The advantages put forward for so-called Smart working may sound very appealing. However, it is unlikely that all stakeholder groups involved will benefit to the same extent, if at all. Many initiatives that seem to be aimed at development of Smart work systems can be seen to be flawed, since they are suggested to support empowerment but are expressed in terms of pre-defined ‘best practice’. This

Detta kapitel analyserar vad man kan kalla automatiserad policyimplementering på digitala plattformar och därmed kombinationen av normativitet och plattformisering. I kapitlet fokuseras betydelsen av de automatiserade verktyg där varianter av artificiell intelligens och maskininlärning används för att moderera och effektivisera olika informationsflöden. Här tecknas tre kategorier där plattformar a

Denna rapport ger en översikt av linjär optimal stokastisk kontroll. De fundamentala problemen formuleras och de centrala resultaten gives, utan bevis men med utförliga fysikaliska tolkningar. Användandet av siffermaskiner både för syntes och implementering behandlas. Vidare diskuteras några praktiska problem förenade med det optimala systemets realisering: val av samplingstid, reelltidsberäkning

The effective use of modern control theory requires suitable mathematical models of the objects to be controlled and of the disturbances. Paper machines have been controlled digitally for a long time. Digital control of basis weight and moisture content is in fact one of the few examples where a digital computer and sensors form a standard package. In spite of this there are still significant gaps

This paper presents analysis of a scheme for iterated identification and control design. The approach is based on least squares identification in closed loop and pole placement design. It has previously been shown that the criteria for control and identification are the same provided that the data filters are chosen properly. The iterated scheme may be viewed as a recursion in model parameters. Ea

Mitochondrial dysfunction is thought to be a hallmark of traumatic brain injury (TBI) and plays a pivotal role in the resulting cellular injury. Cyclophilin D-mediated activation of the mitochondrial permeability transition pore has been suggested to contribute to this secondary injury cascade. Cyclosporine possesses neuroprotective properties that have been attributed to the desensitization of mi

Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined MRI data with genome-wide association studies of body fat percentage (%) and metabolic traits

OBJECTIVE Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS In this study, patients with duration of type 1 diabetes >14 years and age at onset

Progression to clinical type 1 diabetes varies among children who develop b-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar profiles associated with various types of progression among 600 children from The

Accurate determination of the genetic diversity present in the HIV quasispecies is critical for the development of a preventative vaccine: in particular, little is known about viral genetic diversity for the second type of HIV, HIV-2. A better understanding of HIV-2 biology is relevant to the HIV vaccine field because a substantial proportion of infected people experience long-term viral control,

BACKGROUND: About 13-26% of all acute ischaemic strokes are related to non-valvular atrial fibrillation, the most common cardiac arrhythmia globally. Deciding when to initiate oral anticoagulation in patients with non-valvular atrial fibrillation is a longstanding, common, and unresolved clinical challenge. Although the risk of early recurrent ischaemic stroke is high in this population, early ora

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program

Objective To describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up. Methods The systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within 15 months of SLE diagnosis. MIs were reported and attributed on a specialised vascular event form. MIs

BACKGROUND: Genetic association studies have reported single-nucleotide polymorphisms (SNPs) at chromosome 19q13.3 to be associated with prostate cancer (PCa) risk. Recently, the rs61752561 SNP (Asp84Asn substitution) in exon 3 of the kallikrein-related peptidase 3 (KLK3) gene encoding prostate-specific antigen (PSA) was reported to be strongly associated with PCa risk (P 2.3 108). However, the bi

We explored determinants of depressive mood in adults with coronary artery disease and obstructive sleep apnea and response to positive airway pressure treatment in sleepy and non-sleepy phenotypes. In this secondary analysis of the RICCADSA trial conducted in Sweden, 493 cardiac patients with obstructive sleep apnea (n = 386) or no obstructive sleep apnea (n = 107) with complete Epworth Sleepines

Terrestrial biogeochemical feedbacks to the climate are strongly modulated by the temperature response of soil microorganisms. Tropical forests, in particular, exert a major influence on global climate because they are the most productive terrestrial ecosystem. We used an elevation gradient across tropical forest in the Andes (a gradient of 20°C mean annual temperature, MAT), to test whether soil

The elliptic flow of inclusive and direct photons was measured at mid-rapidity in two centrality classes 0–20% and 20–40% in Pb–Pb collisions at sNN=2.76 TeV by ALICE. Photons were detected with the highly segmented electromagnetic calorimeter PHOS and via conversions in the detector material with the e+e− pairs reconstructed in the central tracking system. The results of the two methods were comb