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Background: The prognostic benefit of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in stable coronary artery disease (CAD) remains uncertain. Objectives: To evaluate long-term survival following CTO PCI compared with medical therapy (MT) using target trial emulation and a nationwide real-world registry. Methods: We included 7813 patients with stable CAD and a document
The 39.4% decline in numbers in the Northeast/Northwest European population of Bewick’s Swan Cygnus columbianus bewickii between 1995 (29,780 birds) and 2010 (18,057 birds) was of major conservation concern, alleviated by a partial recovery to 20,149 recorded in the January 2015 census. The most recent census, in January 2020, however found that the recovery was not sustained. The results describe
IntroductionSport-related concussion (SRC) is one of the most common and concerning injuries in team sports, with potential long-term effects on athlete health and performance. Linear head acceleration (LHA) and rotational head acceleration (RHA) are central biomechanical markers of brain loading during impact. Yet, the magnitude of these accelerations during SRC events remains poorly synthesized
Conventional capacity expansion planning (CEP) relies on a perfect-foresight planning horizon and linear investment optimisation, which fail to capture the non-linear dynamics of electricity markets. In the Nordics, hydro-related weather variability plays a critical role in maintaining the robustness of the power system. This paper addresses the intra-year perfect-foresight limitation in current C
Background In patients with stage III cutaneous melanoma, adjuvant treatments with PD-1 and BRAF+MEK inhibitors were approved based on improved recurrence-free survival. However, as the treatments have significant side effects and costs, the effect on overall survival remains a matter of great importance. Methods Clinical and histopathological parameters were obtained from the Swedish Melanoma Reg
Background Completion axillary lymph node dissection (cALND) is often recommended for patients with isolated tumour cells (ITCs) or micrometastases in the sentinel lymph node (SLN) or target lymph node (TLN) to assess the definite nodal tumour burden after neoadjuvant chemotherapy (NACT). The aim of this study was to investigate the upgrade of N stage by cALND in patients with low-volume metastase
Background: Policy advocacy (PA) in European healthcare has a strong tradition promoting evidence-based policies. Key organisations, including the European Observatory on Health Systems and Policies, the WHO’s Evidence-Informed Policy Network, and the OECD play pivotal roles in integrating research into policymaking. Objectives: To assess the involvement of European Family Medicine (FM) Associatio
Background The purpose of this systematic review and meta-analysis was to (i) evaluate effects of exercise on cancer-related lymphedema (CRL) incidence, and (ii) explore whether effect differed according to patient and exercise intervention characteristics. Methods A search of 6 electronic databases was undertaken to identify intervention studies published up to May 2025. Studies included individu
North Sea-Progressive Myoclonus Epilepsy (NS-PME) is a progressive neurological disorder, initially only associated with the homozygous GOSR2 founder mutation (c.430G>T; p.Gly144Trp). Clinical symptoms include untreatable early-onset ataxia, cortical myoclonus and epilepsy. Recently, the spectrum of GOSR2 mutations and associated phenotypic variability has expanded. To improve care and to facilita
Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10
Background: The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods: This review included studies published in English language from January 1st, 1990, through
Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of 0.18âà € ³ in the optical, making it an ideal instrument to search for gravitational lenses down to the limiting magnitude of 21. Nevertheless, the previous Gaia Data Releases are known to be incomplete for small angular separations such as thos
A search is conducted for new phenomena in events with a top quark pair and large missing transverse momentum, where the top quark pair is reconstructed in final states with one isolated electron or muon and multiple jets. The search is performed using the Large Hadron Collider proton-proton collision data sample at a centre-of-mass energy of s = 13 TeV recorded by the ATLAS detector that correspo
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases
Background: Parkinson's disease is a progressive neurodegenerative disorder. Awareness and the evidence supporting the merits of palliative care (PC) approaches to people with Parkinson's disease (PwP) are increasing. Objective: This review aimed to address four key questions related to PC for PwPs and their caregivers: i) What are the indicators for timely access to PC? ii) When should PC be intr
