Structural biology has transformed a number of fields of biochemistry and biology. A few examples are the following. The allosteric uptake and release of oxygen from haemoglobin obtained an elegant description from the work of Perutz [ Perutz ( 1970), Nature ( London), 227, 726 - 739; Perutz et al. ( 1998), Annu. Rev. Biophys. Biomol. Struct. 27, 1 - 34]. The structure of tRNA highlighted the fact

High-resolution capacitance measurements were used to explore the effects of the gut hormones GLP-I(7-36) amide [glucagon-like peptide I(7-36) amide] and GIP (glucose-dependent insulinotropic polypeptide) on Ca2+-dependent exocytosis in glucagon-secreting rat pancreatic alpha-cells. Both peptides produced a greater than threefold potentiation of secretion evoked by voltage-clamp depolarizations, a

Aim: To identify early predictors of outcome in infants born at 25 gestational weeks. Material and Methods: Data from a regional perinatal database (time-period 1995-2001, total n = 108 000 births) were used. Apgar scores were available in 92 preterm infants, born at 25 + 0 to 25 + 6 gestational weeks, and analyzed in relation to short-term outcome (180-day survival with, or without, severe brain

Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demo

This prospective observational data collection study assessed the cost and quality of life related to hip, vertebral and wrist fracture 1 year after the fracture, based on a patient sample consisting of 635 male and female patients surviving a year after fracture. Data regarding resource use and quality of life related to fractures was collected by questionnaires at baseline, 4 months and 12 month

Recently, the structure of protein ions in vacuo has received a lot of interest. Experimentally, such structures can only be characterized by global, low-resolution descriptors like the orientationally-averaged collision cross section (σ) over bar. An alternative descriptor of chain entanglement, the mean overcrossing number (N) over bar, is a very useful tool because it can distinguish sensitivel

Abstract in French Cette étude a été réalisée pour déterminer si les papillomatoses virales du col sont associées à l'utilisation des contraceptifs et aux antécédents de reproduction. Après avoir enregistré les antécédents de contraception et de reproduction de 972 femmes ayant demandé des conseils en matière de contraception, des examens ont été conduits pour dépister toute infection de papillomaThe study was conducted to investigate whether cervical human papillomavirus infections (CHPI) are associated with contraceptive use and reproductive history. The contraceptive and reproductive histories in 972 women seeking contraceptive advice were noted and screening conducted for human papillomavirus infection. The interview included number of pregnancies and childbirths, legal and spontaneous

Particle-gammagamma and gammagamma-coincidences of the reaction Ni-58(Ar-36, 4 pn)89Mo have been used to gain more information about high spin states in 89Mo and to establish the yrast sequence up to 7.6 MeV excitation energy and probable spin 37/2 h. Spins and parities were assigned on the basis of DCO-ratios measured with the OSIRIS spectrometer and a large volume Ge detector placed at 162-degre

The effect of different block lengths of Pluronic surfactants, (EO)(x)-(PO)(y)-(EO)(x), in the formation of mesoporous silica has been investigated. The syntheses were performed in micellar solution of the surfactant under acidic conditions. The materials were characterized by SAXS, TEM and nitrogen adsorption measurements. The EO-block length of the polymers determines the mesostructure of the si

Abstract is not available

In this study we compared plasma contents of long-chain polyunsaturated fatty acids (LC-PUFAs) and trans fatty acids in triglycerides (TG), phospholipids (PL) and cholesterolesters (CE) in young children fed milk diets containing different amounts of linoleic (LA) and alpha-linolenic acid (ALA). Because the diets differed in vitamin A and E content, plasma concentrations of vitamin A and E were al

Learning activities and course design in the new context of e-learning, such as in web-based courses involves a change both for teachers and students. The paper discusses factors important for e-learning to be successful. The development of an online course in medical physics and technology for high school teachers of physics, details of the course, and experience gained in connection with it are

A systematic review of radiation therapy trials in several turnout types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for head and neck cancer is based on data from 39 randomized trials and I

Preliminary results from the first experiment of the Stopped Beam RISING campaign are presented. The relativistic projectile fragmentation of a 750 MeV/u beam of Ag-107 populated isomeric states in very neutron deficient nuclei at the proton dripline around mass 80-90. Nuclei were unambiguously identified using the FRagment Separator (FRS) and its ancillary detectors located at GSI. The ions produ

Popular Abstract in Swedish Det finns samband mellan halten av små luftburna partiklar och negativa hälsoeffekter i befolkningen. Målsättningen med avhandlingen var att utveckla och utvärdera metoder för in-situ karakterisering av fina (< 1 um) och ultrafina (Fine airborne particles are associated with adverse health effects in the human population. The aim of this research was to develop and evaluate methods for in-situ characterisation of fine and ultrafine particles and to determine their deposition in the human airways. The aim was also to increase knowledge about health and environmentally relevant properties of aerosols from biomass combustion an