Genetic variations have a multitude of effects on proteins. A substantial number of variations affect protein–solvent interactions, either aggregation or solubility. Aggregation is often related to structural alterations, whereas solubilizable proteins in the solid phase can be made again soluble by dilution. Solubility is a central protein property and when reduced can lead to diseases. We develo

For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. A systematic search was carried out usi

Preterm birth has been associated with altered cardiac phenotype in adults. Our aim was to test the hypothesis that children surviving extremely preterm birth have important structural or functional changes of the right heart or pulmonary circulation. We also examined relations between birth size, gestational age, neonatal diagnoses of bronchopulmonary dysplasia (BPD) and patent ductus arteriosus

A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the quest

Red blood cell (RBC) shape change under static and dynamic shear stress has been a source of interest for at least 50 years. High-speed time-lapse microscopy was used to observe the rate of deformation and relaxation when RBCs are subjected to periodic shear stress and deformation forces as they pass through an obstacle. We show that red blood cells are reversibly de-formed and take on characteris

Prior literature in the field of corporate social responsibility (CSR) has largely focused on investigating its relationship with organizational-related outcomes, whereas the impact of CSR on consumer behavior is largely ignored in the recent literature. Further, most of the prior studies have investigated CSR with a philanthropic viewpoint, but its importance in achieving marketing-related outcom

Collaborative governance approaches have been suggested as strategies to handle wicked environmental problems. Evaluations have found promising examples of effective natural resource governance, but also highlighted the importance of social-ecological context and institutional design. The aim of this study was to identify factors that contribute to the achievement of social and ecological sustaina

Acoustic response from lithics knapped by humans has been demonstrated to facilitate effective detection of submerged Stone Age sites exposed on the seafloor or embedded within its sediments. This phenomenon has recently enabled the non-invasive detection of several hitherto unknown submerged Stone Age sites, as well as the registration of acoustic responses from already known localities. Investig

The constituents of dark matter are still unknown, and the viable possibilities span a vast range of masses. The physics community has established searching for sub-GeV dark matter as a high priority and identified accelerator-based experiments as an essential facet of this search strategy. A key goal of the accelerator-based dark matter program is testing the broad idea of thermally produced sub-

In this explorative workshop I introduce the concept of co-costuming by inviting the participant to wear, explore and reflect on the bodily effects of costumes that connects two wearers. As researcher, I ask the participants to confront the ethically dimensions of the co-costumed experience (costumes that I produced and impose on wearers) that potentially is quite playful and, at the same time, bo

The zooarchaeological record of Iron Age Scania in south Sweden is rich and multi-faceted; within it are many clues to past human-animal relations. This book focusses on the management of cattle, sheep, pig and horse, and Scania, withits environmentally diverse composition, make up the study region for this topic, in which the author tries to give old bones new life by putting them in an archaeolo

I am not convinced that the challenge for self-adaptive software is how to handle unexpected changes. I believe that the real challenge is how to characterise the uncertainty that the self-adaptive software has to handle. Once a proper characterisation of the uncertainty is in place, I think handling unanticipated changes and situations becomes a lot simpler. What is difficult is to know what rang

Most off-the-shelf embedded control systems lack proper mechanisms to handle computational overload conditions. Therefore, delays may accumulate and produce overruns, potentially harming the stability and performance of the controlled system. In this paper, we explore a controller implementation in which overrun events are tolerated and tackled with a proper countermeasure, which can be easily plu

This paper focuses on the computation of the joint spectral radius (JSR), when the involved matrices are sparse. We provide a sparse variant of the procedure proposed by Parrilo and Jadbabaie to compute upper bounds of the JSR by means of sum-of-squares (SOS) programming. Our resulting iterative algorithm, called SparseJSR, is based on the term sparsity SOS (TSSOS) framework developed by Wang, Mag

OBJECTIVES: To define the clinical spectrum time-course and prognosis of non-Asian patients positive for anti-MDA5 antibodies.METHODS: We conducted a multicentre, international, retrospective cohort study.RESULTS: 149 anti-MDA5 positive patients (median onset age 53 years, median disease duration 18 months), mainly females (100, 67%), were included. Dermatomyositis (64, 43%) and amyopathic dermato

The European Spallation Source, currently under construction in Lund, Sweden, will be the world's most powerful neutron source. It is driven by a proton linac with a current of 62.5 mA, 2.86 ms long pulses at 14 Hz. The final section of its normal-conducting front-end consists of a 39 m long drift tube linac (DTL) divided into five tanks, designed to accelerate the proton beam from 3.6 MeV to 90 M

The nature of quadrupole and octupole collectivity in Rn222 was investigated by determining the electric-quadrupole (E2) and octupole (E3) matrix elements using subbarrier, multistep Coulomb excitation. The radioactive Rn222 beam, accelerated to 4.23 MeV/u, was provided by the HIE-ISOLDE facility at CERN. Data were collected in the Miniball γ-ray spectrometer following the bombardment of two targe

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat,

Background: Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing.Purpose: To validate a widely available non-contrast-enhanced MRI method for quantification of renal cortical and medullary volumes in pigs; investigate observer v

The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, f