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Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predomi
Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this study was to characterize novel patterns of immune cell infiltration in non-small cell lung cancer (NSCLC) in relation to its molecular and clinicopathologic characteristics. Lymphocytes (CD3+, CD4+, CD8+, CD20+, FOXP3+, CD45RO+), macrophages (CD163+), plasma cells (CD138+), NK cells (NKp4
PURPOSE: Intrauterine undernutrition is associated with increased risk of type 2 diabetes. Children born premature or small for gestational age were reported to have abnormal retinal vascularization. However, whether intrauterine famine act as a trigger for diabetes complications, including retinopathy, is unknown. The aim of the current study was to evaluate long-term effects of perinatal famine
Professor Contact details Email: raimund [dot] muscheler [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environmental Sciences (MGeo) Service point: 16 WebpageRaimund Muschelers profile in Lund University research portalOther affiliations Professor Department of Geology Member of Strategic Research Area BECC: Biodiversity and Ecosystem services in a Changing Climate Member of Stra
https://www.geology.lu.se/raimund-muscheler - 2026-05-04
Professor Physical Geography with a specialisation in remote sensingContact details Email: lars [dot] eklundh [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environmental Sciences (MGeo) Service point: 16 WebpageLars Eklundhs profile in Lund University research portalOther affiliations Professor Dept of Physical Geography and Ecosystem Science Teaching staff Dept of Physical Geogr
https://www.nateko.lu.se/lars-eklundh - 2026-05-04
Professor, Docent Contact details Email: emily [dot] boyd [at] LUCSUS [dot] lu [dot] se Phone: +46 46 222 03 69Organisation LUCSUS (Lund University Centre for Sustainability Studies) Visiting address: Biskopsgatan 5, Lund Room number: Josephson 108 Service point: 59 WebpageEmily Boyds profile in Lund University research portalOther affiliations Deputy coordinator LU Profile Area: Nature-based futu
https://www.lucsus.lu.se/emily-boyd - 2026-05-04
ANNUAL REPORT 2018 CONTENTS FOREWORD 2018 IN BRIEF PEOPLE SELECTED HIGHLIGHTS PER AREA NEWS 2018 VISIBILITY WORLDWIDE SHARING KNOWLEDGE INFRASTRUCTURE EDUCATION & OUTREACH SCIENTIFIC PUBLICATIONS 2018 NANOLUND AWARDS GRADUATE EDUCATION FUNDING ORGANISATION . . . . . . . . . . . . . . . . . . . . . . . . . 2 . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . . . . . . . . . . . . .
https://www.nano.lu.se/sites/nano.lu.se/files/2018_arsrapport_nanolund1.pdf - 2026-05-05
Post-Growth on the Move The Environmental Movement as Agent of Change for the Transition to a Post-Growth Economy - Evidence from Germany Anja Humburg anja.humburg@gmx.net Supervisor: Turaj Faran May 16, 2011 A thesis submitted in partial fullment of the requirements of Lund University International Master's Programme for Environmental Studies and Sustainability Science (LUMES). 1 Abstract This th
https://www.lumes.lu.se/sites/lumes.lu.se/files/humburg_anja_thesis_2011.pdf - 2026-05-05
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here th
Recent genome-wide association studies (GWASs) have identified a locus on chromosome 1p13 strongly associated with both plasma low-density lipoprotein cholesterol (LDL-C) and myocardial infarction (MI) in humans. Here we show through a series of studies in human cohorts and human-derived hepatocytes that a common noncoding polymorphism at the 1p13 locus, rs12740374, creates a C/EBP (CCAAT/enhancer
An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to stud
ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers (similar to 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS
Background Epithelial damage, repair and remodelling are critical features of chronic airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged airway epithelia causes inflammation via its receptor, serum stimulation-2 (ST2). Oxidation of IL-33 to a non-ST2-binding form (IL-33ox) is thought to limit its activity. We investigated whether IL-33
Retrotransposons are mobile DNA sequences duplicated via transcription and reverse transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons can also promote the transcription of adjacent genes. Somatic LINE-1 (L1) retrotransposon insertions have been detected in mammalian neurons. It is, however, unclear whether L1 sequences are mobile in only some neuronal lineage
BACKGROUND: Guidelines recommend measuring blood pressure (BP) in both arms, adopting the higher arm readings for diagnosis and management. Data to support this recommendation are lacking. We evaluated associations of higher and lower arm systolic BPs with diagnostic and treatment thresholds, and prognosis in hypertension, using data from the Inter-arm Blood Pressure Difference - Individual Partic
Sepsis is the major cause of mortality across intensive care units globally, yet details of accompanying pathological molecular events remain unclear. This knowledge gap has resulted in ineffective biomarker development and suboptimal treatment regimens to prevent and manage organ dysfunction/damage. Here, we used pharmacoproteomics to score time-dependent treatment impact in a murine Escherichia
Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 stool BAs in two population-based cohorts (TwinsUK, n = 2,382; ZOE PREDICT-1, n = 327) and assess changes post-bariatric surgery and after nutritional
Professor Kontaktinformation E-post: lars [dot] eklundh [at] mgeo [dot] lu [dot] seOrganisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsLars Eklundhs profil i Lunds universitets forskningsportalAndra roller Professor Institutionen för naturgeografi och ekosystemvetenskap Lärare Institutionen för naturgeografi och ekosystemvetenskap Medlem i Strategiskt forskningsom
https://www.nateko.lu.se/sv/lars-eklundh - 2026-05-04
Lund University Masters in Environmental Studies and Sustainability Science Dealing with change, complexity and uncertainty in global climate change negotiations – is adaptiveness the answer? A Thesis submitted to Lund University in partial fulfilment of the requirements for the degree of MASTER OF SCIENCE International Master’s Programme in Environmental Studies and Sustainability Science (LUMES)
https://www.lumes.lu.se/sites/lumes.lu.se/files/hollins_livia_thesis2_2010.pdf - 2026-05-05
