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Biopsy sampling requirements for the estimation of muscle capillarization
The aim of this study was to determine the number of tibialis anterior biopsy samples and muscle fibers required to estimate the capillary supply of individual muscle fibers (C:F-i). C:F-i was calculated for 25 type 1 fibers in each of 8 images from 3 biopsies of 5 young healthy individuals. Sequential estimation analysis indicated that 50 fibers from one biopsy are sufficient to characterize the
A snapshot of terror: Acute posttraumatic reactions to the September 11 attack.
This paper reports on acute posttraumatic reactions and forms of coping to the September 11 attack. We conducted a survey within three weeks of the attack on a nationwide, representative sample of individuals 13 years or older (N = 3,134). Measures included the Stanford Acute Stress Reaction Questionnaire (SASRQ), the brief version of the COPE, and questions about demographics and attitudes toward
Mechanistic model for drug release during the lag phase from pellets coated with a semi-permeable membrane.
A new mechanistic model of drug release during the lag phase from coated pellets undergoing cracking in the coating due to the hydrostatic pressure built up inside the pellet has been developed. The model describes dynamically all the main release processes occurring during the lag phase in pellets coated with a semi-permeable membrane, i.e. the influx of solvent driven by the difference in osmoti
Hydrogeochemical properties of a salinity-affected coastal aquifer in western Japan
Coastal groundwater aquifers are often exposed to heavy pumping and consequently to risks of saltwater intrusion. In many cases, however, the observed increase in groundwater salinity can only be partly explained by actual saltwater intrusion from the sea. Other salinity-increasing processes may also significantly contribute to the total salt content of the groundwater. This paper describes a geoc
Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n = 95) and population-based healthy controls (n = 72) were analyzed by SELDI-TO
Transition probabilities and lifetimes in singly ionized rhenium
Transition probabilities and radiative lifetimes have been obtained for 45 transitions of Re II using a combination of radiative lifetime values obtained with the laser-induced fluorescence technique ( seven levels) and theoretical branching fractions. This new set of results, concerning ultraviolet and visible lines, will be useful in the future for investigating the composition of chemically pec
Carotid artery stenosis: contrast-enhanced MR angiography with two different scan times compared with digital subtraction angiography
Contrast enhanced magnetic resonance angiography (CE MRA) is a non-invasive alternative to conventional digital subtraction angiography (DSA). CE MRA is increasingly used as a complement to Duplex in the preoperative assessment of carotid artery stenosis. The purpose of this study was to determine if CE MRA could replace preoperative DSA. CE MRA with a scan time of 10 or 28 s was performed in 24 c
Inhibition of different intracellular signal cascades in human pancreatic cancer cells.
Application of the Selective Energy Transfer Model to Account for an Isokinetic Response in the Gas Phase Reductive Cleavage of Hydroxyl, Carbonyl and Carboxyl Groups from Benzene Over Nickel/Silica
The gas phase hydrodeoxygenation of a series of aromatic alcohols, aldehydes and acids has been examined over Ni/SiO2. Compensation behaviour is established with an isokinetic temperature (518 +/- A 21 K) that is consistent with with the point of intersection of the Arrhenius lines. This is accounted for using the Selective Energy Transfer model that is based on resonance between the catalytic Ni-
The presence of elafin, SLPI, IL1-RA and STNFalpha RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation.
Biopsy samples of head and neck carcinomas were investigated with regard to elafin, secretory leukocyte protease inhibitor (SLPI), interleukin 1-receptor antagonist [(IL)1-RA] and soluble tumour necrosis factor alpha receptor antagonist (STNFalpha RI). SLPI and elafin are serine protease inhibitors produced in the serous cells of the upper respiratory airways and in the keratinocytes, respectively
Simvastatin stimulates macrophage interleukin-1beta secretion through an isoprenylation-dependent mechanism.
Statin treatment inhibits oxidized lipoprotein-induced intracellular lipid accumulation (foam cell formation) and reduces plasma levels of inflammatory markers such as interleukin-1 beta The aim of the present study was to determine if simvastatin affected lipid accumulation in macrophages incubated with aggregated low density lipoproteins (AgLDL) and whether simvastatin had a direct effect on cyt
Cerebral haemodynamic and metabolic effects of hypnotics and analgesics
Abstract in French La sédation des patients neurochirurgicaux fait appel le plus souvent à une association hypnotique-analgésique. Leurs effets sur l'hémodynamique et le métabolisme cérébraux sont l'un des critères qui président au choix des produits. Les analgésiques utilisés seuls, ont peu d'effets sur le flux sanguin cérébral et la CMRO2. Certaines données de la littérature attribuent aux analg
The influence of time-dependent melting on the dynamics and precipitation production in maritime and continental storm clouds
Simulations of one maritime and four continental observed cases of deep convection are performed with the Hebrew University Cloud Model that has spectral bin microphysics. The maritime case is from observations made on 18 September 1974 during the Global Atmospheric Research Program's Atlantic Tropical Experiment ( GATE). The continental storm cases are those of summertime Texas clouds observed on
Nervous activity in a stem cell niche
Toward understanding nonparticipation in sigmoidoscopy screening for colorectal cancer
Understanding the reasons for nonparticipation in cancer screening may give clues about how to improve compliance. However, limited cooperation has hampered research on nonparticipant profiles. We took advantage of Sweden's comprehensive demographic and health care registers to investigate characteristics of all participants and nonparticipants in a pilot program for colorectal cancer screening wi
Interatrial conduction in the mechanisms of atrial fibrillation: from anatomy to cardiac signals and new treatment modalities.
Areas of slow conduction and conduction block are important prerequisites for re-entry known to underlie atrial fibrillation (AF). Experimental and clinical data show that AF is associated with global lowering of atrial propagation velocity and the presence of defects in the interatrial conduction routes. The increasing data from anatomical studies demonstrate the possible prerequisites for conduc
Accelerator mass spectrometry - an overview
The technique of accelerator mass spectrometry (AMS) has spread worldwide since its first demonstration 25 years ago. The equipment used today is very diverse and dedicated accelerators as well as old "nuclear physics machines" can be found in the nearly 50 AMS laboratories today. The most widely spread application of AMS is for radiocarbon dating. However, AMS with C-14 as well as with other long
Effects of data uncertainty in Swedish critical load assessment for forest soils.
The effects of input data uncertainty on the critical loads and exceedance estimates for Swedish forest soils was assessed using Monte Carlo simulations of the PROFILE model. The study focuses on the effects of data uncertainty on the 5%-ile critical load at 150 × 150 km resolution and the 95%-ile exceedance at 150 × 150 km and 50 × 50 km resolution. The results indicate that data uncertainty limi
Glycogen synthase deficiency (glycogen storage disease type 0) presenting with hyperglycemia and glucosuria: Report of three new mutations
Although glycogen storage disease type 0 (GSD0) is included in the differential diagnosis of ketotic hypoglycemia, it usually is not considered in the evaluation of glucosuria or hyperglycemia. We describe two children with GSD0, confirmed by mutation analysis, who had glucosuria and hyperglycemia. Because of the variable presentation of this disorder and previous dependence on liver biopsy to con