BACKGROUND: Collagen-induced arthritis (CIA) is the most commonly used model of rheumatoid arthritis (RA). In both CIA and RA there is an increase in the cellular content of the synovium, this being dominated by macrophages. OBJECTIVE: To assess the impact of etoposide, a topoisomerase II antagonist known to induce monocyte apoptosis, on the development of CIA. METHODS: Mice were primed and booste

Cationic surfactants associate strongly to DNA and compact but are often toxic. The interaction of some novel cationic amino acid-based surfactants, which may enhance transfection and appear to be nontoxic, is described. A cationic arginine-based surfactant, ALA, gives in combination with anionic surfactants spontaneously stable vesicles, and special attention is given to the association of these

Letters and notes that expose collaboration in and between different creative networks and ethical-political theorists, governmental counsellors and personalities from 1886 to 1928 are now more accessible in the Anna Bugge Wicksell collection at the University Library of Lund. Anna Bugge Wicksell had central functions in The Neutral Conference for Continuous Mediation, after which she was co-opted

We present a high-resolution ( R= 75 000, S/ N ) spectroscopic analysis of the bright ( V= 11.7), extreme halo giant CS 31082-001([Fe/H] = -2.9), obtained in an ESO-VLT Large Programme dedicated to very metal-poor stars. We find CS 31082-001 to be extremely rich in r-process elements, comparable in this respect only to the similarly metal-poor, but carbon-enriched, giant CS 22892-052. As a result

High-spin states in Nb-85 were studied using the GAMMASPHERE Ge detector array and the MICROBALL charged-particle detector system. Three gamma-ray cascades with collective rotational characteristics were observed. One of the bands exhibits a forking at the top, most likely reflecting the termination of one branch into a favoured non-collective, near spherical state. The data are interpreted in ter

Agarose gels have long been known to produce exceptionally large enhancements of the water H-1 and H-2 magnetic relaxation rates. The molecular basis for this effect has not been clearly established, despite its potential importance for a wide range of applications of agarose gels, including their use as biological tissue models in magnetic resonance imaging. To resolve this issue, we have measure

Breast cancer is the most common disease in women, and up to 38% develop lymphedema of the arm following mastectomy, standard axillary node dissection and postoperative irradiation. Limb reductions have been reported utilising various conservative therapies such as manual lymph and pressure therapy. Some patients with long-standing pronounced lymphedema do not respond to these conservative treatme

Electricity bought and sold on the deregulated Nordic power market is dominated by hydro power. However, hydro power generation is restricted by the amount of water in reservoirs. The inflows to these reservoirs show a yearly cycle and seasonal planning of the production is necessary. Seasonal planning up to 1.5 years for a power producer in a hydro-thermal system with a regulated river is consid

Solitary-wave solutions of a nonlinearly dispersive equation are considered. It is found that solitary waves are peaked or smooth waves, depending on the wave speed. The stability of the smooth solitary waves also depends on the wave speed. Orbital stability is proved for some wave speeds, while instability is proved for others.

Purpose: To suggest a more precise tool when assessing the risk of contrast-medium-induced nephropathy (CIN), i.e. the ratio between contrast medium (CM) dose expressed in grams of iodine (g-I) and estimated glomerular filtration rate in ml/min (eGFR; based on equations using serum-creatinine (s-Cr), weight, height, age, and/or sex), here named I-dose/GFR ratio. Material and Methods: A Medline sea

Proceeding from the assumption that metaphors as well as pictures are iconic signs, the present contribution studies what happens when metaphors occur in figurative pictures. The author distinguishes between primary iconicity, the recognition of which is a condition for the categorization of an object as a sign, and secondary iconicity, which is perceived only after an object has been categorized