Although morphology-based phylogenetic analyses and molecular data suggested that the cycloneuralians might have emerged in the Ediacaran Period, the oldest known fossil remains of cycloneuralians were first reported from the Cambrian Fortunian Stage of South China, and to date four genera and species as well as nine indeterminate forms have been described. Here, we report the latest discoveries o

This article develops a method for simultaneous estimation of density functions for a collection of populations of protein backbone angle pairs using a data-driven, shared basis that is constructed by bivariate spline functions defined on a triangulation of the bivariate domain. The circular nature of angular data is taken into account by imposing appropriate smoothness constraints across boundari

Background: Survivors of myocardial infarction (MI) are at high risk of new major adverse cardiovascular events (MACE). Coronary flow reserve (CFR) is a strong and independent predictor of MACE. Understanding the prevalence of impaired CFR in this patient group and identifying risk markers for impaired CFR are important steps in the development of personalized and targeted treatment for high-risk

Aims: We aimed to discover and replicate associations between leisure-time physical activity and cardiovascular candidate plasma protein biomarkers and to examine whether the associations were independent of body fat. Methods: We used cross-sectional data from two population-based cohorts, the EpiHealth (discovery cohort; n = 2239) and the Swedish Mammography Cohort – Clinical (SMCC; replication c

Resistivity data constitute the largest part of the available information to assess the hydrogeological characteristics of the aquifer system near Oruro, in the central part of the Bolivian Altiplano. Two aquifers are part of this system; top unconsolidated sediments storing fresh water in their granular voids, overlying fractured hard rock formations where saline water was detected in connection

SummaryThe human pathogen Streptococcus pyogenes (GAS) causes both superficial infections, such as strep throat, and invasive infections, such as necrotizing fasciitis, and is responsible for about half a million deaths each year. The number of GAS infections have increased since the 1980’s, due to the emergence of a M1T1 strain that has become widely disseminated. Increased expression of Streptol

The sustainable use of groundwater relies on building up three stages: exploration, development and management. The exploration is crucial to understand the capabilities and limitations of aquifer units; e.g. volume of available water and potential yield, distinction of recharge and discharge zones, and the groundwater quality are developed in this stage. In the Altiplano, groundwater is probably

Two controlled experiments were operated to evaluate the impact of pH on the treatment efficiency of azo dyes within artificial textile wastewater using ponds as a polishing step. The objectives were to assess the (1) inflow water quality; (2) the presence of Lemna minor and the algae Oedogonium spp. on the dye removal and the outflow water quality; and (3) suitability of applying artificial texti

Peripheral artery disease (PAD) is caused by atherosclerosis and associated with an increased risk of leg amputation, cardiovascular disease, and death. A healthy diet has been shown to reduce the risk of cardiovascular events, but relationships between diet, fiber intake, and incidence of PAD are virtually unknown. The aim was to investigate the long-term impact of diet on the development of PAD

Background: The transcription factor signal transducer and activator of transcription 3 (STAT3) is implicated in cancer drug resistance, metastasis, and immunosuppression and has been identified as a promising therapeutic target for new anticancer drugs. Myeloid-derived suppressor cells (MDSCs) play a major role in the suppression of antitumor immunity and STAT3 is involved in the accumulation, ge

To investigate the relation between joint involvement in the upper extremities and grip force in patients with early rheumatoid arthritis (RA). An inception cohort of 225 patients with early RA was followed according to a structured protocol. The same rheumatologist assessed all patients for swollen joints and joint tenderness. Grip force was measured (Grippit; AB Detektor, Gothenburg, Sweden) at

The unknown role of the carrier protein transthyretin (TTR) in mechanisms of functional recovery in the postischemic brain prompted us to study its expression following experimental stroke. Male C57/B6 mice (age 9 to 10 weeks) were subjected to permanent focal ischemia induced by photothrombosis (PT) and brain tissues were analyzed for ttr expression and TTR levels at 24 hours, 48 hours, 7 days an

A new generation of N-heterocyclic carbene palladium(II) complexes containing vinyl groups in different positions in the backbone of the N-heterocycle have been developed. The fully characterised monomers were copolymerised with divinylbenzene to fabricate robust polymer supported NHC-PdII complexes and these polymers were applied as heterogeneous catalysts in directed C-H halogenation of arenes w

Epidemiological data indicate decreased risk for development and growth of abdominal aortic aneurysm (AAA) among patients with diabetes mellitus (DM). On the other hand, DM adds to increased cardiovascular (CV) morbidity and mortality. In a nationwide observational cohort study of patients registered in the Swedish Vascular Register and the Swedish National Diabetes Register, we evaluated potentia

Purpose: The purpose of this paper is to study the effects of dimple geometries and arrangements on the heat transfer enhancement in a dimple jacketed heat exchanger. Design/methodology/approach: For the purpose of this paper, with the experimental validated numerical model, this paper carries out numerical simulations of both single dimples with different geometries and the whole dimple jacketed

Vi tittar upp nattetid och ser att vår Jord har en måne kretsande runt sig. Denna kallar vi Månen, och den har vi utforskat med hjälp av rymdsonder, olika landare och med hjälp av Apollo-astronauterna. Andra planeter har också månar kretsande runtom sig. Månar som ser helt annorlunda ut än vad vår egen Måne, vissa är små och ser ut som asteroider medans andra är så isiga att de skulle kunna förvanAs we look up at night we see that our Earth has one moon orbiting it, the one we call the Moon. We have explored our moon with orbiters, rovers and astronauts, mapping it and studying its history.Other planets also have moons in orbit around them and these may look quite different from the Earth's moon. Some are small and look like asteroids, others are so icy they would become comets if they plu