Gestational Diabetes Mellitus in North India Gestational diabetes mellitus(GDM) defines an unhealthy state of hyperglycaemia that develops in response to an otherwise normal physiological adaptive insulin resistance state during pregnancy. However, the exact plasma glucose levels differentiating the unhealthy GDM state from a normal pregnancy is unknown, and relies upon arbitrary cut off criteria

https://www.ludc.lu.se/education-training/theses/theses-2017/gestational-diabetes-mellitus-north-india - 2025-05-13

The role of cocaine- and amphetamine-regulated transcript in endocrine cells Type 2 diabetes (T2D) is a metabolic disease characterized by insufficient insulin secretion and insulin resistance. Disturbed beta-cell function is the final culprit that leads to the development of T2D. In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. The aim of this thesis was to study

https://www.ludc.lu.se/education-training/theses/theses-2017/role-cocaine-and-amphetamine-regulated-transcript-endocrine-cells - 2025-05-13

Gestational Diabetes Mellitus - Diagnostic Implications during Pregnancy and follow-up The overall objective of the present thesis was to assess diagnostic implications for diagnosis of gestational diabetes (GDM) during pregnancy (Papers I and V) and for diagnosis of type 2 diabetes at follow-up after pregnancy (Papers II and IV), and the relative contriubtions of maternal body mass index (BMI) an

https://www.ludc.lu.se/education-training/theses/theses-2017/gestational-diabetes-mellitus-diagnostic-implications-during-pregnancy-and-follow - 2025-05-13

The Botnia study The Botnia study was initiated in 1990 on the western coast of Finland in the Gulf of Bothnia with the aim to:Characterize the early metabolic defects in individuals at risk of developing type 2 diabetesIdentify genetic variants predisposing to type 2 diabetesStudy how the identified genetic markers and biomarkers can predict the development of type 2 diabetes and progression of t

https://www.ludc.lu.se/resources/cohorts/botnia-0 - 2025-05-13

The genetic spectrum of diabetesAn important aim of this Initiative is to provide a gene atlas of T2D. Together with co-workers at the Broad Institute (MIT/Harvard) and Novartis we will perform a SNP genome wide association study using 500,000 SNPs on an Affymetrix chip in 1500 Scandinavian patients with T2D and 1500 non-diabetic control subjects. We expect at least 1500 SNPs (1.5%) to show nomina

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/genomics - 2025-05-13

Project areas

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas - 2025-05-13

Link to user agreement and fees confocal platform (pdf file in English) Link to user agreement and fees confocal platform (pdf file in Swedish) user_instructions_must_read.pdf lsm_800_confocal_power_pack.pdf en_wp_airyscan-detector.pdf service_descriptions_premium.pdf Related information Mouse rettinal microvessels optical_sectioning_techniques_zeiss_training_slides.pdf - presentation by Dr. Sebas

https://www.ludc.lu.se/resources/confocal-platform - 2025-05-13

Metabolic and inflammatory pathwaysCross-talk between metabolic and inflammatory pathways contributes to the pathology in many, if not most, forms of diabetes and its complications. In humans it is not possible to extract mechanistic information on how inherited defects in autoimmune/ inflammatory and metabolic pathways interact to cause damage to β-cells and target cells, culminating in diabetes.

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/inflammation - 2025-05-13

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https://www.ludc.lu.se/research-0/genomics-diabetes-and-endocrinology/affiliated-researchers/joao-fadista-phd - 2025-05-13

Molecular Etiology of Graves´ Disease and Associated Ophthalmopathy Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we de

https://www.ludc.lu.se/education-training/theses/theses-2010/tereza-planck - 2025-05-13

The Role of Genetic Variation and DNA Methylation in Human Glucose Metabolism and Type 2 Diabetes The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thes

https://www.ludc.lu.se/education-training/theses/theses-2010/tina-ronn - 2025-05-13

New aspects of voltage-gated calcium channel regulation in pancreatic beta-cells. Relevance for insulin release and type 2 diabetes Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose low

https://www.ludc.lu.se/education-training/theses/theses-2011/thomas-reinbothe - 2025-05-13

Triggers of autoimmunity. Studies on gestational events The primary aim of this thesis was to test whether gestational exposure to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure to viruses or other environmental factors is a risk factor for type 1 diabetes in the offspring. As children with type 1 diabetes have a higher risk of deve

https://www.ludc.lu.se/education-training/theses/theses-2011/sabina-lindehammer - 2025-05-13

Adaptive immune responses in atherosclerosis: Or how to prolong the use of your yellow socks Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is

https://www.ludc.lu.se/education-training/theses/theses-2011/daniel-kolbus - 2025-05-13

Genetic Variants and the Risk of Type 2 Diabetes Type 2 diabetes is rapidly increasing worldwide thereby posing a severe burden on individual and public health. Although this increase can be ascribed to both genetic and environmental factors, until 2007, the genetic factors have been largely restricted to a few candidate genes based upon our limited knowledge of the pathogenesis of the disease. In

https://www.ludc.lu.se/education-training/theses/theses-2011/anna-jonsson - 2025-05-13

Search for molecular and metabolic mechanisms contributing to impaired bet-cell function Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for

https://www.ludc.lu.se/education-training/theses/theseis-2012/siri-malmgren - 2025-05-13

Exocytosis in Type 2 Diabetes - Functional and Genetic Studies of Hormone Secretion Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts

https://www.ludc.lu.se/education-training/theses/theses-2012/sofia-andersson - 2025-05-13

Genetic and Epigenetic Influence on Oxidative Phosphorylation, Islet Function and Type 2 Diabetes in Humans The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistanc

https://www.ludc.lu.se/education-training/theses/theses-2012/anders-h-olsson - 2025-05-13

Melatonin Receptors in pancreatic Islets - Linking a Genetic Variant Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous effo

https://www.ludc.lu.se/education-training/theses/theses-2012/cecilia-nagorny-holmberg - 2025-05-13

Detecting the Vulnerable Plaque Myocardial infarction and stroke, mainly caused by a rupture of an atherosclerotic plaque, are two of the most common causes of mortality and morbidity in the world. Previous studies have pointed out inflammation, drivenby inflammatory lipids, as the keystone in the formation of the rupture prone vulnerable plaque. The risk for a plaque rupture is greatly enhanced i

https://www.ludc.lu.se/education-training/theses/theses-2013/andreas-edsfeldt - 2025-05-13