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Field-grown genetically engineered and wild-type poplars were pyrolyzed in a micro-pyrolysis (Py-GC/MS) setup under fast pyrolysis conditions. Poplars (Populus tremula x P. alba) down-regulated for cinnamoyl-CoA reductase (CCR), which catalyzes the first step of the monolignol-specific branch of the phenylpropanoid biosynthetic pathway, were grown in field trials in France and harvested after a fu
Galectin-9 consists of two peptide-linked carbohydrate recognition domains (CRDs), but alternative splicing and proteolytic processing can give rise to multiple galectin-9 isoforms. Some of these consist of a single CRD and can exert different functions in cell biology. Here, we explored the role of these galectin-9 isoforms in endothelial cell function and angiogenesis. For this, we compared the
In this manuscript, we demonstrate the potential of replacing the standard bottom anti-reflective coating (BARC) with a polymethylglutarimide (PMGI) layer for wafer-scale nanofabrication by means of deep-UV displacement talbot lithography (DTL). PMGI is functioning as a developable non-UV sensitive bottom anti-reflective coating (DBARC). After introducing the fabrication process using a standard B
Background: Factor VIII (FVIII) trough levels > 1 IU/dL in patients with severe hemophilia A receiving regular prophylaxis may optimize bleed protection. Objectives: In this post hoc analysis of patients receiving tertiary prophylaxis for approximately 1 year, the relationship between estimated FVIII levels and reported bleeds was investigated to predict the potential for zero bleeds. Methods: Six
5G promises to usher in the industrial 4.0 era. In that era, intricately managed autonomous industrial sites with for example remotely controller equipment and autonomous units promise previously unseen levels of efficiency. Although such scenarios are elusive, they come with strict long-since established safety requirements. To uphold such requirements, intelligent industrial 5G networks, that ac
During the COVID-19 pandemic, we are likely to see a significant increase in the requests for rapid assessment of cardiac function, due to the frequent pre-existence of cardiac pathologies in patients admitted to hospital, and to the emergence of specific cardiac manifestations of this infection, such as myocarditis, sepsis related cardiomyopathy, stress induced cardiomyopathy and acute coronary s
For patients with end-stage heart failure, the use of mechanical circulatory support has increased in the last decade due to improved outcomes with durable left ventricular assist devices. The management of these complex patients requires coordinated care by a multidisciplinary team including cardiac electrophysiologists because atrial and ventricular arrhythmias are prevalent in this population.
BACKGROUND: Several different IgA-proteases exist in Haemophilus influenzae. The variants have been suggested to play differential roles in pathogenesis, but there is limited information on their distribution in clinical isolates. The objective of this study was to investigate the distribution of IgA-protease genotypes in H. influenzae and assess the association between IgA-protease genotype and t
The need for robust estimates of times of divergence is essential for downstream analyses, yet assessing this robustness is still rare. We generated a time-calibrated genus-level phylogeny of butterflies (Papilionoidea), including 994 taxa, up to 10 gene fragments and an unprecedented set of 12 fossils and 10 host-plant node calibration points. We compared marginal priors and posterior distributio
Background Athletes competing in athletics (track and field) at international level may be participating with underlying undiagnosed life-threatening cardiovascular conditions. Our objective was to analyse variations in pre-participation cardiac evaluation prevalence among athletes participating in two International Association of Athletics Federations (IAAF) World Athletics Championships, with re
Background: Sequencing parasite genomes in the presence of host DNA is challenging. Sequence capture can overcome this problem by using RNA probes that hybridize with the parasite DNA and then are removed from solution, thus isolating the parasite DNA for efficient sequencing. Methods: Here we describe a set of sequence capture probes designed to target 1035 genes (c. 2.5 Mbp) of the globally dist
OBJECTIVE: Although injury burden prompts elite athletics (track and field) athletes to engage in injury management, little is known about their health literacy. We investigated musculoskeletal (MS) health literacy in world-leading athletics athletes and associations with prechampionship injury acknowledgement by reduction of training load in different socioeconomic environments.METHODS: Adult and
PURPOSE: The intracorporeal anastomosis (IA) technique possibly results in enhanced recovery and reduced morbidity rates compared to the extracorporeal anastomosis (EA) technique. This study compared the short-term morbidity rates of IA versus EA in segmental resections for colon cancer.METHOD: We performed a retrospective cohort study of consecutive patients from 2015 to 2020 using the IA or EA t
Background: Multidisciplinary team meetings (MDTMs) provide an integrated team approach to ensure individualized and evidence-based treatment recommendations and best expert advice in cancer care. A growing number of patients and more complex treatment options challenge MDTM resources and evoke needs for case prioritization. In this process, decision aids could provide streamlining and standardize
Avian Malaria infects thousands of species of birds across the Aves class. The most widespread (geographically and phylogenetically)morphological species is Plasmodium relictum, and of that, the mitochondrial lineage of SGS1 is the most common and invasive. It infects146 bird species, with large differences in infection outcome, from low intensity chronic disease to shorter, highly virulent infect
PURPOSE: Breast cancer screening is predominantly performed using digital mammography (DM), but digital breast tomosynthesis (DBT) has higher sensitivity. DBT demands more resources than DM, and it might be more feasible to reserve DBT for women with a clear benefit from the technique. We explore if artificial intelligence (AI) can select women who would benefit from DBT imaging.APPROACH: We used
Adaptive reuse of buildings, repurposing existing structures for new functions, is gaining attention for its potential in sustainable development and optimisation of building materials usage. This practice is particularly relevant in the building sector, where space heating, ventilation, and air conditioning (HVAC) systems represent a significant portion of project costs, embodied energy, greenhou
Background: Hemophilia B is a genetic bleeding disorder caused by a deficiency of clotting factor IX, which presents unique challenges in clinical management. Advances in therapeutic strategies for hemophilia B have significantly improved patient outcomes but have also necessitated ongoing education for healthcare professionals. This illustrated review provides an overview of the challenges and op
Abstract in French Cette etude reprend les resultats d'une recherche co-financee par la Communaute Europeenne sur les effets thermiques des vetements de protection et sur l'astreinte physiologique qui en resulte dans les conditions de travail. L'etude concerne l'infiuence de l'asymetrie de rayonnement thermique. L'echange thermique a ete mesure al'aide d'un mannequin calorimetrique sous l'influencThis report considers results of an ED funded research on thermal properties ofprotective clothing and their use in the assessment of the thermal strain at work. In order to study the effects of the asymmetry oflong wave thermal radiation on the heat transfer through protective clothing, the heat loss under all-side and unilaterally applied radiation with the same incident radiant power of 279 W/m
