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Taboo obsessions and their association with suicidality in obsessive-compulsive disorder

Individuals with obsessive-compulsive disorder (OCD) more often think about, attempt, and die by suicide than individuals from the general population. Sexual and religious obsessions (i.e., taboo obsessions) have been linked to increased risk of suicidality, but it is unclear if they explain additional risk over and above other risk factors. We refined the recently proposed multidimensional hierar

Self-imposed Filter Bubbles : Selective Attention and Exposure in Online Search

It is commonly assumed that algorithmic curation of search results creates filter bubbles, where users’ beliefs are continually reinforced and opposing views are suppressed. However, empirical evidence has failed to support this hypothesis. Instead, it has been suggested that filter bubbles may result from individuals engaging selectively with information in search engine results pages. However, t

Networks of inflammation, depression, and cognition in aging males and females

BackgroundPrioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.AimsTo explore the interactive network of inflammation, depression and cog

Circulating Growth Differentiation Factor 15 Levels Are Associated With Risk of Both Intracerebral and Subarachnoid Hemorrhage

Background: Growth differentiation factor 15 (GDF-15) has been associated with the risk of developing major bleedings, including but not restricted to intracranial hemorrhages, in patients on oral anticoagulants or dual antiplatelet therapy. We hypothesized that there may be an association of GDF-15 with incidence of hemorrhagic strokes in the general population, which has not been investigated be

Professionals´ readiness for change to knowledge-based palliative care at nursing homes : a qualitative follow-up study after an educational intervention

Background: There has been a global increase in the number of people who are dying of old age. This development implies a need for good palliative care among older persons at the end of life. Here nursing homes have an important role to play. However, the principles of palliative care have not been sufficiently applied in nursing homes, and there is a need to increase the implementation of palliat

Parametric analysis of drug distribution during infusions into the brain using an axisymmetric model with backflow

Convection-enhanced delivery as a means to deliver therapeutic drugs directly to the brain has shown limited clinical efficacy, primarily attributed to the phenomena of backflow, in which the infused fluid flows preferentially along theshaft catheter rather than forward into the tissue. We have previously developed a finite element model of backflow that includes both material and geometric nonlin

Transformative innovation policy : A novel approach?

The focus and instruments of innovation policy have changed fundamentally over the last decades. Recently transformative innovative policy has caught the attention of scholars and policymakers, who argue that this is a new shift in the policy discourse. Even though grand challenges such as global warming and migration flows, as well as technological change such as artificial intelligence and indus

Leadership and governance challenges in delivering place-based transformation through Smart Specialisation

This paper considers the unfolding of Smart Specialisation Strategy (RIS3) in one of Europe’s innovation-leading metropolitan regions: Stockholm, Sweden. Theoretically, it contributes to debates around change agency and reflects more broadly, which implications arise for metropolitan innovation-leader regions and which are of more generic nature. It argues that actor endowments, dense networks, ex