Poem framfört vid doktorspromotionen i Lund 24 maj 2019

Serine hydroxymethyltransferase (SHMT) is the major source of 1-carbon units required for nucleotide synthesis. Humans have cytosolic (SHMT1) and mitochondrial (SHMT2) isoforms, which are upregulated in numerous cancers, making the enzyme an attractive drug target. Here, we show that the antifolates lometrexol and pemetrexed are inhibitors of SHMT2 and solve the first SHMT2-antifolate structures.

Beslutsfattare bör inse betydelsen av butikers vara eller inte vara för samhällets utveckling innan det är för sent, skriver Karin M Ekström, professor i företagsekonomi, och Håkan Jönsson, docent i etnologi.

Occupational well-being is a central issue underpinning factors that constitute a good life. This study aimed to explore occupational well-being among Middle Eastern immigrants to Sweden, as reflected in the occupations performed in the context of psychosocial health care. Ten participants experiencing mental health issues, who received occupation-based rehabilitation, were interviewed. Grounded t

There is a scarcity of rehabilitation methods for people with stress-related disorders that are effective in terms of return to work and reducing sick leave. This chapter describes the Redesigning Daily Occupations (ReDOTM) program for women with stress-related disorders, the development, its main principles, and primary and secondary outcomes. The ReDOTM program, which addresses people’s whole re

Due to the great variation in approaches to psychiatric rehabilitation, the literature does not provide a uniform description of these methods. In this review, outcomes in terms of subjective quality of life are discussed in relation to vocational training, activity-based rehabilitation, case management, and social skills training. Relationships between aspects of daily life and subjective quality

Twenty patients, receiving group based psychiatric outpatient occupational therapy, were assessed at admission and discharge regarding psychiatric symptoms (SCL-90-R), global mental health (HSRS), quality of life (SQoL), and occupational performance (AOF). The patients were in treatment from 4 to 30 months. There were statistically significant improvements from admission to discharge on all variab

"Homo deus: a short history of the future", Yuval Noah Harari's book discusses the sources of power of modern man, beginning especially after the Second World War. The starting approach is the Enlightenment-specific, glorifying progress and then follow optimistic conclusions for the future. The impression is of progressive euphoria, but it is true that sometimes the jubilation is suspended and the

Background: People with psychiatric disabilities often struggle with maintaining a satisfying occupational balance. Knowledge about factors of relevance for occupational balance in this group is therefore vital for improving their support.Aim: The aim was to describe perceptions of occupational balance among people with psychiatric disabilities living in supported housing (SH) or in own flat/house

Research indicates that occupation is important for well-being in people with mental illness, but this has not been extensively studied among those with severe psychiatric disabilities. Social contacts may possibly play a more vital role for them. This study aimed to explore how aspects of occupation and social interaction were related with well-being factors in that group, while controlling for t

Objective: People who suffer from psychiatric illness have a more than doubled lifetime risk of acquiring an alcohol or drug use disorder. Furthermore, hazardous substance use impairs treatment outcomes and protracts the duration of illness among people with mental disorders. The aim of this study was to investigate substance use among people with psychiatric disabilities receiving municipality-ba

Satisfaction with everyday occupations has been shown to be important for health and well-being in various populations. Research into satisfaction with everyday occupations among elderly persons is, however, lacking. The aim was to investigate the psychometric properties of an adapted test version of the Satisfaction with Daily Occupations instrument (SDO) for elderly people, called SDO-E. Five ho

This case study investigates the implementation of a free-choice market system in community mental health services using the example of day centres for people with psychiatric disabilities. It was conducted in a major city that was about to implement a free-choice market system due to a new legislation that made it feasible. Eighteen semi-structured interviews were conducted. Agents situated in di

The aim of this study was to describe and analyse structural frames for choice, as well as characteristics of a free-choice market, implemented in community mental health services in Sweden. Day centres were focused. A case study was conducted. Documents were collected and semi-structured interviews were conducted with twenty-eight agents involved in the implementation process. Content analysis of

Background: Occupational therapists increasingly encounter clients from diverse cultural backgrounds and need to meet their professional obligation of delivering culturally competent practice. Yet the process of cultural competency is poorly understood in occupational therapy practice. There is a need for a clear understanding of the meaning and process of cultural competency as it is enacted in p

The value of a quality-adjusted life-year (QALY) and the value of a statistical injury (VSI) are important measures within health economics and transport economics. Several studies have, therefore, estimated people's willingness to pay (WTP) for these estimates, but most results show scale insensitivity. The 'original' chained approach (CA) is a method developed to mitigate this problem by combini

Spatially coupled turbo-like codes (SC-TCs) have been shown to have excellent decoding thresholds due to the threshold saturation effect. Furthermore, even for moderate block lengths, the simulation results demonstrate a very good bit error rate performance in the waterfall region. In this paper, we discuss the effect of spatial coupling on the performance of TCs in the finite block-length regime.