Adrenomedullin is a potent vasodilatory peptide, linked to pulmonary arterial hypertension pathology. Proximity extension assays were utilized to study plasma biomarkers related to vasoregulation, with focus on adrenomedullin peptides and precursor levels, collectively referred to as ADM. ADM was measured in 48 treatment-naïve pulmonary arterial hypertension patients at diagnosis, and in 31 of the

It is widely accepted that climate change may be contributing to population movement and has gendered effects. The relationship between climate change as a direct cause of migration continues to give rise to debates concerning vulnerabilities, while at the same time gendered dimensions of vulnerabilities remain limited to binary approaches. There is limited cross-fertilization between disciplines

Background: The role of CT scanning at the time of diagnosis for patients with primary cutaneous head and neck melanoma (cHNM) clinically asymptomatic for metastatic disease remains unclear. Aim: To determine the positive yield of initial CT scanning before considering sentinel lymph node biopsy (SLNB) staging. Materials and methods: A retrospective review was performed on 170 consecutive patients

Home care for elderly people is an important part of the social welfare system. The sector employs many people, especially women, and work environment issues are common. This review explores the scientific literature on organizational interventions that target the home care work environment. Altogether, 16 studies of varying quality met the inclusion criteria. The interventions identified involved

Background: Using an optical method based on tunable diode laser absorption spectroscopy, we previously assessed oxygen (O2) and water vapor (H2O) content in a tissue phantom of the preterm infant lung. Here we applied this method on newborn piglets with induced lung complications. Methods: Five mechanically ventilated piglets were subjected to stepwise increased and decreased fraction of inspired

High postprandial blood glucose levels are associated with increased mortality, cardiovascular events and development of diabetes in the general population. Interventions targeting postprandial glucose have been shown to prevent both cardiovascular events and diabetes. This study evaluates the efficacy and safety of a novel nutritional supplement targeting postprandial glucose excursions in non-di

The intrauterine milieu can have an impact on an individualʼs entire life. Restricted supply not only causes reduced growth, but also irreparable damage, e.g., cardiovascular or neurocognitive. Issues to be addressed by prenatal medicine include not only possible therapeutic aspects, but also the question of the optimal medical strategy, which aims to minimize damage from undersupply on the one ha

A two-dimensional mathematical model is used to investigate the performance and transport characteristics of PEM fuel cells with different membrane thicknesses. The overall cell performance of three cases are presented and compared. In addition, the local temperature, liquid water saturation, water content and current density distributions are analyzed and compared. Results show that performance i

COVID-19 became a stress-test for many legal systems because it required that a balance be found between rapid action to prevent the spread of the disease and a continued respect for human rights. Many states in Europe, including Ukraine, chose to enforce an obligation to self-isolate. In this article we review what the obligation to self-isolate entails in the case of Ukraine. We also analyse whe

We consider thermal fluid structure interaction with a partitioned approach, where typically, a finite volume and a finite element code would be coupled. As a model problem, we consider two coupled Poisson problems with heat conductivities $$\lambda _1$$, $$\lambda _2$$ in one dimension on intervals of length $$l:1$$ and $$l:2$$. Hereby, we consider linear discretizations on arbitrary meshes, such

Reaction mechanism validation for nitrogen-diluted ethane/nitrous oxide mixtures at stoichiometric conditions has been performed using ignition delay time measurements at p = 1, 4, and 16 bar as well as laminar flame speed measurements at p = 1 and 3 bar. The predictive capability of the public domain mechanism GRI 3.0 was improved considerably by adapting some reactions within the nitrogen subsys

Pheromones are environmentally friendly alternatives to traditional pesticides for pest control. They are widely applied for insect monitoring, mating disruption and mass trapping. Nicotiana benthamiana and N. tabacum are potential green biomass production platforms of moth sex pheromones. Using these two Nicotiana species as plant factories, we expressed biosynthetic genes of plant and insect ori

Purpose: This invited article explores current developments in supply chain risk management (SCRM) practices by revisiting the classical case of Ericsson (Norrman and Jansson, 2004) after 15 years, and updating its case description and analysis of its organizational structure, processes and tools for SCRM. Design/methodology/approach: An exploratory case study is conducted with a longitudinal focu

Biodiesel fuels are alternatives to petrodiesel, especially in the transport sector where they have lower carbon footprint. Notwithstanding the environmental benefit, biodiesel fuels may have other toxicological properties than petrodiesel. Particulate matter (PM) from petrodiesel causes cancer in the lung as a consequence of delivery of genotoxic polycyclic aromatic hydrocarbons, oxidative stress

The continuous growth of e-retail in the B2C sector has been generating new recordsin revenues for several years. This has led to diversification of the marketinteractions and actors that are involved and impacted by the respective operationsand trends. To address the rising demands from the different actors involved and tohelp manage the increasing complexity of the retail sector, technological s

Penguins face a major thermal transition when returning to land in a hypothermic state after a foraging trip. Uninsulated appendages (flippers and feet) could provide flexible heat exchange during subsequent rewarming. Here, we tested the hypothesis that peripheral vasodilation could be delayed during this recovery stage. To this end, we designed an experiment to examine patterns of surface rewarmPenguins face a major thermal transition when returning to land in a hypothermic state after a foraging trip. Uninsulated appendages (flippers and feet) could provide flexible heat exchange during subsequent rewarming. Here, we tested the hypothesis that peripheral vasodilation could be delayed during this recovery stage. To this end, we designed an experiment to examine patterns of surface rewarm

Marine endotherms in the polar regions face a formidable thermal challenge when swimming in cold water. Hence, they use morphological (fat, blubber) adjustment and peripheral vasoconstriction to reduce demands for heat production in water. The animals then regain normothermia when resting ashore. In the king penguin (Aptenodytes patagonicus) metabolic rate is lower in fed than in fasted individual

Objectives: Pain is the most common and troublesome complaint in rheumatoid arthritis (RA). This study aimed to assess the prevalence and clinical implications of unacceptable pain in an inception cohort of patients with RA. Method: This study followed 477 patients from the BARFOT (Better Anti-Rheumatic FarmacOTherapy) early RA cohort for 15 years. Unacceptable pain was defined as ≥ 40 mm on a vis

As institutional forms of political engagement continue to decline, participation in protests steadily become more common. These trends are particularly strong among younger citizens. Previous research indicates that social factors can explain participation in political protests, and that younger citizens’ participation in protests is more affected by social ties than older people’s participation.