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Neuroblastoma patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates to aggressive disease. Here we define a role for the hypoxia inducible factor-2α in neuroblastoma tu
This thesis adds to the knowledge base of how the Individual Placement and Support (IPS) can be optimized to secure a more sustainable working career for people with severe mental illness (SMI). The thesis has given the IPS-participants an active voice about what it is like to start to work in a Swedish context, visualised the psychiatric disability in relation to work, discerned the support and p
We calculated average aquatic dissolved organic carbon (DOC) age (the time span from soil discharge to observation) in water from the inlets and outlets of two unproductive Swedish lakes at different times during an annual cycle. Bacterial production (BP) and bacterial growth efficiency (BGE) determined during 7-d bioassays decreased with increasing average aquatic DOC age. Parallel to the decline
Purpose: To investigate differences in calculated doses and normal tissue complication probability (NTCP) values between different dose algorithms. Methods: Six dose algorithms from four different treatment planning systems were investigated: Eclipse AAA, Oncentra MasterPlan Collapsed Cone and Pencil Beam, Pinnacle Collapsed Cone and XiO Multigrid Superposition, and Fast Fourier Transform Convolut
Some of the main bottlenecks for the development and commercialization of photovoltaic/thermal hybrids are the lack of an internationally recognized standard testing procedure as well as a method to compare different hybrids with each other and with conventional alternatives. A complete methodology to characterize, simulate and evaluate concentrating photovoltaic/thermal hybrids has been proposed
The PHENIX experiment at the Relativistic Heavy Ion Collider has measured omega meson production via leptonic and hadronic decay channels in p + p, d + Au, Cu+ Cu, and Au + Au collisions at root s(NN) = 200 GeV. The invariant transverse momentum spectra measured in different decay modes give consistent results. Measurements in the hadronic decay channel in Cu Cu and Au + Au collisions show that. p
By examining trends in intra-organizational and inter-organizational job transition probabilities among professional and managerial employees in Germany, we test the applicability of mainstream career theory to a specific context and challenge its implied change assumption. Drawing on data from the German Socio-Economic Panel (GSOEP), we apply linear probability models to show the influence of tim
The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. Therefore it is important to investigate the role of LTD4 signalling in cancer development and progression. In this thesis I show that there is an end
Three accelerator prototype cryomodules (CMs) for the European XFEL have been produced, assembled and tested at DESY in a wide international collaboration. The heat load budget is a key element in the qualification of these CMs. We describe in this paper the measurements performed in the Cryomodule test bench (CMTB) to evaluate the thermal performances of the three prototype CMs. We present at fir
We give a brief overview of the basics and current developments of QCD-based calculations of radiative processes in medium. We put an emphasis on the underlying physics concepts and discuss the theoretical uncertainties inherently associated with the fundamental parameters to be extracted from data. An important area of development is the study of the single-gluon emission in medium. Moreover, est
Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndrome (MCLMR) is a rare autosomal dominant disorder with variable expressivity. It is characterized by mild-to-severe microcephaly, often associated with intellectual disability, ocular defects and lymphedema. It can be sporadic or inherited. Eighty-seven patients have been described to carry a mutation in KIF11,
Digital subscriber lines (DSLs) technology is vastly used for high-speed data transmission. Crosstalk is one of the main problems in DSL. The research community has done extensive work on how to optimize spectrum allocation across DSL frequencies and mitigate crosstalk, a subject that has been called dynamic spectrum management (DSM). This text presents a novel DSM solution, referred to as semibli
The cyclopentanone and cyclopentenone group of fragrance ingredients was critically evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.002% to 15.16% in hydroalcoholic products; systemic exposures vary from 0.0003 to 0.7122 mg/kg/day. The cyclopentanones and cyclopentenones had a low order of acute toxicity and no signif
Background: Research in recent decades increasingly indicates the importance of conditions in early life for health in adulthood. Only few studies have investigated socioeconomic conditions in both childhood and adulthood in relation to health testing the risk accumulation, critical period, and social mobility hypotheses within the same setting. This study investigates the associations between eco
Context: Scope management is a core part of software release management and often a key factor in releasing successful software products to the market. In a market-driven case, when only a few requirements are known a priori, the risk of overscoping may increase. Objective: This paper reports on findings from a case study aimed at understanding overscoping in large-scale, market-driven software dev
Background: Acetyl Coenzyme A carboxylase beta (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Systematic human studies have not been performed to evaluate whether ACACB variants regulate gene expression and insulin sensitivity in skeletal muscle and adipose tissues. We sought to determine wheth
