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Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genet

Human dignity is a key foundational value for human rights. Human rights are however facing new challenges from the development and deployment of artificial intelligence technologies in society. Governance efforts to address such challenges have encompassed drawing up ethical guidelines, policy measures as well as legal regulation. The world’s first comprehensive regulation on artificial intellige

A summary of the constraints from searches performed by the ATLAS collaboration for the electroweak production of charginos and neutralinos is presented. Results from eight separate ATLAS searches are considered, each using 140 fb−1 of proton-proton data at a centre-of-mass energy of s = 13 TeV collected at the Large Hadron Collider during its second data-taking run. The results are interpreted in

Extending the lifetime of products enables material resource savings and provides an effective resource efficiency strategy within a circular economy paradigm. Although consumer demand for longer lasting products that can be easily repaired has been on the rise, it is not certain that consumers are fully able to identify such products and willing to pay a premium for them. France introduced a mand

In the work of writing this report, four leading municipal research environments - CERUM, CKS, KEFU, and KFi - with the support of Kommuninvest, have collaborated to explore and understand the complex challenges that Swedish municipalities have had to manage during the transition from relatively favorable economic times to more challenging times, including changed economic conditions and a deterio

Background/Objectives:Catha edulis, also known as Khat, is a stimulant with hepatotoxic properties. Studies reporting laboratory patterns are scarce. The aim was to assess the patterns associated with hepatic dysfunction due to Khat usage. Methods: Patients with liver injury and self-reported Khat consumption presenting to the gastroenterology department at the King Fahad Central Hospital in Jazan

Background/Objectives: There is a lack of research examining healthcare professionals' perspectives regarding the potential of non-pharmacological solutions such as immersive virtual reality (VR). The aim of this study was to investigate opportunities and challenges related to the application of immersive virtual reality (VR) technology in patients aged 65 and older undergoing surgery with regiona

The speedy advancement of digital technologies in the last decade has introduced new tools, workflows and stakeholders in diplomacy, creating significant information demands and a state of “digital stress”. To navigate these challenges, diplomats employ coping strategies that leverage their reflexivity and autonomy to manage demands, prioritize tasks, and mitigate overload. Beyond merely adapting

The angular correlations between charged Ξ baryons and associated identified hadrons (pions, kaons, protons, Λ baryons, and Ξ baryons) are measured in pp collisions at s = 13 TeV with the ALICE detector to give insight into the particle production mechanisms and balancing of quantum numbers on the microscopic level. In particular, the distribution of strangeness is investigated in the correlations

A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at s = 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb, tt¯, and tb)

This paper presents the measurement of fiducial and differential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge

A comprehensive study of the local and nonlocal amplitudes contributing to the decay B0 → K*0(→ K+π−)μ+μ− is performed by analysing the phase-space distribution of the decay products. The analysis is based on pp collision data corresponding to an integrated luminosity of 8.4 fb−1 collected by the LHCb experiment. This measurement employs for the first time a model of both one-particle and two-part

Biochar has a very wide range of uses in industrial processes, wastewater treatment, agriculture and soil remediation. Scaling up biochar deposits in soils has been proposed for carbon sequestration in the context of climate mitigation strategies. Although certain contaminants in feedstock can be eliminated through pyrolysis, others persist, and the process itself produces additional hazardous sub

In this paper, I draw on my background as an educational scientist with roots in sociology and gender studies to explore how public debate, political reforms, and policy documents shape Swedish teacher education with the aim of reforming not only the school system but also Swedish society. Historically, teacher education in Sweden has been influenced by visionary ideals, particularly with the intr

The first measurements of femtoscopic correlations with the particle pair combinations π±KS0 in pp collisions at s=13 TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K0⁎(700) particle that has been considered a tetraquark candidate for over forty years. Source and final-state interacti

Luminosity determination within the ALICE experiment is based on the measurement, in van der Meer scans, of the cross sections for visible processes involving one or more detectors (visible cross sections). In 2015 and 2018, the Large Hadron Collider provided Pb-Pb collisions at a centre-of-mass energy per nucleon pair of √s NN= 5.02 TeV. Two visible cross sections, associated with particle detect