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Coping with the Double Crisis : Lake Chilwa Recession and the Great Depression on Chisi Island in Colonial Malawi, 1930–1935
Species-specific temporal variation in photosynthesis as a moderator of peatland carbon sequestration
In boreal bogs plant species are low in number, but they differ greatly in their growth forms and photosynthetic properties. We assessed how ecosystem carbon (C) sink dynamics were affected by seasonal variations in the photosynthetic rate and leaf area of different species. Photosynthetic properties (light response parameters), leaf area development and areal cover (abundance) of the species were
Visualization of gas distribution in a model AP-XPS reactor by PLIF : Co oxidation over a Pd(100) catalyst
In situ knowledge of the gas phase around a catalyst is essential to make an accurate correlation between the catalytic activity and surface structure in operando studies. Although ambient pressure X-ray photoelectron spectroscopy (AP-XPS) can provide information on the gas phase as well as the surface structure of a working catalyst, the gas phase detected has not been spatially resolved to date,
HAMLET – A protein-lipid complex with broad tumoricidal activity
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a tumoricidal protein-lipid complex with broad effects against cancer cells of different origin. The therapeutic potential is emphasized by a high degree of specificity for tumor tissue. Here we review early studies of HAMLET, in collaboration with the Orrenius laboratory, and some key features of the subsequent development of the HAML
NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling
The Wnt signaling pathway is essential in regulating various cellular processes. Different mechanisms of inhibition for Wnt signaling have been proposed. Besides β-catenin degradation through the proteasome, nemo-like kinase (NLK) is another molecule that is known to negatively regulate Wnt signaling. However, the mechanism by which NLK mediates the inhibition of Wnt signaling was not known. In th
Dual-focus coherent anti-Stokes Raman scattering microscopy using a compact two-beam fiber laser source
We have developed a dual-focus coherent anti-Stokes Raman scattering (CARS) microscope based on a dual output, compact fiber laser source. The underlying concepts of time-multiplexed, two-beam scanning and demultiplexed detection that we already employed for second-harmonic generation are here naturally extended for CARS microscopy. The layout of a robust, all-fiber laser source was reconfigured t
Electronic structure transformation in small bare Au clusters as seen by x-ray photoelectron spectroscopy
Free bare gold clusters in the size range from few tens to few hundred atoms (≤1 nm dimensions) have been produced in a beam, and the size-dependent development of their full valence band including the 5d and 6s parts has been mapped 'on the fly' by synchrotron-based photoelectron spectroscopy. The Au 4f core level has been also probed, and the cluster-specific Au 4f ionization energies have been
Introduction to macroscopic power scaling principles for high-order harmonic generation
This tutorial presents an introduction to power scaling concepts for high-order harmonic generation (HHG) and attosecond pulse production. We present an overview of state-of-the-art HHG-based extreme ultraviolet (XUV) sources, followed by a brief introduction to basic principles underlying HHG and a detailed discussion of macroscopic effects and scaling principles. Particular emphasis is put on a
SMIM1 variants rs1175550 and rs143702418 independently modulate Vel blood group antigen expression
The Vel blood group antigen is expressed on the red blood cells of most individuals. Recently, we described that homozygosity for inactivating mutations in SMIM1 defines the rare Vel-negative phenotype. Still, Vel-positive individuals show great variability in Vel antigen expression, creating a risk for Vel blood typing errors and transfusion reactions. We fine-mapped the regulatory region located
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mic
Youth, Labour Law, and European Economic Crisis
Retrofitting Electrically Heated Single-Family Houses to Net-Zero Energy
Only in Sweden, single-family houses account for approximately 30% of energy use in all buildings and a large part uses only electricity for heating. The potential for improvements on energy efficiency in these houses is large. This study theoretically investigates retrofitting of electrically heated Swedish single-family houses by using an air-source heat pump for both space heating and domestic
Predistortion- and development-platform for multi-input RF power amplifiers
We present a real-time digital predistortion (DPD) and RF power amplifier (PA) development platform with separate synchronous and coherent RF channels to evaluate multi-input RF PAs with realistic modulated test signals. The platform is based on a Xilinx FPGA and wideband analog frontends to support signal bandwidths up to 312.5 MHz. We describe both the implemented hardware as e.g. DPD core and d
Spotted phenotypes in horses lost attractiveness in the Middle Ages
Horses have been valued for their diversity of coat colour since prehistoric times; this is especially the case since their domestication in the Caspian steppe in ∼3,500 BC. Although we can assume that human preferences were not constant, we have only anecdotal information about how domestic horses were influenced by humans. Our results from genotype analyses show a significant increase in spotted
Advances in male reproductive surgery : robotic-assisted vasovasostomy
It is estimated that 3-6% of all vasectomised men request vasectomy reversal for different reasons. Microsurgical vasovasostomy is the gold standard technique of vasectomy reversal. However, the microsurgical technique is time-consuming and challenging to most urological surgeons. Therefore, alternative methods of vasal anastomosis have been studied including robotic-assisted vasovasostomy. This r
Testicular biopsy : clinical practice and interpretation
Testicular biopsy was considered the cornerstone of male infertility diagnosis for many years in men with unexplained infertility and azoospermia. Recent guidelines for male infertility have limited the indications for a diagnostic testicular biopsy to the confirmation of obstructive azoospermia in men with normal size testes and normal reproductive hormones. Nowadays, testicular biopsies are main
Cooperation facilitates the colonization of harsh environments
Animals living in harsh environments, where temperatures are hot and rainfall is unpredictable, are more likely to breed in cooperative groups. As a result, harsh environmental conditions have been accepted as a key factor explaining the evolution of cooperation. However, this is based on evidence that has not investigated the order of evolutionary events, so the inferred causality could be incorr
Fracture study of ferritic/martensitic steels using Weibull stress analysis at quasi-static and higher loading rates
Effect of loading rate on cleavage failure probability for ferritic/martensitic steels using Weibull stress analysis is studied. Calibration of Weibull slope for two grades of fusion reactor blanket steels namely, Indian Reduced Activation Ferritic/Martensitic Steel referred as In-RAFMS, F 82H and a non fusion grade modified 9Cr-1Mo steel (P91) are performed for the first time. The calibrated valu
Synthesis, Crystal Structures, Magnetic Properties, and Theoretical Investigation of a New Series of NiII-LnIII-WV Heterotrimetallics : Understanding the SMM Behavior of Mixed Polynuclear Complexes
The polynuclear compounds containing anisotropic metal ions often exhibit efficient barriers for blocking of magnetization at fairly arbitrary geometries. However, at variance with mononuclear complexes, which usually become single-molecule magnets (SMM) under the sole requirement of a highly axial crystal field at the metal ion, the factors influencing the SMM behavior in polynuclear complexes, e