Microorganisms play a crucial role in various physiological processes, including metabolism, immune defense, nutrition absorption, defense against cancer, and protection against pathogen colonization. Changes in microbial communities serve as potential biomarkers for diseases, offering significant insights into disease treatment and diagnosis. However, the association between microorganisms and di

Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug candidate. A limitation of the main structural method used today - conventional X-ray crystallography - is that it only provides structural infor

Although fathers experience emotional stress both during the care period and after discharge, there is limited research focusing exclusively on fathers’ experiences after their time in a neonatal intensive care unit. Their experiences are important for tailoring support to fathers based on their individual needs. This paper is part of a longitudinal study in which parents were followed by means of

Introduction Management of testicular torsion varies between specialties resulting in lack of standardization. The aim of this survey was to assess pre-, peri-, and postoperative differences. Methods An online questionnaire was distributed in 2023 to general and pediatric surgeons, pediatric urologists, and urologists by the Trainees of European Pediatric Surgery. Main Results Among 88 respondents

In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.

Background: The detrimental impacts of adverse childhood experiences (ACEs) on health have been extensively studied, mainly focusing on the effects of ACEs on adults. However, there is a dearth of studies exploring their influences on adolescents. Objective: This study aims to investigate the associations between ACEs and psychological distress among Swedish adolescents. Participants and setting:

Included in 'Peter Sheppard Skærved’s Knowledge Exchange Violin'. A project that brings together historic instruments, composers, nature , painting, ecologists, architecture, and much more.

We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with neuropathic pain were cases and compared with those exposed to injury or disease but without neuropathic pain as control subjects. Diabetic polyneuropathy was the most common aetiology of neuropathic pain. A standardised quantitative sensory testing protocol was used to categorize

Ground-level ozone (O3), formed via complex photochemistry involving nitrogen oxides (NOx) and volatile organic compounds (VOCs), is a critical secondary pollutant and oxidant. Therefore, understanding whether the formation of O3 is NOx- or VOC-limited is essential for effective air quality management. Recently, we demonstrated that the distribution of highly oxygenated organic molecules (HOMs) ca

This study delves into the landscape of health applications within online markets. These applications, offering health-related functionalities, have become integral to the lives of European citizens. The transformation of healthcare delivery, accelerated by the pace of modern life and accentuated by the COVID-19 pandemic, has elevated health applications from conveniences to essential tools capabl

While several rating scales reliably and cost-effectively assess behavioral executive functioning (EF) in youths with neurodevelopmental disorders (NDDs), questions remain about the impact of comorbidities and dual NDDs on EF as measured by these scales in clinical samples. This study compared behavioral EF profiles among youths with NDDs, both with and without psychiatric comorbidities, non-NDDs

How microglia digest Alzheimer's fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that primary microglial cells create acidic extracellular compartments, lysosomal synapses, on model plaques and digest them with exocytosed lysosomal enzymes. This mechanism, called digestive exophagy, is confirmed by electron microscopy in 5xFAD mouse b

Cesarean section (CS) is a life-saving procedure when performed for the right indication but carries substantial risks, specifically during subsequent pregnancies. The aim of this study was to evaluate obstetric outcomes for women 5 years after a CS performed by medical doctors and associate clinicians. This was a prospective multi-center observational study of women who had a CS at any of nine ho

This book arises from the shared interest in practices of writing of artists and scholars in the field of performance, dance, and visual arts. For all authors writing is - in various forms and to different ends - an essential part of their work: as a movement practice and a mode of self-reflection, an aesthetic and epistemic practice. The different approaches converge in the idea of an "expanded w

This thesis examines three plan b performance pieces, which are all based on a long-term practice of recording GPS data daily (15 years for me at time of writing). The works comprise different performative processes to materialise the data through public drawing, narrating and collective knotting. Each of the pieces is related to the respective central themes of movement, memory and time. Through

CysK1 and CysK2 are two members of the cysteine/S-sulfocysteine synthase family in Mycobacterium tuberculosis, responsible for the de novo biosynthesis of L-cysteine, which is subsequently used as a building block for mycothiol. This metabolite is the first line defense of this pathogen against reactive oxygen and nitrogen species released by host macrophages after phagocytosis. In a previous medi

The Bell-state measurement (BSM) is the projection of two qubits onto four orthogonal maximally entangled states. Here we first propose how to appropriately define more general BSMs, which have more than four possible outcomes, and then study whether they exist in quantum theory. We observe that nonprojective BSMs can be defined in a systematic way in terms of equiangular tight frames of maximally

Enzymes carrying NlpC/p60 domains, for instance RipA and RipB from Mycobacterium tuberculosis, are bacterial peptidoglycan hydrolases that cleave the peptide stems and contribute to cellwall remodelling during cell division.Amember of this protein family, RipD (Rv1566c) from M. tuberculosis described in the present study, displays sequence alterations in the NlpC/p60 catalytic triad and carries a

Purpose: To develop a deep learning-based algorithm that automatically and accurately classifies patients as either having pulmonary emboli or not in CT pulmonary angiography (CTPA) examinations. Materials and methods: For model development, 700 CTPA examinations from 652 patients performed at a single institution were used, of which 149 examinations contained 1497 PE traced by radiologists. The n

Quantitative flow ratio (QFR) represents a physiological index derived from angiography through three-dimensional (3D) quantitative coronary analysis. When compared to coronary angiography, QFR showed better performance both for guiding percutaneous coronary intervention (PCI) in case of intermediate coronary lesions and for optimising PCI results. In addition, QFR showed good diagnostic agreement