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Long-term efficacy and safety of subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors

Despite current therapies, there remains an unmet need for treatment for patients with hemophilia. The main parts of two phase 2 trials established clinical proof-of-concept for once-daily, subcutaneous concizumab prophylaxis in patients with hemophilia A/B with inhibitors (HAwI/HBwI; explorer4) and severe hemophilia A without inhibitors (HA; explorer5). Here, we present results from extension par

Genetically proxied impaired GIPR signaling and risk of 6 cancers

Preclinical and genetic studies suggest that impaired glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling worsens glycemic control. The relationship between GIPR signaling and the risk of cancers influenced by impaired glucose homeostasis is unclear. We examined the association of a variant in GIPR, rs1800437 (E354Q), shown to impair long-term GIPR signaling and lower circulatin

Programme

Programme PROGRAMME —————————————————————————— TRADITION IS THE NEW RADICAL: REMAPPING MASCULINITIES AND FEMININITIES IN THEOLOGY December 12th 13.00-14.00 Registration opens, Entrance of the LUX building 14.00-14.30 Opening of the conference, LUX C216 14.30-16.00 Plenary session I: Key-note by Tina Beattie, "Maternal Matters: Eve, Woman and the Genesis of Gender”, LUX C126 16.00-16.30 Coffee 16.3

https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/Programme-Tradition_is_the_New_Radical.pdf - 2026-04-30

COP27 Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law

COP27 Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme Work Methods Fo

https://rwi.lu.se/news-tags/cop27/ - 2026-05-03

AIML WS 20180529 handout 1s

Microsoft PowerPoint - AI dagen LUCE AIML@LU Kick-off WS 29 MAY 2018 AIML@LU • Already a lot of activity within AI an ML – Historically – at Lund University – within industry and society in the region. – As will be shown today • What can a network help with? – Stronger network (for new courses, research, innovations) – Communication – … • How should we develop the network? Agenda AM 10:15-12:00 In

https://www.ai.lu.se/sites/ai.lu.se/files/2021-03/AIML_WS_20180529_handout_1s.pdf - 2026-05-03

MÅNADSBREV- APRIL

MÅNADSBREV- APRIL MÅNADSBREV- APRIL MODEVETENSKAP AV MODEVETENSKAPLIGA STUDIERÅDET EN LUGNARE MÅNAD Vi hoppas att ni alla haft en härlig påsk och att ni fått njuta lite av det varmare vädret som börjat komma! För oss i MVS har månaden varit en lugn sådan med fokus på ansökningar, men även en hel del tentor för oss alla utanför studierådets verksamhet. Därav har vi valt att göra en mode-recap om hä

https://www.kultur.lu.se/fileadmin/user_upload/kultur/Utbildning/Mode_maanadsbrev/MA__NADSBREV-_APRIL_2021.pdf - 2026-05-02

A new look at the error-correcting capabilities of convolutional codes

This paper describes the error-correcting capability of a convolutional code when transmitting close to capacity. We show that it is the combination of average burst length and first event error probability that allows us to better describe the error-correcting capability of a code

The γ∗γ∗→ ηc (1S; 2S) transition form factor from quarkonium wave functions

We discuss γ ∗γ ∗→ ηc(1S) ; ηc (2S) transition form factor for both virtual photons. The general formula is given. We use difierent models for the cc̄ wave function obtained from the solution of the Schrödinger equation for diffierent cc̄ potentials: harmonic oscillator, Cornell, logarithmic, power-law, Coulomb and Buchmüller{Tye. We showed some examples of wave functions in the Light Front repres

Equatorial Ligand Perturbations Influence the Reactivity of Manganese(IV)-Oxo Complexes

Manganese(IV)-oxo complexes are often invoked as intermediates in Mn-catalyzed C-H bond activation reactions. While many synthetic MnIV-oxo species are mild oxidants, other members of this class can attack strong C-H bonds. The basis for these reactivity differences is not well understood. Here we describe a series of MnIV-oxo complexes with N5 pentadentate ligands that modulate the equatorial lig

Outcome measures for adult and pediatric hemophilia patients with inhibitors

Recent advancements in almost all aspects of hemophilia treatment have vastly improved patient care and management, and new and emerging treatments hold the promise of further progress. However, there remains a scarcity of data on long-term outcomes in hemophilia, particularly among those patients with inhibitors, for whom no validated outcome assessment tools are currently available. At the 15th

Heat gain from thermal radiation through protective clothing with different insulation, reflectivity and vapour permeability

The heat transferred through protective clothing under long wave radiation compared to a reference condition without radiant stress was determined in thermal manikin experiments. The influence of clothing insulation and reflectivity, and the interaction with wind and wet underclothing were considered. Garments with different outer materials and colours and additionally an aluminised reflective sui

Prokrastinering ur ett aktivitetsvetenskapligt och arbetsterapeutiskt perspektiv - En litteraturstudie om uppskjutande av aktiviteter

Bakgrund: Prokrastinering är uppskjutande av utförande av aktivitet trots vetskapen om att det kan ge negativa konsekvenser i längden. Det är ett fenomen som är väl beforskat inom den vetenskapliga disciplinen psykologi men i stort sett outforskat inom arbetsterapin och aktivitetsvetenskapen. Syfte: Syftet med denna studie var att kartlägga prokrastinering samt förekommande behandlingar ur ett aktBackground: Procrastination is the postponement of performance of an activity despite the knowledge that it can have negative consequences in the long run. It is a phenomenon that is well researched in the scientific discipline of psychology but largely unexplored in occupational therapy and occupational science. Aim: The aim of this study was to map procrastination and existing treatments from th

Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.

Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has

Calculation of Clothing Insulation by Serial and Parallel Methods: Effects on Clothing Choice by IREQ and Thermal Responses in the Cold

Cold protective clothing was studied in 2 European Union projects. The objectives were (a) to examine different insulation calculation methods as measured on a manikin (serial or parallel), for the prediction of cold stress (IREQ); (b) to consider the effects of cold protective clothing on metabolic rate; (c) to evaluate the movement and wind correction of clothing insulation values. Tests were ca

Transdiagnostic links of reward processing in obsessive-compulsive disorder and depression

ObjectivesTransdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in i

Cryogenic Trapping Effects in GaN-HEMTs : Influences of Fe-Doped Buffer and Field Plates

This article investigates trapping mechanisms in AlGaN/GaN high electron mobility transistors (HEMTs) at cryogenic temperatures (CTs) down to 4.2 K, using pulsed I–V and drain current transient spectroscopy (DCTS) measurements. The results revealed an overall increase of trapping effects at CT. In particular, a substantial increase in current collapse at low temperatures was observed and predomina

Handläggning av idrottsrelaterad hjärnskakning hos vuxna

Early recognition and management of sports-related concussion (SRC), including removal from the sports activity, is essential for player safety and to prevent long-term symptoms. A graduated, stepwise rehabilitation protocol is implemented to allow the athlete to return to sports. In 2022, the 6th international consensus statement on concussion in sports was presented, which has now been adapted t

Malmö Breast ImaginG database: objectives and development

PurposeWe describe the design and implementation of the Malmö Breast ImaginG (M-BIG) database, which will support research projects investigating various aspects of current and future breast cancer screening programs. Specifically, M-BIG will provide clinical data to: 1. investigate the effect of breast cancer screening on breast cancer prognosis and mortality; 2. develop and validate the use of a

Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1

Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed