Search results
Filter
Filetype
Your search for "*" yielded 532650 hits
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148
Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma r
Exposing drug industry funding of UK patient organisations
From 2012 to 2016 the drug industry donated over £57m (€65m; $73m) to UK patient organisations, with the annual sum more than doubling over the period. The funding benefited a small number of organisations and activities related to research and public involvement. The industry gave priority to commercially high profile conditions. Industry payment disclosures had limited transparency
Man against machine : diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists
Background: Deep learning convolutional neural networks (CNN) may facilitate melanoma detection, but data comparing a CNN's diagnostic performance to larger groups of dermatologists are lacking.Methods: Google's Inception v4 CNN architecture was trained and validated using dermoscopic images and corresponding diagnoses. In a comparative cross-sectional reader study a 100-image test-set was used (l
Meniscal tear - A feature of osteoarthritis
Meniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?
Degenerative meniscal lesions : Indications
Degenerative meniscus lesions, cartilage degeneration, and osteoarthritis of the knee
Patient reported outcomes in patients undergoing arthroscopic partial meniscectomy for traumatic or degenerative meniscal tears : comparative prospective cohort study
OBJECTIVES: To compare patient reported outcomes from before surgery to 52 weeks after surgery between individuals undergoing arthroscopic partial meniscectomy for traumatic meniscal tears and those for degenerative meniscal tears.DESIGN: Comparative prospective cohort study.SETTING: Four public orthopaedic departments in the Region of Southern Denmark. Participants were recruited between 1 Februa
Author reply : To PMID 24800623
Public entrance accessibility: assessment instrument to support participation for all
Att följa sitt ideal : Den vägledande anden i Salomos vishet och hos Dion Chrysostomos
Making Many Kinds of Moral Progress : A Review of The Evolution of Moral Progress by Allen Buchanan and Russell Powell
Rethinking the relation between the physical home environment and functional decline path
Så verkar vi för minskad köttkonsumtion
Forskare har ett särskilt ansvar i klimatfrågan, menar Emma Kritzberg vid Lunds universitet. Hon är en av dem som verkat för vegetariskt som standardval vid biologiska institutionen.
Seawalls and the Tyranny of Small Decisions
Transancestral mapping and genetic load in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (50% of these regions have multiple independe
Perceived and objective aspects of home and health: aging in place in Japan and Sweden
Contact activation products are new potential biomarkers to evaluate the risk of thrombotic events in systemic lupus erythematosus
Introduction: Patients with systemic lupus erythematosus (SLE) have persistent platelet activation and an increased risk of thrombotic events, which cannot be accounted for by traditional cardiovascular risk factors. Factor (F)XII has a potentially important role in thrombus formation and is triggered by activated platelets. We therefore asked whether the contact system is involved in inflammation
Cold, poor and frail: a cross-sectional study with community dwelling older people in Japan
Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus
Introduction: The ability to degrade neutrophil extracellular traps (NETs) is reduced in a subset of patients with systemic lupus erythematosus (SLE). NETs consist of chromatin covered with antimicrobial enzymes and are normally degraded by DNase-I, an enzyme which is known to have reduced activity in SLE. Decreased ability to degrade NETs is associated with disease activity. In the current study