Background Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with genetic variants in the predisposition to the disease. A number of common variants have been associated with T2D but our knowledge of their ability to predict T2D prospectively is limited. Methods and Findings By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN

ResA is an extracytoplasmic membrane-bound thiol-disulfide oxidoreductase required for cytochrome c maturation in Bacillus subtilis. Previous biochemical and structural studies have revealed that the active-site cysteinyls cycle between oxidized and reduced states with a low reduction potential and that, upon reduction, a hydrophobic cavity forms close to the active site. Here we report in vivo st

Patients are supposed to be given care according to their needs. This concept is, however, difficult to define and patients and caregivers may have different opinions about a patient's needs. Twenty patients were interviewed and asked to give a definition of need, describe their needs while hospitalized and depict what they do to make sure their needs are fulfilled. Ten groups of needs were identi

Abstract. This paper presents an optimal predictor of level crossings, catastrophes, for autoregressive moving-average processes, and investigates the performance of the predictor. The optimal catastrophe predictor is the predictor that gives a minimal number of false alarms for a fixed detection probability. As a tool for evaluating, comparing and constructing the predictors a method using operat

Detailed mineral (rock) magnetic measurements, including high-resolution magnetic hysteresis loops, were carried out on three sediment cores recovered from the Reykjanes Ridge in the North Atlantic. Supported by physical grain-size analyses, titanomagnetite grain-size variations form a proxy of the speed of near-bottom currents and reveal a cyclic ""saw-tooth'' pattern between Dansgaard-Oeschger c

Abstract is not available. This is the final, accepted and revised manuscript of this article. Use alternative location to go to the published article. Requires subscription. The original publication is available at springerlink.com.

We propose a universal transformation from a many-boson state to a corresponding many-fermion state in the lowest-Landau-level approximation of rotating many-body systems, inspired by the Laughlin wave function and by the Jain composite-fermion construction. We employ the exact-diagonalization technique for finding the many-body states. The overlap between the transformed boson ground state and th

The chiral clusters [H4Ru4(CO)(12-n)(L)(n)] (n = 1, 2; L = NMDPP), 1,1-[H4Ru4(CO)(10)(L - L)] (L - L = DUPHOS, DIPAMP), 1,2-[H4Ru4(CO)(10)(DIOP)] and [{H4Ru4(CO)(10)(DIOP)}(2)] have been synthesized by derivatizing the parent carbonyl cluster [H4Ru4(CO)(12)] with the appropriate mono- or didentate chiral phosphine ligand. The phosphine-substituted clusters were found to be able to catalyze the ( a

Dietary phytoestrogens may play a role in chronic disease occurrence. The aim of our study was to assess the variability of plasma concentrations in European populations. We included 15 geographical regions in 9 European countries (Denmark, France, Germany, Greece, Italy, Spain, Sweden, The Netherlands, and UK) and a 16th region, Oxford, UK, where participants were recruited from among vegans and

The role of the enteric nervous system in intestinal inflammation is not fully understood and the plethora of cellular activities concurrently ongoing in vivo renders intelligible studies difficult. In order to explore possible effects of bacterial lipopolysaccharide (LPS) on enteric neurons we utilised cultured myenteric neurons from rat small intestine. Exposure to LPS caused markedly reduced ne

Image and flow cytometry was used to study the nuclear DNA content (ploidy) during the squamous cell carcinogenesis in the esophagus. The present retrospective study comprised 26 surgical specimens of squamous cell carcinomas (SCC) in patients who underwent surgery alone at the Department of Surgery in CHUV Hospital in Lausanne, between January 1992 and December 1999. We analyzed 53 healthy tissue

The cytogenetic evolution patterns in chronic myeloid leukemia (CML) after allogeneic ( allo) stem cell transplantation (SCT) are different from the ones observed in non-transplanted patients, a phenomenon suggested to be caused by the conditioning regime. We reviewed 131 CMLs displaying karyotypic evolution after SCT (122 allo, nine autologous (auto)), treated at Lund University Hospital or repor

The Land sensitivity equation is a well-known tool for comparing optical performance between eyes. Despite this, the equation has never been experimentally tested. Here, we present, to our knowledge, the first experimental validation of the equation. We have investigated different insect species active at different intensities, and possessing different types of compound eyes, to compare ratios of

Elevated levels of cyclin A1 expression have been implicated in acute myeloid leukemia and in male germ cell tumors. However, a role of cyclin A1 in tumorigenesis of prostate cancer has not been reported. In the present study, expression of cyclin A1 in patients with prostate cancer and a role of cyclin A1 in mediating expression of vascular endothelial growth factor ( VEGF) were investigated. Cyc

Biglyean and decorin are small chondroitin/dermatan sulphate proteoglycans in the extracellular matrix of connective tissue that belong to the family of structurally related proteoglycans called small leucine-rich repeat proteins. We show for the first time that biglycan and decorin induce morphological and cytoskeletal changes in fibroblasts, resulting in an increase in migration. Biglycan change

Two major events marked 2002 as a milestone year for the sustainable development agenda and in particular for the tourism sector. The declaration by the United Nations of 2002 as ‘International Year of Ecotourism’ (IYE), culminated in the organisation of the World Ecotourism Summit (WES) in May 2002. This was followed in August 2002 by the World Summit for Sustainable Development (WSSD), a global