belysa kristallerna med laserljus kan atomernas tillstånd styras och studeras. I avhandlingen diskuteras olika aspekter av hur de sällsynta jordartsatomer sThis thesis describes investigations of the use of cryogenically cooled rare-earth-ion-doped crystals for quantum information processing and quantum optics. Several aspects of the coherent interaction between light and rare-earth ions in solids are addressed. Quantum information science has given physicists new views of quantum mechanics. The transmission of quantum states has already found pract

From a public database in Sweden we obtained a subject pool consisting of one group of 20 years old and another group exactly 50 years older. The groups participated in a mail-based trust game, in which the young cohort exhibited more trust than the older one. Subjects significantly preferred to place trust in co-players of their own cohort and of the female sex. When amounts sent and proportions

Background: Girls adopted from developing countries often have early or precocious puberty, requiring treatment with gonadotrophin-releasing hormone (GnRH) analogues. During such treatment, decreased growth velocity is frequent. Aim: To study whether the addition of growth hormone (GH) to GnRH analogue treatment improves final height in girls with early or precocious puberty. Methods: Forty-six gi

The aim of this work was to investigate sorting mechanisms of von Willebrand factor (VWF) when expressed in haematopoietic cells. The processing and sorting of both the wild-type VWF and a multimerization defective propeptide-mutant (VWFm) were investigated after expression in the 32D cell line. Normal proteolytic processing was observed for both proteins, however the processing of VWFm was much s

Popular Abstract in Swedish Celldöd är en lika viktig process som celldelning. Under hela ens liv måste vävnadens storlek regleras och gamla eller skadade celler förnyas. Detta styrs av en process som kallas programmerad cell död. Denna process är noggrant reglerad så att enbart oönskade celler tas bort. Om regleringen sätts ur funktion leder detta till ohämmad celldelning och cancer. Ett problem HAMLET (Human alpha-lactalbumin made lethal to tumor cells) is a molecular complex of alpha-lactalbumin and oleic acid, that induces programmed cells death in tumor cells but leaves healthy differentiated cells unaffected. It has a broad anti-tumor activity as more than 40 cell lines from different origin are sensitive. The cell death activity of HAMLET is retained in vivo. HAMLET limits the progr

A readily releasable pool (RRP) of granules has been proposed to underlie the first phase of insulin secretion. In the present study we combined electron microscopy, insulin secretion measurements and recordings of cell capacitance in an attempt to define this pool ultrastructurally. Mouse pancreatic B-cells contain approximately 9,000 granules, of which 7% are docked below the plasma membrane. Th

The functional role of aerobic lactate production in the rat portal vein was investigated. Changing substrate from glucose (11.5 mM) to pyruvate (11.5 mM) or beta-hydroxybutyrate (3 mM) had virtually no effect on spontaneous mechanical activity. Lactate production (FLA) was smaller with pyruvate than with glucose (0.05 +/- 0.01 vs. 0.14 +/- 0.03 mumol g-1 min-1, n = 4). Addition of 0.5 mM iodoacet

Popular Abstract in Swedish Detta är en avhandling om hur en del av vårt meningsskapande går till, sedd genom åtta studenters användning av sina kontextuella resurser. Den handlar om hur vi lyssnar till auditiva, visuella och upplevda röster, och hur vi talar med stöd av dessa röster när vi skapar och utvecklar vår egen röst. Detta kallar jag för rapporterat lyssnande, d.v.s. dessa yttranden visarThis thesis has two points of departure and four main purposes. The first point of departure concerns the narrow perspective of the listening skill in Swedish. The first purpose is to show the lack of attention to the listening skill in research and mother tongue education in the Swedish compulsory school. Educational documents from 1842 to 2000 about Swedish as a school subject are examined from

The near-field radiation pattern of a long thin slit (with a width much smaller than the excitation wavelength) in a uniform aluminum surface was measured and modeled by numerical computation. In particular, the interplay between the incident light polarization and the slit width is found to play an essential role in the near-field profile on the back side of the nanoslits. Two-dimensional finite-