Cartilage homeostasis: Modulation of cells and extracelllar matrix assembly
The cartilage extracellular matrix consists of the collagen network which enmeshes the large aggregating proteoglycan, aggrecan. Accessory molecules regulate the formation and maintenance of these structures. This thesis studies aspects of cartilage assembly during development and its degradation in disease, focusing on the collagen network. In the first paper, a model of cartilage degradation is
