Combined quantum chemical and molecular mechanics geometry optimisations have been performed on myoglobin without or with O(2) or CO bound to the haem group. The results show that the distal histidine residue is protonated on the N(varepsilon2) atom and forms a hydrogen bond to the haem ligand both in the O(2) and the CO complexes. We have also re-refined the crystal structure of CO-myoglobin by a

Calculating single-particle (Nilsson) levels in axially symmetric quadrupole-deformed potentials in coordinate space, the structure of weakly bound neutron orbits is studied in the absence of pair correlation. It is shown that in the wave functions of Omega(pi)=1/2(+) orbits, where Omega expresses the projection of the particle angular momentum along the symmetry axis, the l=0 (s(1/2)) component b

Since the cloning in 1990 of cDNA corresponding to mRNA transcribed at the blood group ABO locus, polymorphisms at the ABO locus and phenotype-genotype correlation have been analysed by several investigators. An enhancer-active minisatellite motif reported to contain four 43-bp repeats has been analysed by PCR in blood samples from 160 random Swedish blood donors. Different sizes of the DNA fragme

In light of the increased interest in small scale dosimetry, this paper presents a quantitative autoradiographic method for evaluation of heterogeneous activity distribution in tissues. This was studied in rat tissues after administration of 111In-chloride, -oxine, -tropolone, 111In-labeled homologous blood cells and 111In-anti-CEA-F(ab')2, using quantitative whole-body autoradiography. Quantifica

Lightweight walls are often designed as frameworks of studs with plates on each side-a double-plate structure. The studs constitute boundaries for the cavities, thereby both affecting the sound transmission directly by short-circuiting the plates, and indirectly by disturbing the sound field between the plates. The paper presents a deterministic prediction model for airborne sound insulation inclu

This thesis deals with the carbon balance in a subarctic landscape at different temporal and spatial scales. Its focus is mainly on the peatland and mountain birch forest (Betula pubescens ssp. czerepanovii) ecosystems within the Abisko area in northernmost Sweden. This is an area with a temperature close to the 0 OC mean annual isotherm. The area has during the last 30 years experienced a limited

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The atmospheric transport of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) was compared by measuring concentrations in air and deposition on an island located in the central basin of the Baltic Sea. Median SigmaPBDE and SigmaPCB concentrations (gaseous + particle) were 8.6 and 7.4 pg m(-3), respectively. Airborne PCBs were mainly found in the gaseous phase, while most

Goodpasture disease (GP) is defined by the presence of anti-glomerular basement membrane (anti-GBM) antibodies and rapidly progressive glomerulonephritis. Besides anti-GBM, many patients with GP produce anti-neutrophil cytoplasmic antibodies (ANCA). For elucidation of the pathophysiologic significance of ANCA in this setting, epitope and antigen specificity of the anti-GBM antibodies and antigen s

Popular Abstract in Swedish För att vi människor ska kunna upprätthålla balansen och utföra rörelser behöver vi ett komplext styrsystem som kontinuerligt kontrollerar och samordnar kroppens rörelser. Detta styrsystem, som kallas postural kontroll, får sin information från synen, balanssinnet (vestibularisorganen), led-muskelsinnet (proprioception) och receptorer i huden (mekanoreceptorer). Om någoThe ability to obtain correct balance control information and adjust motor performance appropriately are essential elements in effective postural control. However, functional disorders may affect the reliability of receptor information and ability to carry out corrective motions needed to maintain balance. This emphasizes the importance of rapid and accurate adaptation processes that can optimize

PURPOSE: A previous study has shown age- and sex-related differences in abdominal aortic compliance. In that study blood pressure determined by auscultation in the brachial artery was assumed to be equal to blood pressure in the abdominal aorta. To validate our findings we investigated the pressure-diameter (P-D) relationship of the abdominal aorta. METHODS: Diameter and pulsatile diameter change

A flow injection cell-based biosensor was constructed for 2,4-dichlorophenol (DCP) analysis by using a Clark-type oxygen electrode as a transducer. A mixed bacterial culture capable to biodegrade DCP was immobilized between a Teflon membrane and a dialysis membrane and attached to the oxygen electrode. Optimization of the flow rate, the injection volume, the carrier buffer concentration, and pH wa