Background: Real-world data on demographics related to KRAS mutation subtypes are crucial as targeted drugs against the p.G12C variant have been approved. Method: We identified 6183 NSCLC patients with reported NGS-based KRAS status in the Swedish national lung cancer registry between 2016 and 2019. Following exclusion of other targetable drivers, three cohorts were studied: KRAS-G12C (n = 848), K

De styrmedel som används i Sverige för att hantera övergödning från vattenbruket kan ha bidragit till att sektorns tillväxt är låg. Idag används främst fodertak, som anger hur mycket foder som får användas, och subventioner för att minska näringsutsläpp och öka näringsupptag från vattenbruket.Nya styrmedel för minskad övergödning kan öka det svenska vattenbrukets tillväxt. Exempelvis kan ett tak p

EU-kommissionen har lagt fram ett förslag på nytt energiskattedirektiv som innebär att yrkesfisket kan komma att betala bränsleskatt. Detta medför i så fall ökade kostnader och lägre lönsamhet för yrkesfisket inom EU. Syftet med denna studie är att undersöka hur fisket kan anpassa sig till en bränsleskatt genom att på olika sätt minska sin bränsleförbrukning.Våra resultat visar att fisket kan mins

Stora tekniksprång i samhället ställer nya krav på arbetskraftens kvalifikationer. Efterfrågan på högkvalificerad arbetskraft ökar men även nya lågkvalificerade jobb kan bli vanligare. Man talar om en jobbpolarisering där medelkvalificerade jobb ersätts av både hög- och lågkvalificerade jobb. Finns det jobbpolarisering i Sverige? Hur påverkas företagen och skiljer sig jobbpolariseringen åt mellan

The human brain is a masterpiece of intricate design and impeccable functionality. It serves as the ultimate command center for our thoughts, sensations, and actions, which define our very existence. This organ operates flawlessly, with billions of neurons working in perfect harmony to process information, create memories, and regulate our emotions. The brain's neural network is composed of trilli

BACKGROUND: Interstitial lung disease (ILD) is the most common cause of death in patients with systemic sclerosis (SSc). Prognostic biomarkers are needed to identify SSc-ILD patients at risk for progressive pulmonary fibrosis. This study investigates autoantibodies measured in bronchoalveolar lavage (BAL) fluid and in serum in reference to the clinical disease course of SSc-ILD.METHODS: Fifteen pa

The project focuses on Sweden's growing parcel locker networks used for e- commerce delivery. These lockers have the potential to improve e-commerce logistics' operational and environmental performance if efficiently designed. To achieve this and promote sustainability in Sweden's e-commerce market, effective policy tools are essential.The project aims to advance knowledge on parcel locker network

BACKGROUND: Among infants with isolated cleft palate, whether primary surgery at 6 months of age is more beneficial than surgery at 12 months of age with respect to speech outcomes, hearing outcomes, dentofacial development, and safety is unknown. METHODS: We randomly assigned infants with nonsyndromic isolated cleft palate, in a 1:1 ratio, to undergo standardized primary surgery at 6 months of ag

Concern for the health of the natural environment is growing as humanpopulation grows. Recently, renewed attention has been given to the environmentalimpact of fires and the fire implications of sustainability choices made in the builtenvironment. To properly understand the environmental impact of fires, however, itis crucial that we can estimate fire emissions. This paper explores the concept of

This thesis explores the physics of nanostructures involving nanowires, quantum dots, superconductors, and topological insulators. These systems serve as excellent platforms for fundamental physics studies and quantum technology applications.The introduction contains information on the band structures of crystalline materials and transport phenomena in quantum dots. It is followed by discussions o

Interactions of lipid vesicles play important roles in a large variety of functions and dysfunctions in the human body. Vital for several biochemical functions is the interaction between monomeric proteins and lipid membranes, and the induced phenomena such as fusion between vesicles and cell membranes, lipid exchange between the membranes, or vesicle fission. Identification of single events and t

BACKGROUND: Oestrogen receptor alpha (ER) is involved in cell growth and proliferation and functions as a transcription factor, a transcriptional coregulator, and in cytoplasmic signalling. It affects, for example, bone, endometrium, ovaries and mammary epithelium. It is a key biomarker in clinical management of breast cancer, where it is used as a prognostic and treatment-predictive factor, and a

α-Synuclein (α-Syn), is an intrinsically disordered protein present in the substantia nigra part of the brain. α-Syn is commonly known to associate with lipid membranes containing anionic lipids. Hence, the protein is hypothesized to be involved in the vesicle trafficking at the synapses, but there are yet many unanswered questions regarding the full physiological role of the protein. During the d

During the past decade, many parliamentary democracies have experienced bargaining delays when forming governments. The previous literature has attributed protracted government formation processes to a high degree of preference uncertainty among the political parties and a high level of bargaining complexity. The article draws on such theories, but also adds a third theoretical mechanism, commitme

[The project Millora 2.0: Results 2018–2022] Based on repeated yearly surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southernmost Sweden, analysed in combination with speciesspecific traits and ecological indicator values (EIVs), changes in the flora and vegetation over the last four years are reported. Many of the changes observed, such as significant increasesBased on repeated yearly surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southernmost Sweden, analysed in combination with speciesspecific traits and ecological indicator values (EIVs), changes in the flora and vegetation over the last four years are reported. Many of the changes observed, such as significant increases in lightdemanding, shortlived, pollinatorind