BACKGROUND: F8 int1h inversions (Inv1) are detected in 1-2% of severe hemophilia A (HA) patients. Long-range polymerase chain reaction (PCR) and inverse-shifting PCR have been used to diagnose these inversions.OBJECTIVES: To design and validate a sensitive and robust assay for detection of F8 Inv1 inversions.METHODS: Archival DNA samples were investigated using mile-post assays and droplet digital

Handling of critical situations is an important part in the architecture of an autonomous vehicle. A controller for autonomous collision avoidance is developed based on a wary strategy that assumes the least tireroad friction for which the maneuver is still feasible. Should the friction be greater, the controller makes use of this and performs better. The controller uses an acceleration-vector ref

Segmenting a motion-planning problem into smaller subproblems could be beneficial in terms of computational complexity. This observation is used as a basis for a new sub-maneuver decomposition approach investigated in this paper in the context of optimal evasive maneuvers for autonomous ground vehicles. The recently published alternating augmented Lagrangianmethod is adopted and leveraged on, whic

This study aims at assess the importance of a conceptual representation of hydrological processes when modelling atmospheric circulation. It compares results from a regional atmospheric model that interprets land surface hydrological processes based on parameterizations with results from a two-way coupled atmosphere-hydrological model that has a process-based approach to the land surface hydrologi

HQC is an IND-CCA2 KEM running for standardization in NIST’s post-quantum cryptography project and has advanced to the second round. It is a code-based scheme in the class of public key encryptions, with given sets of parameters spanning NIST security strength 1, 3 and 5, corresponding to 128, 192 and 256 bits of classic security.In this paper we present an attack recovering the secret key of an H

Twenty-two female psychiatric outpatients with experiences of childhood sexual abuse took part in a two-year group therapy. All Completed therapy. At the end of therapy the women's psychiatric symptoms were reduced and their social interaction and adjustment were improved. They evaluated relationships to their children, partners and friends to be improved.

Cell cycle progression and lipid metabolism are well-coordinated processes required for proper cell proliferation. In liver diseases that arise from dysregulated lipid metabolism, proliferation is diminished. To study the outcome of CDK1 loss and blocked hepatocyte proliferation on lipid metabolism and the consequent impact on whole-body physiology, we performed lipidomics, metabolomics, and RNA-s

Background: In a previous study we interviewed significant others (SOs) directly following a patient's suicide attempt as a part of the psychiatric assessment. SOs added important information to the assessment and they needed professional counselling themselves. In the present study the opinions of SOs were investigated 1 year after a suicide attempt. Methods: Semi-structured interviews of 84 SOs

As part of the psychiatric assessment after a suicide attempt contact with a significant other could be of importance in order to obtain an additional view of the patient's situation, and thereby possibly broadening the basis of the assessment. The aims of this study were to investigate whether information from a significant other would be helpful in the psychiatric assessment of the patient, and

The aims of the present study were to investigate the existence of overconsumption of alcohol and tranquillizers in suicide attempters and whether overconsumers differ from those with no overconsumption. One hundred and twenty-six patients, evaluated and treated after a suicide attempt in a psychiatric ward, took part in a comprehensive investigation. This included questions on consumption of alco

During the last decades, a positive relation between a good alliance and a successful therapy outcome has been demonstrated across a variety of different therapeutic modalities. The relationship between alliance and drinking outcome in long-term treatment of alcoholics (12 months or more) has not, as far as we know, been presented. In the present study, alcoholics were randomized to two outpatient

Seventy-five patients were admitted to the ward of the Lund Suicide Research Center following a suicide attempt. After 5 years, the patients were followed up by a personal semistructured interview covering sociodemographic, psychosocial and psychiatric areas. Ten patients (13%) had committed suicide during the follow-up period, the majority within 2 years. They tended to be older at the index atte

The X-ray absorption spectrum of N2+ in the K-edge region has been measured by irradiation of ions stored in a cryogenic radio frequency ion trap with synchrotron radiation. We interpret the experimental results with the help of restricted active space multiconfiguration theory. Spectroscopic constants of the 1σu-1 ς2u+ state, and the two 1σu-13σg-11πg Π2u states are determined from the measuremen

Field measurement data on greenhouse gas (GHG) emissions are still scarce for many land-use types in Africa, causing a high level of uncertainty in GHG budgets. To address this gap, we present in situ measurements of carbon dioxide (CO2 ), nitrous oxide (N2 O), and methane (CH4) emissions from the lowlands of southern Kenya. We conducted eight chamber measurement campaigns on gas exchange from fou

The global climate transition from the Lateglacial to the Early Holocene is dominated by a rapid warming trend driven by an increase in orbital summer insolation over high northern latitudes and related feedbacks. The warming trend was interrupted by several abrupt shifts between colder (stadial) and warmer (interstadial) climate states following instabilities of the Atlantic Meridional Overturnin

50 years had passed since the introduction of the so-called safety bicycle when Kulturen's first yearbook was published in 1935. The bicycle was a common sight in everyday city life during the 1930s. Was it perhaps for this reason that it rarely featured in the yearbooks issued during the 1930s and 1940s? During these two decades it was most common to hear about them through adverts. Nonetheless t

With conventional antibiotic therapies being increasingly ineffective, bacterial infections with subsequent biofilm formation represent a global threat to human health. Here, an active and a passive strategy based on polymeric micelles were combined to fight bacterial growth. The passive strategy involved covalent immobilization of polymeric micelles through Michael addition between exposed maleim

Microbial degradation of lignin and its related aromatic compounds has great potential for the sustainable production of chemicals and bioremediation of contaminated soils. We previously isolated Pseudomonas sp. strain 9.1 from historical waste deposits (forming so-called fiber banks) released from pulp and paper mills along the Baltic Sea coast. The strain accumulated vanillyl alcohol during grow