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In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal antibodies—a deeper understanding of how inflammatory a

The lung may be the organ whose mechanical environment needs to be most finely tuned to achieve optimal function. These needs have to be fulfilled at multiple scales, from proper force transmission between the chest wall and the parenchyma to reduction of surface tension by surfactants inside the alveoli. In addition, a plethora of mechanical loads and forces takes place within the lung, from the

Mobile Stroke Units (MSUs), which are specialised ambulances equipped with brain imaging devices and trained medical personnel, offer the potential for rapid on-site diagnosis and treatment, improving patient outcomes in prehospital stroke care. To fully realise their benefits, it is essential to strategically allocate. However, identifying optimal locations within a region for MSU deployment is t

Begreppet landsbygd används ofta som om dess innebörd vore självklar. I statistik, politik och samhällsdebatt beskrivs landsbygden ofta som motsatsen till staden: gles, avlägsen och präglad av jordbruk och natur. Denna rapport visar dock att landsbygden inte är ett enkelt eller entydigt fenomen. Tvärtom är landsbygd – eller ruralitet – ett komplext, föränderligt och relationellt begrepp som formas

Hur vi tar oss fram i vardagen påverkar inte bara vår egen livskvalitet, utan också klimatet, ekonomin och hur våra samhällen utvecklas. I Skåne, där både storstadsområden och gles landsbygd samsas i samma region, är mobilitet en särskilt viktig fråga. Den här rapporten undersöker vad ett stort antal regionala dokument säger om framtidens transporter med fokus på landsbygden.Ett av de tydligaste r

När vi pratar om mobilitet tänker många på bussar, tåg och bilar. Men på landsbygden handlar mobilitet om något större: tillgång till livet. Dagens sätt att mäta transporter är utformat för städer och fokuserar på kostnad per passagerare och restid. Dessa mått fungerar dåligt i glesbygd, där avstånd inte är ett val utan en geografisk realitet. Människor kör bil ofta för att det helt enkelt saknas

In everyday listening, speech perception occurs under conditions where acoustic information may be incomplete or ambiguous, including background noise and variability in signal quality. Listeners must navigate ambiguous, masked or rapidly unfolding speech signal in order to comprehend spoken language. While prediction has been widely discussed and acknowledged in speech perception, less is known a

BACKGROUND: – The arrhythmogenic right ventricular cardiomyopathy (ARVC) risk calculator estimates the risk of incident sustained ventricular arrhythmia (VA) and performs well in ARVC populations meeting 2010 Task Force Criteria. However, the calculator includes no measure of left ventricular (LV) structure and function, while late gadolinium enhancement (LGE) on cardiac magnetic resonance shows p

Den här rapporten undersöker hur Sölvesborgs kommun kan stärka hållbar mobilitet och samtidigt använda centrala ytor mer effektivt genom att etablera mobilitetshubbar. En mobilitetshubb kan beskrivas som en samlad nod där flera färdmedel och tjänster möts: cykelparkering, laddning, bilpool, lånecyklar, information, bokning och möjligheter att byta mellan gång, cykel, buss och tåg. I stället för at

Understanding water interactions in complex systems is crucial, as they play a key role in fields such as biochemistry, pharmaceutical formulations, and food science. Nuclear magnetic resonance (NMR) relaxation measurements have become one of the widely used methods to visualize various water characteristics owing to their noninvasive nature and ease of use. However, unambiguous data interpretatio

Understanding the atomic-scale interfaces in advanced semiconductor heterostructures is essential for controlling defects, optimizing material properties, and ensuring device reliability. In this work, we present a comprehensive study of the atomic structure at Al(Ga)N interfaces in N-polar GaN high-electron-mobility transistor structures (HEMTs) via aberration-corrected annular dark field scannin

Cambodia’s opening of Techo International Airport and the consolidation of the Bakong digital payment system signal a shift towards a more state-led and financially sophisticated development model. These initiatives reflect the Cambodian state’s expanding role in planning, financing and governing large-scale infrastructure and digital systems, deepening direct participation in development. While d

Epithelial-to-mesenchymal transition (EMT), driven by cues from the tumor microenvironment, is a critical initiator of metastatic progression. In breast cancer patients, elevated expression of cartilage oligomeric matrix protein (COMP) is associated with shorter survival and increased metastatic risk. Here, we investigated the role of COMP in regulating EMT in breast cancer. Breast cancer cells tr

Introduction: Traumatic axonal injury (TAI), often caused by rapid rotational forces and high-energy accidents, is common in severe traumatic brain injury (sTBI). The intracranial pressure (ICP) dynamics are often unpredictable, and the need for ICP monitoring remains debated. Research question: What is the incidence of ICP elevation in patients with TAI, and how often is escalated ICP-lowering tr

Mercury (Hg) has been stored in permafrost peatlands for millennia. As permafrost thaw is predicted to increase with ongoing climate warming, Hg is at risk to be remobilized from those peatlands and hotspots for Hg methylation could potentially form. Monomethylmercury (MeHg) is a known neurotoxin and a health concern to northern communities if Hg is remobilized, transformed to MeHg and subsequentl

Introduction: Shea butter is a kernel derived fat which includes several classes of compounds including lipids like tri- and diacylglycerols as well as unsaponifiable components. Background: Accurate determination of the compound class composition of shea butter is important for industry to quantify the levels of wanted compounds. Size exclusion chromatography (SEC) coupled with refractive index

Biogas är ett förnybart bränsle som tillverkas genom att organiskt avfall bryts ner utan syre. På St1 Biokrafts anläggning i Södertörn används avfall som matrester, gödsel och slakteriavfall för att producera biogas och biogödsel. Innan det organiska materialet förvandlas till biogas genom rötning kan avfallet förbehandlas för att påskynda processen och för att producera en rötrest som kan användaBiogas production plays an important role in the transition toward renewable energy systems by converting organic waste into methane and nutrient-rich biofertilizer. This study developed two process models to describe and predict the behaviour of the pre-treatment facility at St1 Biokraft’s biogas plant in Södertörn, Sweden. An annual model was constructed to reproduce the mass balance of input ma

Ett nytt aktivt kol har framställts från restprodukter inom pappersindustrin. Men är det tillräckligt effektivt för att motverka spridningen av PFAS? PFAS är en grupp skadliga kemikalier som utvecklades under förra århundradet och som fortfarande sprids i miljön, där de blir allt vanligare. Spridningen motverkas idag på flera sätt: genom förbud, genom att alternativa kemikalier tas fram och genom This study evaluated the performance of a new lignin-based activated carbon (AC) for the removal of per- and polyfluoroalkyl substances (PFAS) from contaminated groundwater from Korsør, Denmark. Preliminary tests using 14C-labeled PFOA and scintillation counting were conducted to compare adsorption capacities of three lignin-based AC variants and a commercial AC (Norit BAE Super), guiding the sele

Spider silk is a highly attractive biomaterial with exceptional strength and versatility, offering potential applications across numerous industries. However, large-scale production remains a significant challenge. Harvesting silk directly from spiders has proven impractical, making recombinant protein production a promising alternative. Spider silk has been studied at Lund University for several