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Inclusive positive pion photoproduction

Inclusive π+ photoproduction below the Δ(1232) resonance has been measured from H, C, Ca, Sn, and Pb at laboratory angles of 51°, 81°, 109°, and 141° using tagged photons and ΔE-E plastic scintillator telescopes with 17-MeV thresholds. Particle identification involved both the determination of differential energy loss and the detection of the μ+ from the π+ decay. Double differential cross section

PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats

Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there is no existing therapeutic approach to delay or stop progression. Genetic, biochemical and pre-clinical studies have provided evidence that leucine-rich-repeat-kinase-2 (LRRK2) kinase is involved in the pathogenesis of PD, and small molecule LRRK2 inhibitors represent a novel potential therapeutic approach. Howeve

Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation

Parkinson's disease (PD) affects motor function through degenerative processes and synaptic transmission impairments in the basal ganglia. None of the treatments available delays or stops the progression of the disease. While α-synuclein pathological accumulation represents a hallmark of the disease in its idiopathic form, leucine rich repeat kinase 2 (LRRK2) is genetically associated with familia

Mitochondria and the Brain : Bioenergetics and Beyond

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the intera

Turbulent heat transfer characteristics of supercritical n-decane in a vertical tube under various operating pressures

To explore the effect of the operating pressure on the flow and thermal characteristics in a vertical tube with supercritical n-decane, the inner wall temperature along the streamwise direction, the applicability of empirical correlations and buoyancy criteria are studied firstly. The mechanisms in views of density distribution, velocity field, turbulence intensity, the thickness of the thermal bo

Pheromones and Barcoding Delimit Boundaries between Cryptic Species in the Primitive Moth Genus Eriocrania (Lepidoptera : Eriocraniidae)

Animal classification is primarily based on morphological characters, even though these may not be the first to diverge during speciation. In many cases, closely related taxa are actually difficult to distinguish based on morphological characters alone, especially when there is no substantial niche separation. As a consequence, the diversity of certain groups is likely to be underestimated. Lepido

Management and outcome of TaG3 tumours of the urinary bladder in the nationwide, population-based bladder cancer database Sweden (BladderBaSe)

Purpose: To investigate the management of TaG3 tumours of the urinary bladder using nationwide population-based data in relation to the prevailing guidelines, patients’ characteristics, and outcome. Materials and methods: The Bladder Cancer Data Base Sweden (BladderBaSe), including data from the Swedish National Register for Urinary Bladder Cancer (SNRUBC), was used to study all patients with TaG3

Russian Flag at the North Pole

Russia’s planting of a flag on the seabed at the North Pole in 2007 set off a flurry of concern about its maritime and territorial ambitions and the potential for international conflict in the Arctic. However, the law of the sea now renders moot traditional rules of the doctrine of discovery and occupation as manifestations of sovereignty. Thus, the Russian flag at the North Pole is meaningless in