The focus of Hindrik Mulder’s research is on the metabolism of insulin-producing beta cells. The question he studies is what goes wrong in type 2 diabetes: why do the insulin-producing beta cells fail? Why are they no longer able to release as much insulin as is needed to keep blood sugar levels under control? “The cells’ powerhouses – mitochondria – play a key role in this. The mitochondria give

https://www.ludc.lu.se/dantes-circles-hell-academic-freedom - 2025-05-13

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https://www.ludc.lu.se/research-0/molecular-epidemiology-and-cardiology/maya-karbalaei-sadegh-phd - 2025-05-13

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https://www.ludc.lu.se/research-0/molecular-epidemiology-and-cardiology/anna-egerstedt-md - 2025-05-13

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https://www.ludc.lu.se/research-0/molecular-epidemiology-and-cardiology/grunde-gjesdal-md - 2025-05-13

The Botnia study was initiated in 1990 on the western coast of Finland in the Gulf of Bothnia with the aim to:Characterize the early metabolic defects in individuals at risk of developing type 2 diabetesIdentify genetic variants predisposing to type 2 diabetesStudy how the identified genetic markers and biomarkers can predict the development of type 2 diabetes and progression of the diseaseIdentif

https://www.ludc.lu.se/botnia - 2025-05-13

Aida Koder HamidEsther González Padilla

https://www.ludc.lu.se/research-0/nutritional-epidemiology/summer-students - 2025-05-13

Lund University Diabetes Centre Industrial Research Centre (LUDC-IRC) is an Industrial Research Centre for personalized medicine in diabetes.Vision: The right prevention and treatment, for the right patients at the right time.Mission: A holistic approach towards improved diagnosis, prevention and treatment of diabetes.Funding (2017-2024): 75 MSEK from SSF. 25 MSEK from industrial partners.Number o

https://www.ludc.lu.se/ludc-irc - 2025-05-13

ANDiS (All New Diabetics in Scania) is a regional research project in southern Sweden. The population of the region is just over one million. All newly diagnosed patients at all ages in the Scania region will be included during 2009-2013.The aim of the registry is to describe the spectrum of diabetes subgroups in southern Sweden and to link genetic and phenotypic information at diagnosis of diabet

https://www.ludc.lu.se/andis - 2025-05-13

Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will

https://www.ludc.lu.se/education-training/theses/theses-2017/jones-ofori - 2025-05-13

Gestational Diabetes Mellitus in North India Gestational diabetes mellitus(GDM) defines an unhealthy state of hyperglycaemia that develops in response to an otherwise normal physiological adaptive insulin resistance state during pregnancy. However, the exact plasma glucose levels differentiating the unhealthy GDM state from a normal pregnancy is unknown, and relies upon arbitrary cut off criteria

https://www.ludc.lu.se/education-training/theses/theses-2017/gestational-diabetes-mellitus-north-india - 2025-05-13

The role of cocaine- and amphetamine-regulated transcript in endocrine cells Type 2 diabetes (T2D) is a metabolic disease characterized by insufficient insulin secretion and insulin resistance. Disturbed beta-cell function is the final culprit that leads to the development of T2D. In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. The aim of this thesis was to study

https://www.ludc.lu.se/education-training/theses/theses-2017/role-cocaine-and-amphetamine-regulated-transcript-endocrine-cells - 2025-05-13

Gestational Diabetes Mellitus - Diagnostic Implications during Pregnancy and follow-up The overall objective of the present thesis was to assess diagnostic implications for diagnosis of gestational diabetes (GDM) during pregnancy (Papers I and V) and for diagnosis of type 2 diabetes at follow-up after pregnancy (Papers II and IV), and the relative contriubtions of maternal body mass index (BMI) an

https://www.ludc.lu.se/education-training/theses/theses-2017/gestational-diabetes-mellitus-diagnostic-implications-during-pregnancy-and-follow - 2025-05-13

The Botnia study The Botnia study was initiated in 1990 on the western coast of Finland in the Gulf of Bothnia with the aim to:Characterize the early metabolic defects in individuals at risk of developing type 2 diabetesIdentify genetic variants predisposing to type 2 diabetesStudy how the identified genetic markers and biomarkers can predict the development of type 2 diabetes and progression of t

https://www.ludc.lu.se/resources/cohorts/botnia-0 - 2025-05-13

The genetic spectrum of diabetesAn important aim of this Initiative is to provide a gene atlas of T2D. Together with co-workers at the Broad Institute (MIT/Harvard) and Novartis we will perform a SNP genome wide association study using 500,000 SNPs on an Affymetrix chip in 1500 Scandinavian patients with T2D and 1500 non-diabetic control subjects. We expect at least 1500 SNPs (1.5%) to show nomina

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/genomics - 2025-05-13

Project areas

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas - 2025-05-13

Link to user agreement and fees confocal platform (pdf file in English) Link to user agreement and fees confocal platform (pdf file in Swedish) user_instructions_must_read.pdf lsm_800_confocal_power_pack.pdf en_wp_airyscan-detector.pdf service_descriptions_premium.pdf Related information Mouse rettinal microvessels optical_sectioning_techniques_zeiss_training_slides.pdf - presentation by Dr. Sebas

https://www.ludc.lu.se/resources/confocal-platform - 2025-05-13

Metabolic and inflammatory pathwaysCross-talk between metabolic and inflammatory pathways contributes to the pathology in many, if not most, forms of diabetes and its complications. In humans it is not possible to extract mechanistic information on how inherited defects in autoimmune/ inflammatory and metabolic pathways interact to cause damage to β-cells and target cells, culminating in diabetes.

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/inflammation - 2025-05-13

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https://www.ludc.lu.se/research-0/genomics-diabetes-and-endocrinology/affiliated-researchers/joao-fadista-phd - 2025-05-13

Molecular Etiology of Graves´ Disease and Associated Ophthalmopathy Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we de

https://www.ludc.lu.se/education-training/theses/theses-2010/tereza-planck - 2025-05-13

The Role of Genetic Variation and DNA Methylation in Human Glucose Metabolism and Type 2 Diabetes The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thes

https://www.ludc.lu.se/education-training/theses/theses-2010/tina-ronn - 2025-05-13