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Glucocorticoid-induced osteoporosis may be at least in part due to the increased apoptosis of osteocytes. To study the role of osteocyte apoptosis in glucocorticoid-induced osteoporosis, we isolated primary osteocytes from murine calvaria for the analysis of the effects of dexamethasone in in vitro culture. The cells were identified by morphology, cytochemical staining, immunocytochemical staining
A laser diode structure realizing internal gain switching is suggested for high-power picosecond optical pulse generation. A thin wideband barrier layer is incorporated in the active region of this structure, in order to provide additional control of the carrier distribution and the gain dynamics. The dynamic laser output response to the nanosecond pumping current pulses is modeled and analyzed. T
Objective. To investigate whether sera or purified IgG from patients with polymyositis (PM) and patients with dermatomyositis (DM), with or without interstitial lung disease (ILD), can activate endothelial cells (ECs). Methods. Patients' sera were selected based on the presence or absence of anti-Jo-1, anti-SSA, or anti-U1 small nuclear RNP autoantibodies. The presence of autoantibodies was determ
We examine an effectively attractive quasi-one-dimensional Bose-Einstein condensate of atoms confined in a rotating toroidal trap, as the magnitude of the coupling constant and the rotational frequency are varied. Using both a variational mean-field approach, as well as a diagonalization technique, we identify the phase diagram between a uniform and a localized state and we describe the system in
Abstract Aim: The Redesigning Daily Occupations programme (ReDO) is a Swedish work rehabilitation programme for women on sick leave due to stress-related disorders. The aim of the study was to investigate the participants' perceptions of taking part in the work rehabilitation programme. Methods: Seven of the 38 women who completed ReDO were interviewed during and after the programme. The interview
A Monte Carlo model of an Elekta Precise linear accelerator has been built and verified by measured data for a 6 and 10 MV photon beam running with and without a flattening filter in the beam line. In this study the flattening filter was replaced with a 6 mm thick copper plate, provided by the linac vendor, in order to stabilize the beam. Several studies have shown that removal of the filter impro
Abstract in UndeterminedDataflow descriptions have been used ina wide range of Digital Signal Processing (DSP)applications, such as multi-media processing, andwireless communications. Among various forms ofdataflow modeling, Synchronous Dataflow (SDF) isgeared towards static scheduling of computationalmodules, which improves system performance andpredictability. However, many DSP applicationsdo no
This article explores how the 'liberal democratic peace package' is received in post-conflict spaces. As such, it is part of a critical peace research agenda that raises critical questions concerning the quality of peace in many post-conflict societies. A close reading of the peace-building process in post-conflict Kosovo provides the backdrop for the theoretical discussion that identifies frictio
Psychosocial stress at work is one of the most important factors behind increasing sick-leave rates. In addition to work stressors, it is important to account for non-work-related stressors when assessing stress responses. In this study, a modified version of the Stress-Energy Questionnaire (SEQ), the SEQ during leisure time (SEQ-LT) was introduced for assessing the affective stress response durin
Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of AML patients, but not on normal hematopoietic stem cell
Frequent hyperglycaemia is associated with oxidative stress and subclinical inflammation, and thus increased risk of cardiovascular disease. Possibilities of modulating glycaemia, insulinaemia and perceived satiety for bread products were investigated, with emphasis on the course of glycaemia expressed as a glycaemic profile (defined as the duration of the glucose curve above the fasting concentra
Serum amyloid A (SAA) is a multifunctional acute-phase protein whose natural role seems to be participation in many physiologic and pathological processes. Prolonged increased SAA level in a number of chronic inflammatory and neoplastic diseases gives rise to reactive systemic amyloid A amyloidosis, where the N-terminal 76-amino acid residue-long segment of SAA is deposited as amyloid fibrils. Rec
Synergies between large-scale environmental changes, such as climate change(1) and increased humic content (brownification)(2), will have a considerable impact on future aquatic ecosystems. On the basis of modelling, monitoring and experimental data, we demonstrate that community responses to global change are determined by food-chain length and that the top trophic level, and every second level b
In this paper we demonstrate that the Monte Carlo simulation package McStas is a useful tool, not only for instrument design, but also for resolution function calculation. It has been possible to determine analytically the 4 dimensional resolution function of both a direct geometry time of flight neutron spectrometer and a triple axis spectrometer. The obtained resolution functions are directly co
Introduction: Apolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrier protection. The aim was to determine the plasma concentrations of apoM during sepsis and systemic inflammatory response syndrome (SIRS) and correlate them to levels of apolipoprotein A-I (apoA1), apol
In this work, a two-dimensional computational fluid dynamics study is reported of an n-heptane combustion event and the associated soot formation process in a constant volume combustion chamber. The key interest here is to evaluate the sensitivity of the chemical kinetics and submodels of a semi-empirical soot model in predicting the associated events. Numerical computation is performed using an o
I propose a new index, the b-index, to measure the performance of funds and fund managers. A fund or fund manager has a b-index equal to b if b is the highest number for which it holds that the fund/fund manager has returned more than b% at least b years throughout the history of the fund/fund manager.
Background:To evaluate the relationships between postnatal change in circulatory insulin-like growth factor I (IGF-I) concentrations, brain volumes, and developmental outcome at 2 years of age in very preterm infants.Methods:IGF-I was measured weekly and nutritional intake was calculated daily from birth until a postmenstrual age (PMA) of 35 weeks. Individual beta coefficients for IGF-I, IGF-I(B)
