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Superantigens from Staphylococcus aureus induce procoagulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1 beta

BACKGROUND: Staphylococcus aureus is one of the most common bacteria in human sepsis, a condition in which the activation of blood coagulation plays a critical pathophysiological role. During severe sepsis and septic shock microthrombi and multiorgan dysfunction are observed as a result of bacterial interference with the host defense and coagulation systems.OBJECTIVES: In the present study, staphy

Immunsvar och inflammation vid Crohns sjukdom. Snart möjligt driva diagnostiken längre och utveckla mer specifika läkemedel

The chronic inflammation in Crohn's disease may be caused by aggressive response to bacterial antigens normal to the gut. Genetic and environmental factors modify the inflammatory response evoked by damage to the mucosal gut barrier. Genetic factors may also determine the subsequent course of chronic inflammation. Further elucidation of the pathogenesis might improve our understanding of the heter

Computational Studies of Molybdenum and Tungsten Enzymes

We review computational studies of three important mono-nuclear molybdenum oxo-transfer enzymes, dimethylsulfoxide reductase, sulfite oxidase and xanthine oxidase. We show that calculated energies for these reactions are very sensitive to details in the calculations, in particular to the density-functional method employed and the size of the basis set, but the treatment of dispersion and solvation

Law and Digital Society

The article argues that the digitally mediated and data-driven development stresses the need for socio-legal scrutiny. It focuses and briefly outline socio-legally relevant aspects of the “sharing” economy, that poses a number of conceptual issues on how we understand and regulate innovative platform based ventures. The article also underscores a number of issues relating to the role of consumer aIn this article we argue the need for more socio-legal scrutiny in a digitally mediated and data-driven development. We focus and briefly outline socio-legally relevant aspects of the “sharing” economy, that poses a number of conceptual issues on how we understand and regulate innovative platform based ventures. This also arguably underscores a number of issues relating to the role of consumer and

Clock-gating of streaming applications for energy efficient implementations on FPGAs

The paper investigates the reduction of dynamic power for streaming applications yielded by asynchronous dataflow designs by using clock gating techniques. Streaming applications constitute a very broad class of computing algorithms in areas such as signal processing, digital media coding, cryptography, video analytics, network routing and packet processing and many others. The paper introduces a