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The use of substrate analogues as inhibitors provides a way to understand and manipulate enzyme function. Here we report two 1 A resolution crystal structures of liver alcohol dehydrogenase in complex with NADH and two inhibitors: dimethyl sulfoxide and isobutyramide. Both structures present a dynamic state of inhibition. In the dimethyl sulfoxide complex structure, the inhibitor is caught in tran
The photon-number statistics from resonance fluorescence of a two-level atom near a metal nanosphere driven by a laser field with finite bandwidth is studied theoretically. Our analysis shows that all interesting physics here takes place in a small area around the nanosphere where the near field and the atom-nanosphere coupling essentially affect the radiative properties of the atom. Computer mode
In this paper several rate R = 2/5 convolutional encoding matrices with four states are used to illustrate how unequal error protection can be achieved for the different positions in the code sequences as well as in the information sequences. Free output- and input-distances and active burst output- and input-distances are computed. Typically a single code cannot combine a large free output- or in
Comparative studies of corruption focus on the selection and incentives of policymakers. With few exceptions, actors who are in charge of implementing policies have been neglected. This article analyzes an original data set on the bureaucratic features and its effects on corruption in fifty-two countries. Two empirical findings challenge the conventional wisdom in literature. First, certain bureau
The laccase producing fungus HC1 was isolated from a sample collected in the Bolivian Amazon region. Analysis of 5.8S and 28S rDNA, and internal transcribed spacer 1 and 2 sequences revealed that isolate HC1 belongs to genus Galerina. High production of laccase was achieved in basal salt medium supplemented with 30 g L-1 glucose, 10 g L-1 yeast extract and 0.01 g L-1 co
During the 1980s the word ’postmodernism’ was inserted into the dicourse of Swedish literature in a curious way. Even though both writers and critics found the word bewildering – or deemed it a buzzword devoid of meaning – it sparked fierce debates. Despite this, and despite the fact that few wanted to be associated with the word, it has become common to describe the 1980s as the era of Swedish li
We discuss γ∗γ∗ → ηc(1S), ηc(2S) transition form factors for both virtual photons. The general formula is given. We use different models for the cc¯ wave function obtained from the solution of the Schrödinger equation for different cc¯ potentials: harmonic oscillator, Cornell, logarithmic, power-law, Coulomb and Buchmüller-Tye. We showed some examples of wave functions in the Light Front represent
A convolutional code can be used to detect or correct infinite sequences of errors or to correct infinite sequences of erasures. First, erasure correction is shown to be related to error detection, as well as error detection to error correction. Next, the active burst distance is exploited, and various bounds on erasure correction, error detection, and error correction are obtained for convolution
Objectives: This study aims to evaluate how metastases in the seven topographical regions of the simplified peritoneal cancer index (sPCI) affect the survival of patients treated with cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) from colorectal (CRC) or appendiceal cancers.Methods: Data was collected retrospectively from patient rec
Density functional theory (DFT) thermochemistry of 3d transition-metal complexes is well-known to be sensitive to the amount of exact Hartree-Fock exchange incorporated into the exchange-correlation functional. For example, relative energies of different protonation states of iron-sulfur complexes may vary by hundreds of kJ/mol among different DFT methods. In the present study, we examine the rela
Background: Microbial production of propionic acid (PA) from renewable resources is limited by the slow growth of the producer bacteria and product-mediated inhibition. The present study evaluates high cell density continuous PA fermentation from glycerol (Gly) using Acidipropionibacterium acidipropionici DSM 4900 in a membrane-based cell recycling system. A ceramic tubular membrane filter of 0.22
Resonant inelastic x-ray scattering (RIXS) is a major method for investigation of electronic structure and dynamics, with applications ranging from basic atomic physics to materials science. In RIXS applied to inversion-symmetric systems, it has generally been accepted that strict parity selectivity applies in the sub–kilo–electron volt region. In contrast, we show that the parity selection rule i
Den digitala teknikens utveckling har sedan långt tillbaka inneburit ett hot mot upphovsrätten. Under de senaste åren har Cloud Computing, eller molnbaserade datatjänster, framstått som ett allt intressantare forsknings- och tillämpningsområde inom teknikbranschen. Cloud Computing utgör en teknisk infrastruktur där användaren har tillgång till data som är belägen utanför den egna plattformen och k
France and Germany are two closely connected countries with two very different identities. Despite of these differences they have been cooperating for many years and have been a driving factor behind European integration and have had a common interest in making the European Union a global actor with a more united foreign policy. Agreement between the two countries are not an axiom though, as the i
Vid överprövning av upphandlingar gör förvaltningsrätten en skadeprövning för att bedöma om ett eventuellt fel har lett till skada för leverantören. Skadan som åberopas behöver ha en koppling till felet, och det finns även en plikt etablerad av högsta förvaltningsdomstolen för leverantörer att uppmärksamma upphandlande myndigheter när de upptäcker fel under upphandlingens anbudstid. I domen som HFIn the context of public procurement appeals, Swedish administrative courts conduct a damage assessment to determine whether a potential breach of the procurement law will justify action from the court. To be actionable, the damage must be linked to the error. Moreover, the Supreme Administrative Court has established a duty for persons participating to notify the procuring entity of any irregular
Purpose: The relationship between inconspicuous consumption and consumers’ self-identities within luxury hospitality services has been largely overlooked, which calls for further investigation. Consequently, this study aims to explore the understanding of the relationship between the phenomena of inconspicuous luxury consumption of hospitality services and individuals’ self-identities. Methodolog
