Understanding receptor activation is important for disease intervention. Activation of the receptor tyrosine kinase c-KIT is involved in numerous diseases including melanoma, mastocytosis, multiple myeloma and gastrointestinal stromal tumors. To better understand the regulation of activation, we studied the two c-KIT isoforms, c-KIT(-) and c-KIT(+) which differ by a tetrapeptide insert GNNK, locat

Background: Mastery refers to the degree to which people perceive that they can control factors that influence their life situation, and has been found important for people's quality of life and well-being. It is thus essential to be able to measure mastery in a valid and reliable way. Aim: This study aimed at using the Rasch measurement model to investigate the psychometric properties of a Swed

BACKGROUND: We previously reported that a single prostate-specific antigen (PSA) measured at ages 44-50 was highly predictive of subsequent prostate cancer diagnosis in an unscreened population. Here we report an additional 7 years of follow-up. This provides replication using an independent data set and allows estimates of the association between early PSA and subsequent advanced cancer (clinical

The aim of this article is to draw attention to the dangerous, indeed poisonous, nature of the current debates on immigration and multiculturalism in today’s ‘omniphobic’ Europe, plagued not only by a severe economic crisis, but also a more general normative crisis, a ‘crisis of values’ so to speak, which has been consistently overlooked or manipulated by politicians and academics alike, or reduce

Abstract Objective. To explore factors and circumstances contributing to prudent antibiotic prescribing for respiratory tract infections in primary care. Design. Two focus groups representing rural and urban areas. A semi-structured interview guide with open-ended questions and an editing analysis style was used. They were examined to identify meaning units that were sorted into categories in an i

We present comprehensive results on continuous atmospheric cluster and particle measurements in the size range similar to 1-42 nm within the European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) project. We focused on characterizing the spatial and temporal variation of new particle formation events and relevant particle formation parameters across Europe. Dif

Objective. To analyse patients' self-reported reasons for not adhering to physical activity referrals (PARs). Design and setting. Data on 1358 patients who did not adhere to PARs were collected at 38 primary health care (PHC) centres in Sweden. Intervention. PHC providers issued formal physical activity prescriptions for home-based activities or referrals for facility-based activities. Subjects. O

Diskrimineringsterminologi förekommer på olika rättsliga nivåer: i internationell rätt, i grundlag och i vanlig nationell lagstiftning. Innebörden och användningen av ”diskriminering” varierar en del mellan olika rättsliga kontexter. Samtidigt vore diskriminering inte föremål för rättslig reglering på någon nivå om det inte betraktades som moraliskt problematiskt. Det rättsliga och det moraliska h

Relationships among allotetraploid marsh orchids collectively assignable to Dactylorhiza majalis s.l. are exceptionally complex because of multiple origins, secondary hybridization with each other, and with their parental lineages, local adaptation, and genomic reorganization processes, all extending through time and space. We sampled 34 populations from Britain and Ireland in an attempt to simult

Let mu be a Gibbs measure of the doubling map T of the circle. For a mu-generic point x and a given sequence {r(n)} subset of R+, consider the intervals (T-n x - r(n) (mod 1), T-n x + r(n) (mod 1)). In analogy to the classical Dvoretzky covering of the circle, we study the covering properties of this sequence of intervals. This study is closely related to the local entropy function of the Gibbs me

Hemicelluloses isolated from agricultural residues have the potential to replace fossil-based materials in high-value-added applications, provided that cost-efficient isolation processes are developed. In this study, a feed solution containing hemicelluloses extracted from wheat bran with a particular high viscosity was used to study the performance of ultrafiltration for hemicellulose isolation a

Background: Assessing and evaluating health care is important, and an abundance of instruments are developed in different languages. Translating existing, validated instruments is demanding and calls for adherence to protocol. Purpose: The purpose of this study was to translate and culturally adapt the FAMCARE-2 scale for use in Sweden. Methods: Traditional back-translation and the decentering sta

A generic search for anomalous production of events with at least three charged leptons is presented. The search uses a pp-collision data sample at a center-of-mass energy of root s = 7 TeV corresponding to 4.6 fb(-1) of integrated luminosity collected in 2011 by the ATLAS detector at the CERN Large Hadron Collider. Events are required to contain at least two electrons or muons, while the third le

The aging of Western populations is expected to result in increasing occurrence of aortic stenosis (AS), but data are limited. Recent studies have reported declining incidence and mortality for other major heart diseases. We aimed to study temporal trends in the incidence and prognosis for AS in Sweden.

Mobility growth poses considerable challenges to city planners around the world, as it entails problems of congestion, air pollution, and accidents. Many cities have thus sought to increase the share of sustainable transport, and specifically travel by bicycle. However, it appears that measures to foster cycling are often implemented on an ad hoc basis, lacking strategic focus and a more profound

Triple negative (TN) breast cancers make up some 15% of all breast cancers. Approximately 10-15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required for homologous recombination-mediated DNA repair and deficiency results in genomic instability. BRCA1-mutated tumors have a specific pattern of genomic copy number aberrations that can be used to classify tumors as BRCA1-like or non-BRCA1-li

One third of patients with stage T1 urothelial carcinoma (UC) progress to muscle-invasive disease requiring radical surgery. Thus, reliable tools are needed for risk stratification of stage T1 UC.

Critical infrastructure systems must be both robust and resilient in order to ensure the functioning of society. To improve the performance of such systems, we often use risk and vulnerability analysis to find and address system weaknesses. A critical component of such analyses is the ability to accurately determine the negative consequences of various types of failures in the system. Numerous mat