Psychiatric symptoms such as depression and anxiety are important clinical features of Huntingtons disease (HD). However, the underlying neurobiological substrate for the psychiatric features is not fully understood. In order to explore the biological origin of depression and anxiety in HD, we used a mouse model that expresses the human full-length mutant huntingtin, the BACHD mouse. We found that

Concentrating cells is a frequently performed step in cell biological assays and medical diagnostics. The commonly used centrifuge exhibits limitations when dealing with rare cell events and small sample volumes. Here, we present an acoustophoresis microfluidic chip utilising ultrasound to concentrate particles and cells into a smaller volume. The method is label-free, continuous and independent o

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of

Purpose – The purpose of this paper is to look more closely at the residents’ attitude to individual heat metering and charging systems (IMC) of multi-family dwellings in residential properties, and to evaluate the tenant’s perception of IMC and how it may affect the continued expansion of such systems. Design/methodology/approach – The research in this paper is based on a questionnaire and interv

A search is performed for top-quark pairs (t (t) over bar) produced together with a photon (gamma) with transverse energy greater than 20 GeV using a sample of t (t) over bar candidate events in final states with jets, missing transverse momentum, and one isolated electron or muon. The data set used corresponds to an integrated luminosity of 4.59 fb(-1) of proton-proton collisions at a center-of-m

The potential machinability for Alloy 718 (Inconel 718) is examined in terms of five material characteristics considered to play a key role in the machinability: ductility (elongation to fracture), strain hardening (ultimate tensile strength over yield strength), thermal conductivity, yield strength and abrasiveness (amount of carbides). The material characteristics are simulated with the software

Results of a search for H -> tau tau decays are presented, based on the full set of proton-proton collision data recorded by the ATLAS experiment at the LHC during 2011 and 2012. The data correspond to integrated luminosities of 4.5 fb(-1) and 20.3 fb(-1) at centre-of-mass energies of root s = 7TeV and root s = 8 TeV respectively. All combinations of leptonic (tau -> l nu(nu) over bar with l = e,

Purpose – This paper aims to investigate the strategies used by Swedish citizens to adapt to changing climate variability and extremes. There is an increasing consensus that individual adaptive capacities are critical to successfully adapt to climate change and achieve sustainable development. However, little is known about individual adaptive practices, particularly in developed countries. Design

Interactions between iron (Fe) and arsenic (As) play a vital role in aquatic and terrestrial ecosystems influencing the reactivity and transport of arsenic. A key aspect is the effect of natural organic matter (NOM) on these interactions, and previous investigations have reported the existence of ternary As-Fe-NOM species. In this study, the reactivity of Fe, from a boreal stream water, towards As

The mechanisms for oxygen etching of graphene on Ir(111) are uncovered through a systematic variation of the graphene morphology - ranging from an impermeable graphene layer to graphene nanoflakes - and the application of complementary experimental methods, including scanning tunneling microscopy, X-ray photoelectron spectroscopy, and temperature programmed desorption. Associated with a strong var

This study describes an efficient isolation procedure for the extraction of polar lipids from two strains of bifidobacteria - Bifidobacterium longum and Bifidobacterium angulatum. We first compared the lipid profiles of two strains of bifidobacteria and showed that the strains of the same genus may differ by lipid composition of cell walls. The polar lipids were isolated using the following condit

We argue that our common diseases should not necessarily be taken as a sign of physiological error. Regulatory networks developed by evolutionary forces to support reproductive fitness happen to include disease as a side-effect. For example, inflammatory and autoimmune diseases are secondary to a strong defence against infections. An evolutionary perspective can help us understand why many drugs t

Six different ionomers having various aromatic polymer backbones with pendant 2-sulfobenzoyl side chains were prepared by nucleophilic aromatic substitution reactions of lithium 2,6-difluoro-2′-sulfobenzophenone with 4,4-biphenol, 2,7-dihydroxynaphthalene, 4,4-isopropylidenediphenol, 4,4-dihydroxydiphenyl ether, 4,4′-thiodiphenol, and 4,4′-thiobisbenzenethiol, respectively, to produce four poly(ar

Matrix metalloproteinase-9 (MMP-9) regulates platelet shedding of CD40L in abdominal sepsis. However, the signaling mechanisms controlling sepsis-induced shedding of CD40L from activated platelets remain elusive. Rac1 has been reported to regulate diverse functions in platelets; we hypothesized herein that Rac1 might regulate platelet shedding of CD40L in sepsis. The specific Rac1 inhibitor NSC237

Background Small studies suggest that postconditioning reperfusion interrupted by brief repetitive cycles of reocclusions, may protect the myocardium in the clinical setting. Objective To test the hypothesis that postconditioning limits infarct size in relation to the area at risk in patients with ST elevation myocardial infarction (STEMI). Methods 76 patients (aged 37-87 years) eligible for prima

Entanglement between spatially separated electrons in nanoscale transport is a fundamental property, yet to be demonstrated experimentally. Here we propose and analyse theoretically the transport statistics of a generic spin entangler coupled to a hybrid quantum dot-ferromagnet detector system. We show that the full distribution of charges arriving at the ferromagnetic terminals provides complete

We investigated atmospheric aerosol particle dynamics in a boreal forest zone in northern Scandinavia. We used aerosol number size distribution data measured with either a differential mobility particle sizer (DMPS) or scanning mobility particle sizer (SMPS) at three stations (Varrio, Pallas and Abisko), and combined these data with the HYSPLIT (Hybrid Single Particle Lagrangian Integrated Traject

Immune system is highly integrated with the nervous and endocrine systems, which is thought to result in covariation between behavioural syndromes and stress- and immune-associated diseases. Very little is known about the associations between behaviour and immune traits in wild animals. Here we describe such an association in passerine birds, the greenfinches (Carduelis chloris). When wild-caught