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In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. This work is aimed to study the enrichment of cer
Smittspridning i ventilerad inomhusmiljö har sedan Covid-19 pandemin startade blivit ett högaktuellt ämne. Smittan som uppstod i Kina spred sig snabbt över hela världen och gav upphov till omfattande restriktioner och förändringar i det vardagliga livet för miljarder människor. Till en början antogs Covid-19 endast spridas via dropp- och kontaktsmitta men forskning och kända utbrott visar att luftThe transmission of airborne aerosols in a ventilated indoor environment has become highly relevant since the Covid-19 outbreak. Initially, Covid-19 was only assumed to be spread via droplet and contact infection, but research and known outbreaks show that airborne transmission via aerosols occurs. Modern humans spend a large part of their life indoors. Understanding and calculating how virus-carr
There is an ongoing shift to mobility in business IT, as well as in the consumer space. Users do not demand mobile availability anymore, they simply expect the ability to access business IT with consumer devices. Stemming from this demand, mobile business intelligence (BI) has emerged as a response from the BI industry. Thus, mobile BI is an extension of traditional BI into mobile devices. In line
Syftet med uppsatsen är att undersöka hur ett företags aktiekurs påverkas under de första handelsdagarna efter en börsintroduktion och om det förekommer en underprissättning. Vi vill vidare undersöka de mekanismer som ligger bakom en introduktion och vilka faktorer som spelar in på den initiala kursförändringen. Vår ansats har varit deduktiv och vi har använt oss av både en kvantitativ och en kval
The oil and gas industry is an activity that simultaneously resembles formula one and space missions. By the formula one´s side, it operates close to technological limits. And by the space missions’ side, several experimental or semi-experimental technologies are broadly used. O&G industry is indeed a high-risk socio-technical system.” (Eder Henriqson, personal communication) Such a statement
Att byggsektorn står inför ett rådande klimatnödläge är ett faktum. Idag investeras hundratals miljarder kronor för att i framtiden kunna producera fossilfritt stål; trots det läggs lite fokus på miljöoptimering av konstruktioner. Syftet med arbetet är att utvärdera hur parametrisk design kan användas som verktyg för att miljöoptimera stålstommar i industritrapptorn samt undersöka vilken profiltypThe fact that the construction sector faces a prevailing climate emergency is undeniable. Today, hundreds of billions of kronor are being invested to develop fossil-free steel; yet little focus is placed on environmental optimization of constructions. The purpose of this work is to evaluate how parametric design can be used as a tool for environmental optimization of steel staircase towers, as wel
This thesis explores the employer branding strategies of four major student nations at Lund University through their Instagram content throughout the year 2023. The focus is on how these organizations leverage organizational culture and rhetorical strategies—ethos, pathos, and logos—to engage current and prospective members. Utilizing a qualitative content analysis, it is examined how each student
In 2018 90 billion tonnes of raw material was extracted globally. It is estimated 20% of this went to waste and with the quickening pace of global metabolism this figure is predicted to have doubled by 2060. In the context of the Anthropocene we need to reduce this incessant cycle of mass extraction and production of waste, change the production systems from linear to cyclic and prove for industri
Motivation: Human pluripotent stem cell lines persist in culture as a heterogeneous population of SSEA3 positive and SSEA3 negative cells. Tracking individual stem cells in real time can elucidate the kinetics of cells switching between the SSEA3 positive and negative substates. However, identifying a cell's substate at all time points within a cell lineage tree is technically difficult. Results:
Patients with biventricular assist devices (BIVAD) are severely critically ill compared with patients who receive left ventricular assist device (LVAD) support alone and portend a significant risk for greater adverse events including pump thrombosis (PT). Current approaches to treat PT are limited to LVAD with variable outcomes depending on the management strategy implemented. Moreover the managem
Risk and return go hand in hand, and one way for a firm to mitigate existing and potential investors' risk in a stock is to employ a financial service; liquidity providing. The value of liquidity provision has become relevant as market uncertainties and shocks in the market create disturbances. In addition, the market environment has changed with regulation and the increase of high-frequency t
Denna uppsats undersöker hur Lean Startup-principer kan stödja snabb filtrering och tidig validering av entreprenöriella idéer i osäkra sammanhang. Även om det empiriska fokuset ligger på digital finansiell utbildning för unga yrkesverksamma, är det övergripande målet att bedöma om en strukturerad, hypotesdriven metodik kan främja välinformerat beslutsfattande i de tidiga faserna av affärsutveckliThis thesis explores how Lean Startup principles can support the rapid filtering and early validation of entrepreneurial ideas in uncertain contexts. While the empirical focus is placed on digital financial education for young professionals, the broader objective is to assess whether a structured, hypothesis-driven methodology can support informed decision-making in the early stages of venture des
Generative AI (GenAI) tools have seen rapid adoption in software development teams, yet research has focused almost exclusively on individual-level outcomes such as productivity and task completion speed. The consequences for how teams coordinate expertise remain unexplored. This study examines what the affordances and constraints of GenAI tools are for software development teams and how they inte
BACKGROUND: Several reports have been published on the gender differences associated with allergies in mice. GOAL: In the present study we investigate the influence of gender on allergy response using a strain of mice, B10.RIII, which is commonly used in the collagen-induced arthritis murine model. METHODS: Both male and female B10.RIII young mice were immunized with OVA and challenged four times
The rapid rise of an innovative private manufacturing economy in China challenges standard economic explanations of growth, which typically assume the existence of well-defined formal institutions such as property rights and company laws safeguarding investor and creditor interests. We highlight the social structure of cooperation that enables innovative activity in private manufacturing firms whe
Atomic (1 Å) resolution x-ray structures of horse liver alcohol dehydrogenase in complex with NADH revealed the formation of an adduct in the active site between a metal-bound water and NADH. Furthermore, a pronounced distortion of the pyridine ring of NADH was observed. A series of quantum chemical calculations on the water-nicotinamide adduct showed that the puckering of the pyridine ring in the
Economic institutions enabling trust and cooperation rest on multiplex networks and norms of reciprocity. A key feature of economic institutions is that they facilitate commercial transactions by reducing uncertainty and risk in markets. When trust and trustworthiness stem from confidence in community sanctions of norms, principal and agent relations are enforceable without resorting to legal rule
