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T.M. Scanlon’s version of contractualism has emerged as one of the most well-developed challengers to consequentialism. According to one of contractualism’s most appealing features—the Individualist Restriction—the justifiability of our actions depends solely on the personal reasons of single individuals. While it allows contractualism to avoid many of consequentialism’s most implausible implicati
Background The COVID-19 pandemic has underlined the essential role of primary healthcare (PHC) in epidemiological surveillance and public health decision-making. Across Europe, the integration of electronic health records (EHRs) and the sentinel networks have been pivotal in monitoring COVID-19. However, the lack of standardized PHC indicators for COVID-19 hinders the comparability of data among c
The Tvären structure in southeastern Sweden has been listed as a confirmed marine-target impact structure for decades. However, to date, no measurements and/or indexed data of planar deformation features in quartz grains from the structure have been published or any other unequivocal evidence of impact. Here, we present an investigation aimed at searching for shocked quartz in the 224 m deep Tväre
In 2022, the Intergovernmental Panel on Climate Change (IPCC) established that global greenhouse gas emissions trajectories are not on track to limiting warming to less than 2 ° C above pre-industrial averages (IPCC 2022a). Given that broader progress towards ambitious climate change and sustainability goals remains incremental, a whole-of-society approach, including transformative innovation in t
Acute postoperative pain remains a major clinical challenge, affecting both recovery and resource utilisation. Beyond nociceptive input, pain is shaped by cognitive and emotional factors, including patient expectations. This narrative review examines the role of expectations in perioperative pain modulation, framed within predictive coding and Bayesian inference models. These models conceptualise
The use of X-ray structures to determine and interpret the ferryl iron-oxygen bond order in molecular oxygen-activating heme enzymes has, in the past, been controversial. This has mainly stemmed from the susceptibility of ferryl species to X-ray-induced electronic state changes. In this work we establishe using time-resolved serial femtosecond X-ray crystallography (tr-SFX) on a dye-decolourising
Epoxide hydrolases are essential enzymes that convert epoxides into 1,2-diols, contributing to detoxification, metabolism, and signaling in a wide range of organisms. In this study, we employed hybrid quantum mechanics/molecular mechanics (QM/MM) calculations to investigate the catalytic mechanism of potato epoxide hydrolase 1 (StEH1), specifically focusing on the hydrolysis of trans-stilbene oxid
Quantum refinement (QR) is an approach in which the empirical restraints used in standard structural refinement to ensure that the details of the structure, e.g. bond lengths and angles, make chemical sense are replaced by more accurate quantum mechanical calculations for a small but interesting part of the structure. QR has previously been used for X-ray and neutron crystallography, cryogenic
Herein, we present a case of severe immune-related adverse events (irAEs), myocarditis with myositis, and myasthenia gravis overlap syndrome (IM3OS) in a patient receiving an immune checkpoint inhibitor (ICI), as adjuvant therapy after surgery for muscle-invasive bladder cancer. An 80-year-old woman who had undergone a total cystectomy for bladder cancer presented with ptosis, diplopia, and paraly
Aluminum is a promising carbon-free energy carrier, but advancing its use requires detailed understanding of its combustion behavior at the single-particle level. Measuring the transient surface temperatures of burning aluminum droplets is particularly challenging due to their small size, extreme temperatures, and fast dynamics. In this work, we demonstrate a multispectral pyrometry approach based
