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The intestine contains some of the most diverse and complex immune compartments in the body. Here we describe a method for isolating human gut-associated lymphoid tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolated lymphoid follicles (SM-ILFs and M-ILFs, respectively) as well as in GALT-free intestinal lamina propria (LP). SM-ILF and
Serum thymidine kinase (TK) was determined in a family with congenital dyserythropoietic anaemia type m (CDA, type III). 20 patients and 10 of their healthy siblings were investigated. Elevated TK was found in all 20 patients (median 56.2 U) but their healthy siblings had normal values (median 2.65 U). We suggest that determination of TK should be used for discrimination between healthy siblings a
Results on 105 cases with histopathologically confirmed non-Hodgkin's lymphoma (NHL) and 335 controls from a previously published case-control study on malignant lymphoma are presented together with some extended analyses. No occupation was a risk factor for NHL. Exposure to phenoxyacetic acids yielded, in the univariate analysis, an odds ratio of 5.5 with a 95% confidence interval of 2.7–11. Most
The assessment of causal relationships between exposure and disease usually requires epidemiological studies. Randomized trials on humans are rarely achievable but can sometimes be accomplished in a secondary follow-up of the long-term side effects, e. g., of drugs. The association between smoking and lung cancer is a classical example of important information discovered by epidemiological studies
Over the past few decades, there has been an increase in the number of children receiving home mechanical ventilation (HMV), and in many ways, families have taken responsibility for the required advanced homecare, which has placed considerable time demands on the family unit. Little is known about the life situation of the siblings of HMV-assisted children; their own voices and an insider perspect
Aim: To analyse and synthesise the research that has investigated the experience of home in relation to home mechanical ventilation (HMV). Method: Systematic integrative review. Four electronic databases (CINAHL, PubMed, Scopus and ISI Web of Knowledge) were searched between January 2010 and April 2017 as well as reference lists of included studies. Quantitative and qualitative studies meeting the
By giving a brief overview of the metaconcepts in nursing, with a focus on environment, we sketch a theoretical framework for an emancipatory perspective in nursing care practice. To meet the requirements of equality in care and treatment, we have in our theoretical framework added a critical lifeworld perspective to the antioppressive practice, to meet requirements of equity in health care encoun
Parkinsons sjukdom är den näst vanligaste neurodegenerativa sjukdomen. Lewykroppar med alfa-synuklein som huvudbeståndsdel och förlust av dopaminerga nervceller i substantia nigra är neuropatologiska kännetecken. Diagnosen baseras på förekomst av bradykinesi och rigiditet eller vilotremor. Sjukdomen är också förknippadmed många icke-motoriska symtom. Behandlingen baserar sig främst på farmakologisParkinson's disease is the second most common neurodegenerative disease. Lewy bodies with alpha-synuclein as the major component and loss of dopaminergic nerve cells in substantia nigra are neuropathological features. The diagnosis of Parkinson's disease is based on the occurrence of bradykinesia, rigidity and resting tremor. The disease is also associated with several non-motor symptoms. The ther
To what extent does the visual system process color and form separately? Proponents of the segregation view claim that distinct regions of the cortex are dedicated to each of these two dimensions separately. However, evidence is accumulating that color and form processing may, at least to some extent, be intertwined in the brain. In this perspective, we review psychophysical and neurophysiological
The impairment of multisensory integration in schizophrenia is often explained by deficits of attentional selection. Emotion perception, however, does not always depend on attention because affective stimuli can capture attention automatically. In our study, we specify the role of attention in the multisensory perception of emotional stimuli in schizophrenia. We evaluated attention by interference
In scrutinizing a scene, the eyes alternate between fixations and saccades. During a fixation, two component processes can be distinguished: visual encoding and selection of the next fixation target. We aimed to distinguish the neural correlates of these processes in the electrical brain activity prior to a saccade onset. Participants viewed color photographs of natural scenes, in preparation for
Analyzing single trial brain activity remains a challenging problem in the neurosciences. We gain purchase on this problem by focusing on globally synchronous fields in within-trial evoked brain activity, rather than on localized peaks in the trial-averaged evoked response (ER). We analyzed data from three measurement modalities, each with different spatial resolutions: magnetoencephalogram (MEG),
Adaptation is widely used as a tool for studying selectivity to visual features. In these studies it is usually assumed that the loci of feature selective neural responses and adaptation coincide. We used an adaptation paradigm to investigate the relationship between response and adaptation selectivity in event-related potentials (ERPs). ERPs were evoked by the presentation of colored Glass patter
Perceptual interpretation of the same multisensory stimuli may rely upon influence of attention on multisensory integration. We tested this hypothesis by recording the brain activity using magnetoencephalography in a passing-bouncing illusion with sound. Early activation of the attention-related brain areas and subsequent involvement of the multisensory areas were associated with the bouncing perc
We considered the hypothesis that spontaneous dissociation between the direction of attention and eye movement causes encoding failure in change detection. We tested this hypothesis by analyzing eye fixation-related potentials (EFRP) at the encoding stage of a change blindness task; when participants freely inspect a scene containing an unmarked target region, in which a change will occur in a sub
We investigated the relationship between visual experience and temporal intervals of synchronized brain activity. Using high-density scalp electroencephalography, we examined how synchronized activity depends on visual stimulus information and on individual observer sensitivity. In a perceptual grouping task, we varied the ambiguity of visual stimuli and estimated observer sensitivity to this vari
