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Amid overlapping global crises, many individuals experience psychological distress, anxiety, hopelessness, and a diminished sense of agency. Scholars increasingly argue that this erosion of perceived significance may be as consequential as climate change, biodiversity loss, polarization, and political turmoil, as it stems from a growing disconnection or alienation from self, others, and nature at

Non-invasive methods for measuring thermal tolerance and thermoregulation in large numbers of individuals under natural environmental conditions are useful to understand the capacity of species to adapt to future climate scenarios. Infrared thermography (IRT) is one such tool in research on thermal adaptation, but concerns have been raised about its reliability, specifically the correlation betwee

BACKGROUND: The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity. METHODS: To evaluate the potential role of ge

OBJECTIVE: To report population-based clinical presentation and outcomes in patients with urosymphyseal fistula (USF) after pelvic radiotherapy (RT). PATIENTS AND METHODS: A retrospective chart review was performed in 33 consecutive patients diagnosed with suspicion of USF in a tertial referral center from 2014-2022 to ascertain information about diagnostic delay, clinical presentation, precipitat

Dyspnea and chest pain are major and important causes of contact at the emergency department (ED). Dyspnea is associated with high morbidity and mortality, but data on characteristics and outcomes compared with chest pain in the ED are limited. This was a retrospective cohort study of consecutive patients with contact causes of dyspnea or chest pain at two Swedish EDs from 2010 to 2014. Hospital a

In this study, laminar burning velocities (LBV) of ammonia in oxygen-enriched air (oxygen content ranging from 30 to 50 vol%) were investigated under various initial temperatures (298, 323, and 348 K) at a pressure of 1 atm, employing the heat flux method. Our measurements reveal substantial disparities with previously published data primarily obtained using the spherical flame method. The reliabi

Objective: Exercise is a first-line intervention for osteoarthritis (OA). However, exercise adherence remains low, and existing studies exploring factors influencing adherence have yielded inconclusive results based on quantitative data. This study aims to synthesise qualitative studies focused on the perceived facilitators and barriers affecting exercise adherence in individuals with OA. Design:

Irony is a heavily context-dependent pragmatic phenomenon. But what is it about context that facilitates or blocks irony comprehension? Based on the echoic account, we suggest that a context facilitates irony comprehension when it makes manifest a speaker's intentions and attitude, i.e., when a context makes it easy for participants to engage their mindreading abilities. In two pre-registered self

Age-Friendly Cities and Communities (AFCC) is a key global WHO initiative aimed at fostering environments that promote healthy aging for everyone. As AFCC initiatives continue to expand, there is an increasing need to enhance monitoring and evaluation systems to effectively assess their progress and impact. However, significant knowledge gaps persist, particularly in the development of evaluation

Contact allergy (CA) is not uncommon in the population, including to various fragrance allergens. If not diagnosed correctly, allergic contact dermatitis (ACD) may ensue, because targeted allergen avoidance is not possible. The primary objective of the study is to estimate the prevalence of CA to seven fragrance materials in patients with suspected ACD across Europe. Based on the outcome, a conclu

Simulations are an indispensable tool in physics because they complement experiments, especially complex ones. Coherent multidimensional spectroscopy (CMDS) is such a complex experimental setup. In CMDS, the molecular system of interest interacts with two to four coherent laser pulses and the generated emission provides information about the energetic structure and the relaxation dynamics of the p

The dominant narrative on equity, diversity, and inclusion in U.S. medical research emphasises the underrepresentation of Black and Hispanic participants in clinical trials, largely based on therapeutic phase 2 and 3 trials. Far less attention has been paid to phase 1 trials—particularly those involving healthy volunteers who assume health risks without therapeutic benefit, often for money. Focusi