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Background: The optimal timing of pharmacological treatment for patent ductus arteriosus (PDA) in extremely pre-term infants is unknown. Objective: To investigate whether timing of pharmacological PDA treatment is associated with a risk of secondary PDA surgery or death before 3 months of age, or bronchopulmonary dysplasia (BPD) in extremely preterm infants. Methods: In this population-based cohor
OBJECTIVES: The Rivermead Mobility Index (RMI) is widely used in several neurological conditions including multiple sclerosis (MS), but its psychometric properties have not been documented in Scandinavia. Therefore, the aim of the study was to translate RMI from UK English into Danish and conduct an initial psychometric testing of the Danish RMI. MATERIALS AND METHODS: The Danish translation condu
The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lympho
The increasing number of new psychoactive substances made available for recreational drug use has created a challenge for clinical toxicology and drug testing laboratories. As a consequence, the routine immunoassay drug testing may become less effective due to an increased occurrence of false negative and false positive screening results. This work aimed to extend the knowledge about analytical cr
In this paper we direct our attention to the problem of discretization effects in intensity transformations of images. We propose to use the Wasserstein metric (also known as the Earth mover distance) to bootstrap the transformation process. The Wasserstein metric gives a mapping between gray levels that we use to direct our image mapping. In order to spatially regularize the image mapping we appl
In Safeguards work under the Non-Proliferation Treaty, the isotopic analysis of uranium and plutonium micro particles has strengthened the means for detecting undeclared nuclear activities. In order to assure accuracy and precision in the analytical methodologies used, the instrumental techniques need to be calibrated. The objective of this study was to produce and characterize particles consistin
Palaeomagnetic analysis of the Lakhna Dykes (Bastar Craton, India) yields a palaeopole at 36.6 degrees N, 132.8 degrees E, dp=12.4 degrees, dm=15.9 degrees, and the U-Pb zircon age obtained from one of the rhyolitic dykes is 1466.4 +/- 2.6 Ma (MSWD = 0.21, concordia age based on two analyses with identical Pb/U ages), similar to previously published U-Pb ages. Major and trace element analyses of t
We consider time-dependent thermal fluid structure interaction. The respective models are the compressible Navier–Stokes equations and the nonlinear heat equation. A partitioned coupling approach via a Dirichlet–Neumann method and a fixed point iteration is employed. As a reference solver, a previously developed efficient time-adaptive higher-order time integration scheme is used. To improve on t
Nowadays, the same piece of code should run on different architectures, providing performance guarantees in a variety of environments and situations. To this end, designers often integrate existing systems with ad-hoc adaptive strategies able to tune specific parameters that impact performance or energy—for example, frequency scaling. However, these strategies interfere with one another and unpred
We studied the effect in children of an exercise intervention program on fracture rates and skeletal traits. Fractures were registered for 5 years in a population-based prospective controlled exercise intervention study that included children aged 6-9 years at study start, 446 boys and 362 girls in the intervention group and 807 boys and 780 girls in the control group. Intervention subjects receiv
Only a minority of patients treated with antipsychotics in clinical studies continue their treatments throughout a longer study period. Few studies address this issue from a lifetime perspective. In this naturalistic study, we aimed at analysing the prescription pattern of antipsychotic drugs among a sample of Swedish patients with a diagnosis of psychotic illness, from the first contact with psyc
A strongly coupled dipolar fluid confined in a sphere has been examined by Monte Carlo simulations using a modified distance-dependent pair interaction to emulate retardation effects. The effective dipole-dipole interaction and a property closely related to Kirkwood's g-factor have been analyzed for potentials with different distances at which the retardation effects became effective. The retardat
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data whi
Complex hydrides are very promising candidates for future light-weight solid state hydrogen storage materials. The present work illustrates detailed characterization of such novel hydride materials on different size scales by the use of synchrotron radiation and neutrons. The comprehensive analysis of such data leads to a deep understanding of the ongoing processes and mechanisms. The reaction pat
Secretion from many endocrine cells is a result of calcium-regulated exocytosis due to Ca(2+) influx. Using the patch-clamp technique, voltage pulses can be applied to the cells to open Ca(2+) channels, resulting in a measurable Ca(2+) current, and evoke exocytosis, which can be seen as an increase in membrane capacitance. A common tool for evaluating the relation between Ca(2+) influx and exocyto
Approximately 50% of children born with cleft palate present speech difficulties around 3 years of age, and several studies report on persisting phonological problems after palatal closure. However, studies on early phonology related to cleft palate are few and have so far mainly been carried out on English-speaking children. Studies on phonology related to cleft palate in languages other than Eng
