Background: Severely delayed elimination of methotrexate (MTX) is difficult to predict in patients treated with high-dose MTX (HD-MTX), but it may cause life-threatening toxicity. It has not been defined how an increase in plasma creatinine can be best used as a predictor for severely delayed MTX elimination, thus providing a guide for therapeutic interventions to minimize renal toxicity. Methods

Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with unfavourable prognosis for patients with advanced stages of the disease. Refractory disease and advanced-stage disease require systemic therapy. We report on a rare case of an atypical predominantly CD8 + folliculotropic MF, a subtype of MF with poorer prognosis, in a 59-year-old woman. She was initially diagnosed with MF restric

Highly oxygenated organic molecules (HOM) are formed in the atmosphere via autoxidation involving peroxy radicals arising from volatile organic compounds (VOC). HOM condense on pre-existing particles and can be involved in new particle formation. HOM thus contribute to the formation of secondary organic aerosol (SOA), a significant and ubiquitous component of atmospheric aerosol known to affect th

This study sought to explore how Swedish parents who had commissioned surrogacy abroad experienced the process of parenthood recognition. The study consisted of in-depth interviews with five couples and 10 individuals representing 10 additional couples who had used surrogacy abroad, mainly in India. The construction of motherhood and fatherhood in the Swedish system contradicts how parenthood is d

This chapter covers transition metal complexes with phosphorus-based pincer ligands with a central sp3-hybridization. It primarily focusses on progress in the last 4 years. The ligand types covered in this chapter include those based on straight alkyl chains but also complexes based on cyclohexane, dibenzobarrelene, cycloheptatriene, and diarylmethane scaffolds.

Understanding the interaction between inhaled nanoparticles and pulmonary surfactant is a prerequisite for predicting the fate of inhaled nanoparticles. Here, we introduce a quartz crystal microbalance with dissipation monitoring (QCM-D)-based methodology to reveal the extent and nature of the biophysical interactions of polymer- and lipid-based nanoparticles with pulmonary surfactant. By fitting

Recent and exciting in vivo studies show that supplementation with the polyamine spermidine (Spd) is cardioprotective and prolongs lifespan in both mice and humans. The mechanisms behind Spd-induced cardioprotection are supposed to involve Spd-evoked stimulation of autophagy, mitophagy and mitochondrial respiration and improved the mechano-elastical function of cardiomyocytes. Although cellular up

To improve the overall heat transfer of supercritical carbon dioxide (SCO 2 ) in a horizontal circular tube, this study proposes a novel kind of tube with cylindrically concaves and fillets on the circular surface. Several tubes are designed accordingly to investigate various parameters like θ (sectorial angle of concaves), r 2 (radius of concaves), r 3 (radius of fillets) and n (number of con

Congenital thrombocytopenic purpura (TTP) is a rare but serious condition. We present a case of a 29-year-old woman, diagnosed with this disease in adulthood. The episode that led to diagnosis was triggered by quetiapine. She presented with neurological symptoms and laboratory findings including low platelets and elevated creatinine. Interestingly, the signs of hemolysis were very subtle. Her symp

The objective was to design a thin, flex card based personal dosemeter with low angular and energy dependence. It is based on silicon diodes that can measure the personal dose equivalent. Anisotropic conducting adhesive was used to connect the Si sensor to the flex card. Its intended use is for interventional radiology and after nuclear or radiological accidents, as it provides immediate detailed

Massively parallel sequencing holds great promise for new possibilities in the field of forensic genetics, enabling simultaneous analysis of multiple markers as well as offering enhanced short tandem repeat allele resolution. A challenge in forensic DNA analysis is that the samples often contain low amounts of DNA in a background that may interfere with downstream analysis. PCR inhibition mechanis

BackgroundLignin is a potential feedstock for microbial conversion into various chemicals. However, the microbial degradation rate of native or technical lignin is low, and chemical depolymerization is needed to obtain reasonable conversion rates. In the current study, nine bacterial strains belonging to the Pseudomonas and Rhodococcus genera were evaluated for their ability to grow on alkaline-tr

This article compares the opportunities that existed for trade union organisation by women and the scope for pursuing women’s issues in the Swedish Tailoring Workers’ Union (Skrädderiarbetareförbundet), the Swedish Textile Workers’ Union (Textilarbetareförbundet) and the Swedish Women’s Trade Union (Kvinnornas fackförbund). Trade union minutes are analysed using theories on women’s organisation, i

Lignin depolymerisation receives great attention due to the pressing need to find sustainable alternatives to fossil sources for production of fuels and chemicals. In this study, alumina-supported Cu–Mn and Ni–Mo catalysts were tested for oxidative depolymerisation of a technical lignin stream—sodium lignosulphonates—to produce valuable low-molecular-weight aromatics that may be considered for ap

A hybrid catalyst consisting of Zr-doped mesoporous silica (Zr-SBA-15) supports with intergrown Cu nanoparticles was used to study the effects of a catalyst’s chemical states on CO2 hydrogenation. The chemical state of the catalyst was altered by using tetraethyl orthosilicate (TEOS) or sodium metasilicate (SMS) as the silica precursor in the synthesis of the Zr-SBA-15 framework, and infiltration A hybrid catalyst consisting of Zr-doped mesoporous silica (Zr-SBA-15) supports with intergrown Cu nanoparticles was used to study the effects of a catalyst’s chemical states on CO2 hydrogenation. The chemical state of the catalyst was altered by using tetraethyl orthosilicate (TEOS) or sodium metasilicate (SMS) as the silica precursor in the synthesis of the Zr-SBA-15 framework, and infiltration

Under den tidigmoderna och förindustriella perioden arbetade en stor del av den unga, ogifta allmogebefolkningen i Sverige som tjänstefolk, som drängar och pigor i andras hushåll. Där var de legalt underordnade husbonden och matmodern enligt särskilda tjänstehjonsstadgor och de hade begränsade möjligheter att söka annan försörjning, samtidigt som de ofta delade arbete och vardag med husbondfolket.The aim of this thesis is to analyze the power relations of labour and gender in the servant institution during the agrarian revolution in Sweden. The positions of servant, master and mistress are analyzed theoretically as a gendered, contracted position with both economic and moral dimensions attached to them. The analysis is applied together with a theory on bases of power, which are those areas

The advantage of using nonlamellar lipid liquid crystalline phases has been demonstrated in many applications, such as drug delivery, protein encapsulation and crystallisation. We have recently reported that a mixture of mono- and diglycerides is able to form sponge-like nanoparticles (L 3 -NPs) with large enough aqueous pores to encapsulate macromolecules such as proteins. Here we use small ang