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Nonstoichiometry in chlorellestadite

The structural development of apatite-type chlorellestadite was studied as a function of annealing time by Rietveld refinements based on X-ray powder diffraction data (Cu-K-alpha1). Annealing (900-1100 degreesC) in air of chlorellestadite with the unit cell content: Ca-9(SiO4)(3)(SO4)(3)-(1-x)CaC1(2) (x approximate to 0) produced a nonstoichiometric phase (0 less than or equal to x less than or eq

Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab

Objective. Infliximab, an anti-tumor necrosis factor alpha (anti-TNF alpha) antibody, is effective in the treatment of several immunoinflammatory diseases. However, many patients experience primary or secondary response failure, suggesting that individualization of treatment regimens may be beneficial. This study was undertaken to investigate whether serologic monitoring of infliximab bioavailabil

Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors

A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been

C-terminal flanking peptide of neuropeptide Y in DRG following nerve compression

The C-terminal flanking peptide of neuropeptide Y (CPON) was studied in dorsal root ganglia (DRG) by immunocytochemistry after different recovery periods (3, 6,14 and 28 days) following tourniquet compression of the rat hindlimb (sciatic nerve; 150 or 300 mmHg; 2 h). Compression induced a transient increase in the number of CPON-positive DRG-neurons (the contralateral uninjured side was devoid of

Case studies and mathematical models of ecological speciation 3: Ecotype formation in a Swedish snail

Formation of partially reproductively isolated ecotypes in the rough periwinkle, Littorina saxatilis, may be a case of incipient nonallopatric ecological speciation. To better understand the dynamics of ecotype formation, its timescale, driving forces and evolutionary consequences, we developed a spatially explicit, individual-based model incorporating relevant ecological, spatial and mate selecti

Geomagnetic field variations in northern Sweden during the Holocene quantified from varved lake sediments and their implications for cosmogenic nuclide production rates

Palaeomagnetic analyses were conducted on two varved lake-sediment sequences in northern Sweden. The magnetic properties of the sediment sequences are dominated by stable single-domain magnetite with characteristics typical of bacterial magnetosomes. Alternating field demagnetization measurements indicate that the single-domain magnetite is the dominant carrier of a stable natural remanent magneti

Antonymy and negation: the boundedness hypothesis

This paper investigates the interpretation of unbounded (scalar) adjective antonyms with and without negation such as (not) narrow – (not) wide and bounded adjective antonyms with and without negation such as (not) dead – (not) alive as well as their interpretations with approximating degree modifiers, fairly and almost, respectively. The investigation was designed to test the boundedness hypothes

A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation

Increased Se intakes have been associated with decreased risk of cancer and CVD. Several mechanisms have been proposed, including antioxidant effects through selenoproteins, induction of carcinogen metabolism and effects on the blood lipid profile. In a 4 x 1 week randomised, double-blind cross-over study, healthy young men supplemented their usual diet with selenate, Se-enriched yeast, Se-enriche

Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1

Despite oncogene amplification being a characteristic of many tumor types, the mechanisms leading to amplicon formation have remained largely unresolved. In this study, we used a combinatorial approach of fluorescence in situ hybridization and single-nucleotide polymorphism chip gene copy number analyses to unravel the mechanism leading to nonsyntenic coamplification of MYC and ATBF1 in SJNB-12 ce

Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation

Background Intraportal transplantation of pancreatic islets offers improved glycaemic control and insulin independence in type 1 diabetes mellitus, but intraportal thrombosis remains a possible complication. The thrombotic reaction may explain why graft loss occurs and islets from more than one donor are needed, since contact between human islets and ABO-compatible blood in vitro triggers a thromb

CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.

The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their a

Habitat fragmentation and the structure of genetic diversity within disjunct isolates of Anthericum ramosum L. (Anthericaceae) in Scandinavia

The lilioid herb, Anthericum ramosum, occurs in four geographically-isolated regions (Sjaelland, Skane, Oland and Gotland) in Denmark and southern Sweden. We investigated allozyme variation at nine polymorphic loci in A. ramosum from 16 sites (33 populations) in the four regions. There was no clear overall geographic pattern of differentiation between the regions, but the southernmost Gotland and

Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells

Recently, primitive human bone marrow (BM) progenitors supporting hematopoiesis in extended (>60 days) long-term BM cultures were identified. Such extended long-term culture-initiating cells (ELTC-IC) are of the CD34(+)CD38(-) phenotype, are quiescent, and are difficult to recruit into proliferation, implicating ELTC-IC as the most primitive human progenitor cells detectable in vitro. However, it