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Sensory Overresponsivity and Symptoms Across the Obsessive-Compulsive Spectrum: Web-Based Longitudinal Observational Study

Background:Sensory overresponsivity (SOR) has emerged as a potential endophenotype in obsessive-compulsive disorder (OCD), but few studies have examined SOR in relation to the major symptom dimensions of OCD and to symptoms across the full obsessive-compulsive (OC) symptom spectrum.Objective:This study had 2 main objectives. First, we examined the psychometric properties of the SOR Scales in a com

Relationship between Cognitive Strategies of Emotion Regulation and Dimensions of Obsessive–Compulsive Symptomatology in Adolescents

Cognitive emotion regulation refers to the management of one’s emotions through cognitive strategies. Studies have found that individuals with obsessive–compulsive symptoms utilize emotion regulation strategies differently compared to those without these symptoms. This study aims to investigate the relationship between cognitive strategies for emotion regulation and specific dimensions of obsessiv

Polygenic scores of diabetes-related traits in subgroups of type 2 diabetes in India: a cohort study

BackgroundA machine-learning approach identified five subgroups of diabetes in Europeans which included severe autoimmune diabetes (SAID), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD) with partially distinct genetic aetiologies. We previously validated four of the non-autoimmune subgroup

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease

Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney disease (DKD) in Type 1 diabetes (T1D) with replication in Type 1 and 2 diabetes. Sequencing reproducibly s

Age and Referral Route Impact the Access to Diagnosis for Women with Advanced Ovarian Cancer

Purpose: The majority of women with ovarian cancer are diagnosed in late stages. Most women do have symptoms prior to diagnosis, sometimes several months before the diagnosis. The aim of this study was to evaluate the timeline from the first presentation of symptoms to a physician until there is a reasonable suspicion of cancer, among women diagnosed with advanced stage ovarian cancer. We wanted t

Tilt-Induced Changes in RR Series Characteristics : An AV Node Simulation Study

In the ECG recordings during tilt test, changes in RR series characteristics can be observed. The purpose of the present study is to investigate to what extent these changes can be explained by changes in the atrial input and in the atrioventricular (AV) nodal characteristics induced by the autonomic nervous system (ANS). Average RR series characteristics (mean, rmssd and sample entropy) and avera

Effects of Acetylcholine Release Spatial Distribution on the Frequency of Atrial Reentrant Circuits : a Computational Study

The frequency of the ECG fibrillatory f-waves (Ff) in atrial fibrillation (AF) shows significant variations over time. Cardiorespiratory interactions through the autonomic nervous system have been suggested to play a role in such variations. Here, we tested whether the spatial distribution associated with the release of the parasympathetic neurotransmitter acetylcholine (ACh) could affect the freq

Drug Dependent Circadian Variations in AV-nodal Properties During Atrial Fibrillation

The heart rate during atrial fibrillation (AF) is highly dependent on the conduction properties of the atrioventricular (AV) node, which can be affected using β-blockers or calcium channel blockers, often chosen empirically. Thus, characterization of the AV nodal conduction properties could contribute to personalized treatment of AF. We have created a mathematical network model of the AV node wher

Brain Tumor Imaging and Treatment Effects. Imaging findings and cognitive function in glioblastoma patients.

Hjärntumör inklusive glioblastom.Glioblastom är den vanligaste sortens hjärntumör bland vuxna och samtidigt den mest elakartade. Glioblastom drabbar cirka 550 personer årligen i Sverige. När tumören upptäcks är behandlingen först operation för exakt diagnos och med syfte att avlägsna så mycket som det går av tumören, utan att orsaka skada för patienten, annars görs en diagnostisk biopsi. StandardbAbstractBackground: Glioblastoma is the most common malignant brain tumor. Operation with maximal resection, if feasible, otherwise biopsy followed by radiotherapy and chemotherapy with temozolomide is standard therapy. The prognosis remains poor, with median overall survival being 15 months despite therapy. Improved monitoring and treatment response assessment will be important when seeking to im

Associations between birth parameters and skin autofluorescence advanced glycation end and ankle-brachial index in young adulthood : the Malmö Offspring Study

BACKGROUND: Low birth weight (LBW), advanced glycation end-products (AGE), and ankle-brachial index (ABI) have all been independently associated with risk of cardiovascular disease. Evidence is lacking on the effect of LBW on adult AGE, a marker of glucose metabolism, and ABI, a marker of peripheral atherosclerosis. The objective was to study these associations in a population-based cohort.METHODS

Evolutionary history of Euteliidae (Lepidoptera, Noctuoidea)

We performed a molecular phylogenetic analysis on the family Euteliidae to clarify deep divergences and elucidate evolutionary relationships at the level of the subfamily, tribe, and genus. Our dataset consists of 6.3 kbp of one mitochondrial and seven nuclear DNA loci and was analysed using model-based phylogenetic methods, that is, maximum likelihood and Bayesian inference. Based on the recovere

Support Needs Among Older Tenants Living in Public Housing in Sweden : Perspectives of Janitors and Maintenance Staff

Neighborhood support can improve aging in place for older adults, but research on the role of public housing staff in supporting older tenants is lacking. Twenty-nine participants (janitors, n = 11; maintenance staff, n = 18) collected data about critical situations among older tenants residing in apartments in Sweden. Modifying the Critical Incident Technique (CIT) and applying a mixed-methods de

The Growth of Food Aid in Sweden – How Demand and Supply are Transforming Charitable Organisations

The purpose of this article is to describe and analyse the growth in food aid in Sweden, and how it affects the non-profit organisations providing it. The particular type of food aid in focus is large-scale collaborations between charitable non-profit organisations and the food industry, through which food surplus is turned into food aid for people in food insecurity. The first examples of such fo

China’s Crisis Governance and Evolving State-Society Relations during the COVID-19 Pandemic

Existing studies on China’s COVID-19 response have gravitated to a macro-level,formal institutional analysis, focusing either on the effectiveness of the policy in early stage virus containment or on the growing negative impacts of COVID policy practices on China’s socio-political landscape at the late stage. Using serial interviewsaccompanied by online observations and documents, this thesis redi

Measurement of jet substructure in boosted Formula Presented events with the ATLAS detector using Formula Presented of 13 TeV Formula Presented collisions

Measurements of the substructure of top-quark jets are presented, using Formula Presented of 13 TeV Formula Presented collision data recorded with the ATLAS detector at the LHC. Top-quark jets reconstructed with the anti-Formula Presented algorithm with a radius parameter Formula Presented are selected in top-quark pair (Formula Presented) events where one top quark decays semileptonically and the

Search for magnetic monopoles and stable particles with high electric charges in (Formula presented.) TeV pp collisions with the ATLAS detector

We present a search for magnetic monopoles and high-electric-charge objects using LHC Run (Formula presented.) TeV proton-proton collisions recorded by the ATLAS detector. A total integrated luminosity of 138 fb−1 was collected by a specialized trigger. No highly ionizing particle candidate was observed. Considering the Drell-Yan and photon-fusion pair production mechanisms as benchmark models, cr

Performance of the ATLAS forward proton Time-of-Flight detector in Run 2

We present performance studies of the Time-of-Flight (ToF) subdetector of the ATLAS Forward Proton (AFP) detector at the LHC. Efficiencies and resolutions are measured using high-statistics data samples collected at low and moderate pile-up in 2017, the first year when the detectors were installed on both sides of the interaction region. While low efficiencies are observed, of the order of a few p

Rethinking (Human) bodies in HRI : Embodied interactions every day

Significant amounts of HRI research effort are spent on the design/evaluation of robot bodies. Critical discussion and debates concerning the way bodies are treated and considered within HRI have tended to focus on the implications of designing/interacting with highly anthropomorphic robots, yet drawing attention away from the human body in HRI, particularly in the context of everyday interactions

Ett intellektuellt proletariat : Fackliga strategier bland svenska folkbibliotekarier

The Swedish public librarians’ union (SFF) was founded in 1938 and joined the larger DIK union in 1972. SFF’s roots can be traced back to a union of library assistants at Stockholm’s library. From its start, SFF fought for higher wages and improved status for public librarians. SFF’s repertoire for collective confrontations consists of methods inspired by theworkers’ and civil servants’ movements.

Citizens’ experiences of enablers and barriers to obtaining digital citizenship: : E-applications for social assistance

This article focuses on citizens’ experiences of enablers of- and barriers to obtaining digital citizenship. E-applications for social assistance are used as an exemplar. In Sweden, as in many countries, there is political pressure on welfare services to become more digitalized, and to offer different kinds of self-service technology such as e-applications. Even if the goals of implementing these