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Plant membrane steroid binding proteins (MSBPs) belong to the membrane-associated progesterone receptors (MAPRs), which is present in all eukaryotic kingdoms. Plant MSBPs have been shown to regulate the function of cytochrome P450 enzymes, bind different steroidal compounds and confer salt tolerance. However, the exact molecular function of plant MSBPs remains elusive. Here, we perform a phylogene
Hemoglobin (Hb) can produce reactive oxygen species, including superoxide anions, which are intrinsically toxic. Superoxide dismutase (SOD) is present in red blood cells (RBCs) and provides important protection against such oxidative stress. Upon hemolysis, Hb becomes released from the RBCs and the normal protection systems involving SOD and catalase become very inefficient. In these instance
Medical waste management has been receiving increasing attention in recent years. The National Health Service (NHS) of the United Kingdom has started planning its waste strategy to comply with its Net Zero Goals. Waste management does not only involve waste disposal; the process includes segregation, collection, storage, and the transportation of waste from one point to another. Unusual characteri
The glymphatic system facilitates cerebrospinal fluid (CSF)-interstitial fluid exchange and plays a key role in solute clearance and neurophysiological homeostasis. While dysfunction of this system has been shown in traumatic brain injury, stroke, meningitis, idiopathic normal pressure hydrocephalus and neurodegenerative diseases, direct measurement of glymphatic transport in humans remains elusiv
BACKGROUND AND OBJECTIVE: Achieving adequate concentrations of beta-lactam antibiotics in patients with severe infections is challenging, and therefore therapeutic drug monitoring (TDM) would be optimal for guiding beta-lactam dosing, but is often limited by availability. UV/VIS spectrophotometry can quantify drug levels in saline, and if those levels truly reflect plasma concentrations, it could
The HLD-NAC (Hydrophilic-Lipophilic Difference - Net Average Curvature) equation of state is a powerful semi-empirical framework used to predict the phase behavior, solubilization, and interfacial properties of surfactant-oil-water (SOW) systems it is based on the assumption of a normalized curvature for an idealized microemulsion, represented as the coexistence of two fictitious phases: water dro
Konstnärlig forskning är ofta måltavla när välmenande röster vill värna konstens frihet. De artiklar om konstnärlig forskning som Kvartal publicerat av Jesper Andersson och Bogdan Szyber utgår dock från en förenklad och ofullständig bild av läget.
BACKGROUND AND PURPOSE: Pain as a long-term outcome following rectal cancer treatment has received limited attention in previous studies. This prospective cohort study examined pain prevalence up to 5 years post-surgery in patients treated with curative intent. Secondary aims included evaluating pain intensity and its interference with daily life, and comparing pain experiences with a reference po
We revisit the discussion on family limitation through stopping and spacing behavior both prior to and during the fertility transition. Using the birth histories of 13 519 settler women in nineteenth century South Africa we find no evidence of parity specific spacing prior to the transition. In addition we find no differences in spacing behavior based on differences in time invariant economic and
Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial wall. CD4+ T cells, some of which recognize peptide components of LDL as antigen, are recruited to the forming lesion, resulting in T-cell activation. Although these T cells are thought to be proatherogenic, LDL immunizat
Background: Chronic pain is a highly prevalent disease, leading to high health care costs, impaired productivity, and decreased quality of life. An artificial intelligence (AI)-powered, digital tool for self-management (PaindrainerTM) has been shown to be an effective treatment in chronic pain and may have potential to reduce the burden on costs and quality of life.Objective: The objective of thisBackgroundChronic pain is a highly prevalent disease, leading to high health care costs, impaired productivity, and decreased quality of life. An artificial intelligence (AI)-powered, digital tool for self-management (PaindrainerTM) has been shown to be an effective treatment in chronic pain and may have potential to reduce the burden on costs and quality of life.ObjectiveThe objective of this stu
While tau pathology is closely associated with neurodegeneration in Alzheimer's disease (AD), our prior work using multi-modality imaging revealed that mismatch between tau (T) and neurodegeneration (N) may reflect contributions from non-AD processes. The medial temporal lobe (MTL), an early site of AD pathology, is also a common target of co-pathologies such as limbic-predominant age-related TDP-
We describe the design and clinical utility of a digital tool aimed to increase the quality of life for chronic pain patients. PainDrainer™ is a drug-free, self-management tool, powered by artificial intelligence that adapts to the self-reported activities of each individual patient, resulting in a truly patient-centric support. The tool was tested in an open label, one-arm pilot study performed i
This chapter examines the integration of living materials into architectural design, focusing on the use of mycelium composites formed through fungal biotransformation. As architecture faces increasing demands for environmental responsibility, material innovation has turned toward biological systems capable of replacing high-impact construction materials. Mycelium, the filamentous body of fungi, o
Waste sorting is a cognitively demanding task with high environmental stakes. To support research on the categorisation and decision processes underlying waste sorting behaviour, this paper introduces an evaluated stimulus set of 790 images of naturally occurring waste items. The images were sampled from Danish and Swedish household waste, visually standardised, and evaluated by 526 Swedish partic
