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Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Fish is a source of important nutrients and may play a role in preventing heart diseases and other health outcomes. However, studies of overall mortality and cause-specific mortality related to fish consumption are inconclusive. We examined the rate of overall mortality, as well as mortality from ischaemic heart disease and cancer in relation to the intake of total fish, lean fish, and fatty fish

Behavior of relative state selective photoionization cross sections of RbBr molecules in the valence region

The photon energy dependence of relative photoionization cross sections in the valence ionization energy region of 5 to 45 eV for 4p and 4s orbitals of Rb and Br ions in RbBr vapors has been investigated. The behavior of state selective cross sections of molecular valence orbitals has been analyzed by comparing the observed 4p to 4s photoelectron intensity branching ratios with atomic state select

Immunizations with unmodified tumor cells and simultaneous COX-2 inhibition eradicate malignant rat brain tumors and induce a long-lasting CD8(+) T cell memory.

Malignant brain tumors induce pronounced immunosuppression, which diminishes immune responses generated by immunotherapy. Here we report that peripheral immunotherapy, using irradiated unmodified whole tumor cells, and systemic cyclooxygenase-2 inhibition induce cure in glioma-bearing rats (60% cure rate), whereas neither monotherapy was sufficient to cure any animal. Moreover, the combined therap

Distributed Dynamic Reinforcement of Efficient Outcomes in Multiagent Coordination and Network Formation

We analyze reinforcement learning under so-called "dynamic reinforcement." In reinforcement learning, each agent repeatedly interacts with an unknown environment (i.e., other agents), receives a reward, and updates the probabilities of its next action based on its own previous actions and received rewards. Unlike standard reinforcement learning, dynamic reinforcement uses a combination of long-ter

Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors.

The differentiation stage of tumors is a central aspect in the histopathological classification of solid malignancies. The differentiation stage is strongly associated with tumor behavior, and generally an immature tumor is more aggressive than the more differentiated counterpart. While this is common knowledge in surgical pathology, the contribution of differentiation-related gene expression and

Cancer Cell Radiobiological Studies Using In-House-Developed α-Particle Irradiator.

An α-particle irradiator, enabling high-precision irradiation of cells for in vitro studies, has been constructed. The irradiation source was a (241)Am source, on which well inserts containing cancer cells growing in monolayer were placed. The total radioactivity, uniformity, and α-particle spectrum were determined by use of HPGe detector, Gafchromic™ dosimetry film, and PIPS(®) detector measureme

Mode 2 and the tension between excellence and utility: The case of a policy-relevant research field in Sweden

This paper investigates the impact of changing science policy doctrines on the development of an academic field, working life research. Working life research is an interdisciplinary field of study in which researchers and stakeholders collaborated to produce relevant knowledge. The development of the field, we argue, was both facilitated and justified by the, at the time dominant, science policy o

Growth of large area monolayer graphene on 3C-SiC and a comparison with other SiC polytypes

Epitaxial graphene growth was performed on the Si-terminated face of 4H-, 6H-, and 3C-SiC substrates by silicon sublimation from SiC in argon atmosphere at a temperature of 2000 degrees C. Graphene surface morphology, thickness and band structure have been assessed by using atomic force microscopy, low-energy electron microscopy, and angle-resolved photoemission spectroscopy, respectively. Differe

Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist.

Metabotropic glutamate receptor 4 (mGlu4) negatively modulates GABA and glutamate release in the 'indirect pathway' of the basal ganglia, and has thus been proposed as a potential target to treat motor symptoms in Parkinson's disease. Here, we present an extensive comparison of the behavioural effects produced by the mGlu4 positive allosteric modulator (PAM), VU0364770, and the mGlu4 orthosteric a

A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel.

The peptide GSFSIQYTYHV derived from human semenogelin I forms a transparent hydrogel through spontaneous self-assembly in water at neutral pH. Linear rheology measurements demonstrate that the gel shows a dominating elastic response over a large frequency interval. CD, fluorescence and FTIR spectroscopy and cryo-TEM studies imply long fibrillar aggregates of extended β-sheet. Dynamic light scatte

Process development of oxygen-demanding reactions utilizing a simple design with parallel glass tube reactors - Evaluated using Gluconobacter oxydans (DSM 24525)

To investigate the possibility of using simple glass tubes as reactors for oxygen-demanding reactions, a setup was assembled to study the initial rate of conversion of glycerol to dihydroxyacetone (DHA) using Gluconobacter oxydans. Several parallel 10 mL glass tubes were incubated in a temperature-controlled shaker. The concentration of DHA was determined using a fast spectrophotometric HPLC-based

Three new species of dinoflagellate cyst from Cretaceous-Paleogene (K-Pg) boundary sections at mid-Waipara River and Fairfield Quarry, South Island, New Zealand

A palynological investigation of marine uppermost Maastrichtian to lower Paleocene strata in two New Zealand sections, mid-Waipara River and Fairfield Quarry, revealed well-preserved dinoflagellate cyst assemblages including three new dinoflagellate cyst species. A formal description of the new dinoflagellate cyst species are presented here. Furthermore a variation of Carpatella cornuta, named C.

Validation of a protocol for manual segmentation of the thalamus on magnetic resonance imaging scans.

We present a validated protocol for manual segmentation of the thalamus on T1-weighted magnetic resonance imaging (MRI) scans using brain image analysis software. The MRI scans of five normal control subjects were randomly selected from a larger cohort recruited from Lund University Hospital and Landskrona Hospital, Sweden. MRIs were performed using a 3.0T Philips MR scanner, with an eight-channel

The macromolecular crystallography beamline I911-3 at the MAX IV laboratory.

The macromolecular crystallography beamline I911-3, part of the Cassiopeia/I911 suite of beamlines, is based on a superconducting wiggler at the MAX II ring of the MAX IV Laboratory in Lund, Sweden. The beamline is energy-tunable within a range between 6 and 18 keV. I911-3 opened for users in 2005. In 2010-2011 the experimental station was completely rebuilt and refurbished such that it has become

Simultaneous Control of Combustion Timing and Ignition Delay in Multi-Cylinder Partially Premixed Combustion

In low-temperature combustion concepts such as partially premixed combustion, the ignition delay should be large enough in order to ensure sufficient fuel and air mixing before the start of combustion. It is also necessary that the combustion timing is sufficiently well phased for high thermal efficiency. Since the ignition delay and combustion timing are intimately coupled, the decoupling of the

Communicating with individuals receiving home mechanical ventilation : the experiences of key communication partners

Purpose: The aim of the study was to explore the communication experiences of key communications partners (CPs) of individuals receiving home mechanical ventilation (HMV), with particular emphasis on the possibilities, difficulties and limitations CPs experienced in communication, possible support given to facilitate communication and exploring what made a skilled communicator. Method: A qualitati