Colorectal cancer (CRC), one of the most frequent neoplasias worldwide, has both genetic and environmental causes. As yet, however, gene-environment (G x E) interactions in CRC have been studied mostly for a small number of candidate genes only. Therefore, we investigated the possible interaction, in CRC etiology, between single-nucleotide polymorphisms (SNPs) on the one hand, and overweight, smok

New strategies are needed for breast cancer treatment and one initial step is to test new chemotherapeutic drugs in breast cancer cell lines, to choose candidates for further studies towards clinical use.

The ATLAS detector is used to search for high-mass states, such as heavy charged gauge bosons (W'. W*), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 36 pb(-1). No excess beyond standard model expectations is observed. A W' with sequential

The standard view of neural signaling is that a neuron can influence its target cell by exciting or inhibiting it. Learning is thought to involve strengthening or weakening synaptic connections. For most behaviors, the brain must learn to produce precisely timed activity patterns. Learned response timing is indispensable for a wide range of tasks and requires learning of interstimulus intervals (I

Popular Abstract in Swedish Den arbetsrehabilitering som traditionellt erbjuds personer med psykisk funktionsnedsättning kan beskrivas som en trappa där varje steg består av olika åtgärder för att öka personernas arbetsförmåga. Målet är att personerna successivt skall bli friskare, öka sin funktionsnivå och utveckla fler färdigheter innan de kan ta steget ut till ett konkurrensutsatt arbete. För pIn the light of the limited research on the subject of Individual Placement and Support (IPS) in a Swedish context, this thesis has contributed with knowledge of the effectiveness and experiences of IPS among persons with severe mental illness (SMI) living in Sweden. The thesis has also provided information about the work motivation among those persons with SMI who seek vocational support by IPS.

Aims: We sought to develop descriptions of health states associated with daytime and nocturnal hypoglycemia in a structured fashion from the patient's perspective under different combinations of severity and frequency of hypoglycemic events. Methods: An expert meeting followed by two patient focus groups was used to develop comprehensive descriptions of acute consequences of severe and non-severe,

This article deals with Sweden’s relations to the German cultural sphere in the early post-war era. Since the nineteenth century, Germany had been the main inspiration to Sweden, but the Second World War irrevocably ended this epoch in Swedish history. In the wake of the war the German legacy was critically examined. On the literary scene, critics generally paid a warm tribute to Thomas Mann and t

Antologin Etiska perspektiv inom arkeologin innehåller fjorton kapitel där studenter och lärare i Lund reflekterar över ämnesetiska frågor. Boken är ett resultat av etikkurser som har getts inom arkeologiutbildningen. Dessa kurser har visat sig få stor betydelse både för de studenter som gick på kurserna och för de studenter som idag på andra sätt får etiska perspektiv inom sin utbildning. För lär

The species richness of flower-visiting insects has declined in past decades, raising concerns that the ecosystem service they provide by pollinating crops and wild plants is threatened. The relative commonness of different species with shared ecological traits can play a pervasive role in determining ecosystem functioning, but information on changes in abundances of pollinators over time is lacki

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Investigations of heterozygosity-fitness correlations (HFCs) are central to the understanding how genetic diversity is maintained in natural populations. Advanced genome-wide approaches will enrich the number of functional loci to be tested. We argue that a combined analysis of the genetic mechanisms of HFCs and selection signals at single loci will allow researchers to better understand the micro

Biografi över prinsessan Sophia Albertina, Gustaf III:s syster.

Background/aim - There are several reports that claim anticipation in complex or polygenic diseases such as multiple sclerosis (MS), Crohn disease or schizophrenia. The aim of the present study was to assess age at onset of MS during the last 60 years in the region of Costa de Ponent (Barcelona, Spain) showing how apparent changes in age at onset between generations can be an artefact of analysis

The influence on the short-range packing in dipolar fluids by molecular shape and by additional higher order electrostatic moments has been investigated by molecular dynamic simulations. The dipole polarization was found to decrease as the particles were elongated parallel to the dipole and to increase for elongation perpendicular to the dipole, eventually forming a nematic order. The addition of

Many HIV-2 and SIV isolates, as well as some HIV-1 strains, can use the orphan 7-transmembrane receptor GPR15 as co-receptor for efficient entry into host cells. GPR15 is expressed on central memory and effector memory CD4(+) T cells in healthy individuals and a subset of these cells is susceptible to HIV-1 and SIV infection. However, it has not been determined whether GPR15 expression is altered

There is currently substantial effort being invested into creating efficient thermoelectric (TE) nanowires based on topological insulator (TI) chalcogenide-type materials. A key premise of these efforts is the assumption that the generally good TE properties that these materials exhibit in bulk form will translate into similarly good or even better TE performance of the same materials in nanowire