Reduction of cellular polyamine pools results in inhibition of cell proliferation and sometimes in induction of cell death. Reduction of cellular polyamine pools can be achieved by several strategies involving all the mechanisms of polyamine homoeostasis, i.e. biosynthesis, catabolism and transport across the cell membrane. In the present paper, we concentrate on results achieved using the polyami

Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while

The isoflurane-saving and CO2-retaining effects of a charcoal filter were compared with a Siemens standard heat and moisture (HME) exchanger and an emptied specimen (dummy). Isoflurane was delivered during the inspiratory phase and consumption investigated at 10, 15 and 25 cycles min-1. The investigation was performed by ventilation with humidified air with a constant end-tidal CO2 and temperature

It is known that ethnicity is a risk factor for diabetes. Thus, individuals of African, Latin American, and Asian descent are particularly susceptible (1). As an example, a health survey in six urban areas in Peru found a diabetes prevalence of 17% among women (2,3). It was also found that low socioeconomic status was associated with a high burden of noncommunicable diseases and appeared as an ind

High-risk human papillomavirus (HPV) types cause most cervical carcinomas and are sexually transmitted. Sexual behavior therefore affects HPV exposure and its cancer sequelae. The International Collaboration of Epidemiological Studies of Cervical Cancer has combined data on lifetime number of sexual partners and age at first sexual intercourse from 21 studies, or groups of studies, including 10,77

Simultaneous, spatially resolved monitoring of C2 and OH in a flame is reported. Data could be captured in 10 ns employing two pulsed lasers and a diode array detector. Laser-production of C2 was also observed and a kinetic study of such molecules was performed.

The aim of the study was to assess the short-term cardiorespiratory effects of a standard red cell transfusion in very low birth weight (

This is an exploratory study of the use of wh-questions in Swedish children with typical and impaired language development. Swedish is a verb-second (V2) language where inverted word order is not unique to wh-questions, but occurs in all utterances that begin with a constituent other than the subject. The purpose was to investigate types and frequency patterns in the use of wh-questions, wh-word a

Pathophysiological activity and various kinds of traumatic insults are known to have deleterious long-term effects on neuronal Cl- regulation, which can lead to a suppression of fast postsynaptic GABAergic responses. Brain-derived neurotrophic factor (BDNF) increases neuronal excitability through a conjunction of mechanisms that include regulation of the efficacy of GABAergic transmission. Here, w

In this paper, we present and discuss results from an investigation of verb placement in modern Faroese in which we collected data from speakers from a number of different dialect areas in the Faroe Islands. Altogether we interviewed 54 informants (age 15 – 67, 29 women and 25 men). Therefore, our study not only investigates the geographical variation claimed to be present in Faroese with respect

Near-infrared (NIR) spectroscopy is a useful technique for quantitative measurements of intact tablets, but it suffers from limitations due to the fact that changes in the physical properties of a sample strongly affect the recorded spectrum. In this work, time-resolved transmission NIR spectroscopy was utilized to conduct quantitative measurements of intact tablets. The technique enables separati

Transcranial magnetic stimulation (TMS) with weak (micro Tesla) complex waveform fields have been claimed to evoke the sensed presence of a sentient being in up to 80% in the general population. These findings have had a questionable neurophysiological foundation as the fields are approximately six orders of magnitude weaker than ordinary TMS fields. Also, no independent replication has been repor

Climatic warming leads to the expansion of deciduous shrubs and trees in the Arctic. This leads to higher leaf litter inputs, which together with warming may alter the rate of carbon and nutrient cycling in the arctic ecosystems. We assessed effects of factorial warming and additional litter on the soil ecosystem of a subarctic heath in a 7-year-long field experiment. Fine root biomass, dissolved

Accurate assessment of human intake of mutagenic/carcinogenic heterocyclic ainines (HAs) is necessary for epidemiological studies and future risk assessment. Using questionnaires, the frequency of consumption of specific dishes can be obtained at an individual level and linked to analyzed concentrations of different compounds in corresponding dishes. Some typical Swedish cooked meat dishes, hambur

Immune responses against oxidized forms of LDL play a critical role in activation and regulation of the inflammatory process that characterizes all stages of atherosclerosis. In humans oxidized LDL is targeted by both IgM and IgG autoantibodies. Immunization of hypercholesterolemic animals with oxidized LDL has been shown to inhibit atherosclerosis demonstrating that at least some of these immune

In this Letter we consider the evolution of a planetary system around a star inside a wide binary. We simulate numerically the evolution of the planetary orbits for both coplanar and highly inclined systems. We find that the Kozai mechanism operates in the latter case. This produces a highly eccentric outer planet the orbit of which crosses those of some of the inner planets. Strong planet-planet

The visual content of out-of-body experiences (OBEs) has received little attention but a number of theories of OBEs include implicit predictions regarding the determinants of this phenomenological feature. Hypnagogic imagery and unusual sleep experiences, weak synaesthesia and preference for employing object and spatial visual imagic cognitive styles were psychometrically measured along with the i

Background: Legislation was passed in Sweden to stimulate the development of different housing solutions for persons suffering from severe mental illness. Among these solutions are small congregate residences built in the community to provide suitable housing and support for those not able or willing to live independently. Aims: The general aim of the present study was to compare the psychosocial